Results 61 to 70 of about 945,119 (285)

Essays on the Economics of Retailing: Payments, Finance and Vertical Restraints [PDF]

open access: yes, 2013
Much of the analysis of industrial organization implicitly assumes that firms sell directly to final consumers. However, many firms do not sell directly to the final consumers, but rather use intermediaries, such as wholesalers and retailers to ...
Saxén, Frans
core  

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

open access: yesAdvanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie   +12 more
wiley   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

open access: yesAdvanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi   +7 more
wiley   +1 more source

La danse comme réécriture « géopoétique » de l’espace ?

open access: yesGéographie et Cultures, 2015
It would be from a linear perspective that we decided to address the "dance geography" theme. So it is not so much on the way that geography, as a science, can study dance that interests us.
Céline Torrent
doaj   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

open access: yesAdvanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu   +17 more
wiley   +1 more source

Some empirical regularities on vertical restraints [PDF]

open access: yes, 2006
Vertical restraints most often arise when an upstream firm wants to restrict the choices of a downstream distributor in order to increase profits. The aim of this paper is to analyze some empirical regularities in the motivations for vertical restraints.
González Cerdeira, Xulia
core   +1 more source

Estimating complementarity among vertical restraints: Evidence from manufacturing firms [PDF]

open access: yes
This paper uses a bivariate probit model to analyze firms' decisions to impose regimes of exclusive dealing and/or exclusive territories with their distributors.
Daniel Miles, Xulia González
core  

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li   +9 more
wiley   +1 more source

A Genealogy of Vertical Restraints Doctrine [PDF]

open access: yes, 1989
Traditional antitrust jurisprudence has assumed that competition constitutes the only legitimate policy basis for antitrust doctrine. This Article disputes that assumption, arguing that early antitrust history also reflects strong commitments to ...
Peritz, Rudolph J.
core   +3 more sources

The Anatomy and Length Changes of the Lateral Patellofemoral Ligament and Lateral Patellotibial Ligament

open access: yesOrthopaedic Journal of Sports Medicine, 2020
Objectives: The lateral patellar restraints (lateral patellofemoral ligament [LPFL], lateral patellotibial ligament [LPTL] and lateral patellomeniscal ligament [LPML]) are relatively poorly understood entities, which are important in patellar stability ...
Hailey Huddleston   +6 more
doaj   +1 more source

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