Enhancing very long chain fatty acids production in Yarrowia lipolytica [PDF]
Microbial Cell Factories, 2022 Background Very long chain fatty acids (VLCFA) and their derivatives are industrially attractive compounds. The most important are behenic acid (C22:0) and erucic acid (C22:1Δ13), which are used as lubricants, and moisturizers.
Peter Gajdoš +3 more
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Very long-chain fatty acids drive 1-deoxySphingolipid toxicity [PDF]
Nature Communications1-Deoxysphingolipids (1-deoxySLs) are atypical sphingolipids formed when serine palmitoyltransferase incorporates L-alanine instead of L-serine. Elevated 1-deoxySLs are associated with hereditary sensory neuropathy type 1 and diabetic neuropathy, but the
Adam Majcher +13 more
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Novel Cellular Functions of Very Long Chain-Fatty Acids: Insight From ELOVL4 Mutations [PDF]
Frontiers in Cellular Neuroscience, 2019 Elongation of Very Long chain fatty acids-4 (ELOVL4) protein is a member of the ELOVL family of fatty acid elongases that is collectively responsible for catalyzing formation of long chain fatty acids.
Ferenc Deák +11 more
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Saturated very long-chain fatty acids regulate macrophage plasticity and invasiveness [PDF]
Journal of Neuroinflammation, 2022 Saturated very long-chain fatty acids (VLCFA, ≥ C22), enriched in brain myelin and innate immune cells, accumulate in X-linked adrenoleukodystrophy (X-ALD) due to inherited dysfunction of the peroxisomal VLCFA transporter ABCD1.
Bettina Zierfuss +15 more
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Genotoxicity evaluation of a fish oil concentrate containing Very Long Chain Fatty Acids [PDF]
Toxicology Reports, 2023 Very long chain fatty acids (VLCFAs) are lipids found in fish with a chain length longer than C22. They represent a minor lipid fraction composing of less than 1% of the total lipid.
Derek Tobin +3 more
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Algae: Critical Sources of Very Long-Chain Polyunsaturated Fatty Acids [PDF]
Biomolecules, 2019 Polyunsaturated fatty acids (PUFAs), which are divided into n-3 and n-6 classes, are essential for good health in humans and many animals. They are metabolised to lipid mediators, such as eicosanoids, resolvins and protectins.
John L. Harwood
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Reassessing very long chain fatty acids elevations: Sitosterolemia as a non-peroxisomal cause [PDF]
Molecular Genetics and Metabolism ReportsVery-long-chain fatty acids (VLCFAs) are commonly used to diagnose peroxisomal disorders, but elevated levels may also result from other non-peroxisomal causes, leading to diagnostic challenges.
Merve Yoldaş Çelik +3 more
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Practical preparation of unsaturated very-long-chain fatty acids (VLCFAs) and very-long-chain alkene pollinator attractants [PDF]
Scientific ReportsTo prepare very-long-chain fatty acids and alkenes (VLCFAs and VLC alkenes) that are known pollinator attractants for sexually deceptive orchids, and biosynthetic precursors thereof, we applied a methodology allowing us to prepare monounsaturated VLCFAs ...
Björn Bohman +3 more
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Very Long Chain Fatty Acids Are Functionally Involved in Necroptosis [PDF]
Cell Chemical Biology, 2017 Necroptosis is a form of regulated cell death that is linked to various human diseases. Distinct membrane-related, thus lipid-dependent, alterations take place during necroptosis. However, little is known about the roles of specific lipids in this process. We used an untargeted LC-MS-based approach to reveal that distinct lipid species are regulated at
Laura R Parisi +2 more
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Very long-chain fatty acids accumulate in breast cancer tissue and serum [PDF]
Cancer Cell InternationalBackground Breast cancer (BC) remains one of the most common cancers with relatively high mortality and is associated with alterations in fatty acid (FA) metabolism.
Alicja Pakiet +10 more
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