Results 21 to 30 of about 142,528 (291)

Peroxisomes attenuate cytotoxicity of very long-chain fatty acids

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2023
One of the major functions of peroxisomes in mammals is oxidation of very long-chain fatty acids (VLCFAs). Genetic defects in peroxisomal β-oxidation result in the accumulation of VLCFAs and lead to a variety of health problems, such as demyelination of nervous tissues.
Ali, Hanif, Kobayashi, Miyu, Morito, Katsuya, Hasi, Rumana Yesmin, Aihara, Mutsumi, Hayashi, Junji, Kawakami, Ryushi, Tsuchiya, Koichiro, Sango, Kazunori, Tanaka, Tamotsu   +9 more
openaire   +2 more sources

ELOVL4: Very long-chain fatty acids serve an eclectic role in mammalian health and function. [PDF]

Prog Retin Eye Res, 2019
Hopiavuori BR, Anderson RE, Agbaga MP.
europepmc   +2 more sources

Metabolism of Very Long-Chain Fatty Acids: Genes and Pathophysiology [PDF]

Biomolecules & Therapeutics, 2014
Fatty acids (FAs) are highly diverse in terms of carbon (C) chain-length and number of double bonds. FAs with C>20 are called very long-chain fatty acids (VLCFAs). VLCFAs are found not only as constituents of cellular lipids such as sphingolipids and glycerophospholipids but also as precursors of lipid mediators.
Sassa, Takayuki, Kihara, Akio
openaire   +2 more sources

Placental transfer of long-chain polyunsaturated fatty acids (LC-PUFA) [PDF]

, 2007
Considerable evidence exists for marked beneficial effects of omega-3 long-chain polyunsaturated fatty acids (LC-PUFA) during pregnancy. The omega-3 LCPUFA docosahexaenoic acid (DHA) is incorporated in large amounts in fetal brain and other tissues ...
Hans Demmelmair, Elvira Larqué, Berthold Koletzko, Koletzko, Berthold, Larqué, Elvira, Demmelmair, Hans   +5 more
core   +1 more source

Inverse Association between trans Isomeric and Long-Chain Polyunsaturated Fatty Acids in Pregnant Women and Their Newborns: Data from Three European Countries [PDF]

, 2011
Background: trans unsaturated fatty acids are thought to interfere with essential fatty acid metabolism. To extend our knowledge of this phenomenon, we investigated the relationship between trans isomeric and long-chain polyunsaturated fatty acids ...
Krauss-Etschmann, S., É. Szabó, Marosvolgyi, Tamas, Campoy, C., T. Marosvölgyi, Decsi, Tamás, Marosvölgyi, T., C. Campoy, B. Koletzko, M. Escolano, Campoy, Cristina, Cruz, M., Szabó, É., Krauss-Etschmann, Susanne, S. Krauss-Etschmann, M. Cruz, Szabo, Eva, Escolano, M., Marchal, G., T. Decsi, Koletzko, Berthold, H. Demmelmair, Demmelmair, Hans, G. Marchal   +23 more
core   +1 more source

The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations. [PDF]

, 2008
This paper reviews current knowledge on the role of the long-chain polyunsaturated fatty acids (LC-PUFA), docosahexaenoic acid (DHA, C22:6n-3) and arachidonic acid (AA, 20:4n-6), in maternal and term infant nutrition as well as infant development ...
Alexandre Lapillonne, Tamas Decsi, S. Forsyth, Niels J Secher, Berthold Koletzko, Willatts, Peter, MD Berthold Koletzko, C. Agostoni, Hansjosef Bö Hles, N. J. Secher, NN, NN, Szajewska, Hania, Lapillonne, Alexandre, Irene Cetin, Carlo Agostoni, Ricardo Uauy, Putet, Guy, Eric Lien, Forsyth, Stewart, I. Hoesli, Uauy, Ricardo, Mike Symonds, Dudenhausen, Joachim W, Uauy Dagach-Imbarack, Ricardo, Cristina Campoy, W. Holzgreve, Stewart Forsyth, Hania Szajewska, T. Decsi, Irene Hoesli, Koletzko, Berthold, Lien, Eric, J. W. Dudenhausen, Peter Willatts, Secher, Niels J, C. Campoy, Guy Putet, B. Koletzko, H. Szajewska, E. Lien, G. Putet, Joachim W Dudenhausen, Dudenhausen, Joachim W., Boehles, Hansjosef, Hoesli, Irene, Böhles, Hansjosef, Decsi, Tamas, Dupont, Cristophe, Cristophe Dupont, M. Symonds, Campoy, Cristina, Secher, Niels J., Symonds, Mike, P. Willatts, Cetin, Irene, A. Lapillonne, I. Cetin, Agostoni, Carlo, H. Böhles, Wolfgang Holzgreve, Holzgreve, Wolfgang, R. Uauy, World Association of Perinatal Medicine Dietary Guidelines Worki, C. Dupont   +63 more
core   +1 more source

Peroxisomal beta-oxidation of branched chain fatty acids in human skin fibroblasts.

Journal of Lipid Research, 1992
Human skin fibroblasts in suspension are able to degrade [1-14C]-labeled alpha- and gamma-methyl branched chain fatty acids such as pristanic and homophytanic acid.
H Singh, M Brogan, D Johnson, A Poulos
doaj   +1 more source

Fatty acids and lipid mediators in inflammatory bowel disease: from mechanism to treatment

Frontiers in Immunology, 2023
Inflammatory Bowel Disease (IBD) is a chronic, relapsing inflammatory disorder of the gastrointestinal tract. Though the pathogenesis of IBD remains unclear, diet is increasingly recognized as a pivotal factor influencing its onset and progression. Fatty
Dong Yan, Shuyu Ye, Shuyu Ye, Yue He, Sidan Wang, Sidan Wang, Yi Xiao, Yi Xiao, Xin Xiang, Minzi Deng, Minzi Deng, Weiwei Luo, Weiwei Luo, Xuejie Chen, Xuejie Chen, Xiaoyan Wang, Xiaoyan Wang   +16 more
doaj   +1 more source

Omega 3 fatty acids on child growth, visual acuity and neurodevelopment. [PDF]

, 2012
The aim of this review is to evaluate the effects of omega-3 long chain polyunsaturated fatty acids (n-3 LCPUFA) supplementation in pregnant and lactating women and infants during postnatal life, on the visual acuity, psychomotor development, mental ...
Anjos, Tania, Gomes Anjos, Tania, Szajewska, Hania, Uauy, Ricardo, Campoy Folgoso, Cristina, Escolano Margarit, María Victoria, Uauy Dagach, Ricardo, Campoy, Cristina, Escolano-Margarit, Ma Victoria   +8 more
core   +1 more source

Epidermal expression of an Elovl4 transgene rescues neonatal lethality of homozygous Stargardt disease-3 mice

Journal of Lipid Research, 2011
Elongase of very long chain fatty acids-4 (ELOVL4) is the only mammalian enzyme known to synthesize C28-C36 fatty acids. In humans, ELOVL4 mutations cause Stargardt disease-3 (STGD3), a juvenile dominant macular degeneration. Heterozygous Stgd3 mice that
Anne McMahon, Igor A. Butovich, Wojciech Kedzierski   +2 more
doaj   +1 more source