Results 101 to 110 of about 13,176,453 (293)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Peroxisomal Disorders Diagnosis

Pediatric Neurology Briefs, 1998
The clinical manifestations of 27 patients affected with peroxisomal disorders and seen between 1982 and 1997 are described from the Hopital Necker-Enfants Malades, Paris, and other centers.
J Gordon Millichap
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Very-Long-Chain Fatty Acids Are Involved in Polar Auxin Transport and Developmental Patterning in \u3ci\u3eArabidopsis\u3c/i\u3e [PDF]

, 2010
Very-long-chain fatty acids (VLCFAs) are essential for many aspects of plant development and necessary for the synthesis of seed storage triacylglycerols, epicuticular waxes, and sphingolipids. Identification of the acetyl-CoA carboxylase PASTICCINO3 and
Tellier, F., Bellec, Y., Jessica Marion, Napier, Johnathan A., Beaudoin, Frédéric, Molino, D., Roudier, Francois, Halima Morin, Christine Rochat, Richard Haslam, Liên Bach, Faure, J-D., François Roudier, Patrick Moreau, Palauqui, Jean-Christophe, DaCosta, Marco, Louise Michaelson, Marion, Jessica, Tellier, Frédérique, Martine Miquel, Haslam, R. P., Vignard, J., Frédérique Tellier, Markham, J. E., Michaelson, Louise V., Markham, Jennifer E., Faure, Jean Denis, Haslam, Richard, Markham, Jonathan E., Rochat, C., Napier, J. A., Renne, C., Palauqui, J-C., Roudier, F., Jennifer E. Markham, Lima, A., Lionel Gissot, Rochat, Christine, Napier, Jonathan, Michaelson, Louise, V., Lima, Amparo, Jean-Denis Faure, Miquel, Martine, Moreau, P., Johnathan Napier, Gissot, Lionel, Charlotte Renne, Beaudoin, F., Miquel, M., Dacosta, M., Jean-Christophe Palauqui, Morin, Halima, Bach, L., Roudier, Françoise, Renne, Charlotte, Morin, H., Michaelson, L. V., Marion, J., Amparo Lima, Vignard, Julien, Michaelson, Louise, Molino, Diana, Julien Vignard, Bach, Liên, Moreau, Patrick, Yannick Bellec, Bellec, Yannick, Faure, Jean-Denis, Diana Molino, Frédéric Beaudoin, Gissot, L., Marco DaCosta   +71 more
core   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

A randomised controlled trial investigating the effect of n-3 long-chain polyunsaturated fatty acid supplementation on cognitive and retinal function in cognitively healthy older people: the Older People And n-3 Long-chain polyunsaturated fatty acids (OPAL) study protocol [ISRCTN72331636]. [PDF]

, 2006
The number of individuals with age-related cognitive impairment is rising dramatically in the UK and globally. There is considerable interest in the general hypothesis that improving the diet of older people may slow the progression of cognitive decline.
Hardy, Pollyanna, Rosemary Knight, Ann Truesdale, Clemens, Felicity, Hardy Pollyanna, Graham E Holder, Vickers Madge, Fletcher, Astrid E, Felicia A Huppert, Elbourne, Diana, Richards, Marcus, Knight, Rosemary, Fletcher Astrid E, Pollyanna Hardy, Madge Vickers, Vickers, Madge, Letley Louise, Letley, Louise, Dangour, Alan D, Felicity Clemens, Dangour Alan D, Ricardo Uauy, Louise Letley, Knight Rosemary, Diana Elbourne, Fasey, Nicky, Uauy, Ricardo, Uauy Ricardo, Holder, Graham E, Huppert Felicia A, Richards Marcus, Alan D Dangour, Truesdale Ann, Astrid E Fletcher, Marcus Richards, Elbourne Diana, Nicky Fasey, Clemens Felicity, Holder Graham E, Fasey Nicky, Truesdale, Ann, Huppert, Felicia A   +41 more
core   +4 more sources

Reduced chain length in myelin sphingolipids and poorer motor coordination in mice deficient in the fatty acid elongase Elovl1

FASEB BioAdvances, 2019
Very‐long‐chain fatty acids, with a chain length of >C20, are abundant in myelin sphingolipids. Recently, a de novo mutation in the ELOVL1 gene, which encodes fatty acid elongase, was identified in patients with neurocutaneous disorders involving skin ...
Masashi Isokawa, Takayuki Sassa, Satoko Hattori, Tsuyoshi Miyakawa, Akio Kihara   +4 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Very-long-chain fatty acids are required for cell plate formation during cytokinesis in Arabidopsis thaliana

, 2011
Acyl chain length is thought to be crucial for biophysical properties of the membrane, in particular during cell division, when active vesicular fusion is necessary.
Lionel Gissot, Tellier, F., Jessica Marion, Napier, Johnathan A., Jean-Denis Faure, Johnathan A. Napier, Moreau, P., Liên Bach, Gissot, Lionel, Faure, J-D., Béatrice Satiat-Jeunemaître, Patrick Moreau, Satiat-Jeunemaitre, B., Jean-Christophe Palauqui, Bach, L., Palauqui, Jean-Christophe, Marion, Jessica, Tellier, Frédérique, Marion, J., Frédérique Tellier, Satiat-Jeunemaître, Béatrice, Bach, Liên, Moreau, Patrick, Faure, Jean-Denis, Napier, J. A., Gissot, L., Palauqui, J-C.   +26 more
core   +1 more source

Stearate-derived very long-chain fatty acids are indispensable to tumor growth. [PDF]

EMBO J, 2023
Chu Q, Liu P, Song Y, Yang R, An J, Zhai X, Niu J, Yang C, Li B.   +8 more
europepmc   +2 more sources