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V3: an enigmatic isoform of the proteoglycan versican
American Journal of Physiology - Cell Physiology, 2023V3 is an isoform of the extracellular matrix (ECM) proteoglycan (PG) versican generated through alternative splicing of the versican gene such that the two major exons coding for sequences in the protein core that support chondroitin sulfate (CS) glycosaminoglycan (GAG) chain attachment are excluded. Thus, versican V3 isoform carries no GAGs. A survey
Thomas N Wight +2 more
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A Role for Versican in the Development of Leiomyosarcoma [PDF]
Journal of Biological Chemistry, 2014 Leiomyosarcoma (LMS) is a mesenchymal cancer that occurs throughout the body. Although LMS is easily recognized histopathologically, the cause of the disease remains unknown. Versican, an extracellular matrix proteoglycan, increases in LMS. Microarray analyses of 80 LMSs and 24 leiomyomas showed a significant elevated expression of versican in human ...
Steven L Bressler +2 more
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Versican expression in human cervical cancer
European Journal of Cancer, 2007Versican expression may enhance tumour invasion and metastasis. However, the expressions of versican in cervical cancer have seldom been characterised. The aim of this study was to investigate versican expression in human cervical cancers. We immunohistochemically investigated the expression of versican protein in 174 cervical cancers and analysed the ...
J Kodama, A Hongo, Yuji Hiramatsu
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Versican in Health and Disease
Connective Tissue Research, 2008Versican is a component of the extracellular matrix, which interacts with several matrix and cell surface molecules. Versican plays central roles in tissue morphogenesis and homeostasis and is implicated in the development of numerous diseases. The expression of versican by multiple cell types is differentially regulated in a temporal and spatial ...
Achilleas D Theocharis
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Versican in the Tumor Microenvironment
2020Versican is an extracellular matrix proteoglycan with nonredundant roles in diverse biological and cellular processes, ranging from embryonic development to adult inflammation and cancer. Versican is essential for cardiovascular morphogenesis, neural crest migration, and skeletal development during embryogenesis.
Athanasios, Papadas +1 more
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Defining the versican interactome in lung health and disease
American Journal of Physiology-Cell Physiology, 2022The extracellular matrix (ECM) imparts critical mechanical and biochemical information to cells in the lungs. Proteoglycans are essential constituents of the ECM and play a crucial role in controlling numerous biological processes, including regulating cellular phenotype and function. Versican, a chondroitin sulfate proteoglycan required for embryonic
Fengying Tang +5 more
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Versican in human fetal skin development
Anatomy and Embryology, 1999The extracellular matrix of human fetal skin differs substantially from that of adult skin. Fetal skin contains sparse amounts of fibrillar collagen enmeshed in a highly hydrated amorphous matrix composed of hyaluronan and sulfated proteoglycans. Both fetal and adult skin contain two major interstitial proteoglycans that are extracted by chaotrophic ...
J M, Sorrell +3 more
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T-cell responses to versican in ankylosing spondylitis
Rheumatology International, 2009The objective of our study was to undertake a systematic analysis of the T-cell response to the proteoglycan versican G1-globular domain (VG1) in ankylosing spondylitis (AS) as immunity to VG1 in mice can induce a pathology closely resembling AS. Peripheral blood lymphocytes from 36 AS patients and 33 healthy controls were incubated with recombinant ...
Tae-Jong, Kim +5 more
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Perspectives on developmental neurobiology, 1997
Proteoglycans have long been recognized as participating in a number of biological activities ranging from structural roles to regulation of transcription. Versican is a large chondroitin sulfate proteoglycan expressed in several tissues, including the nervous system.
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Proteoglycans have long been recognized as participating in a number of biological activities ranging from structural roles to regulation of transcription. Versican is a large chondroitin sulfate proteoglycan expressed in several tissues, including the nervous system.
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Versican modulates gap junction intercellular communication
Journal of Cellular Physiology, 2007AbstractVersican is a large chondroitin sulfate proteoglycan and belongs to the family of lecticans. Versican possesses two globular domains, G1 and G3 domain, separated by a CS‐attachment region. The CS‐attachment region present in the middle region is divided into two spliced domains named CSα and β.
Wang, Sheng +4 more
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