Results 31 to 40 of about 142,528 (291)

The Very-Long-Chain Fatty Acid Synthase Is Inhibited by Chloroacetamides

Zeitschrift für Naturforschung C, 2004
Abstract The first elongation step to form very-long-chain fatty acids (VLCFAs) is catalyzed by the VLCFA-synthase. CoA-activated fatty acids react with malonyl-CoA to condense a C2-unit. As shown with recombinant enzyme this reaction is specifically inhibited by chloroacetamide herbicides. The inhibition is alleviated when the inhibitor
Thomas, Götz, Peter, Böger
openaire   +2 more sources

FADS Gene Cluster Polymorphisms: Important Modulators of Fatty Acid Levels and Their Impact on Atopic Diseases [PDF]

, 2009
Long-chain polyunsaturated fatty acids (LC-PUFAs) play an important role in several physiological processes and their concentration in phospholipids has been associated with several complex diseases, such as atopic disease.
Lattka, E., Lattka, Eva, Heinrich, Joachim, Illig, T., Koletzko, Berthold, Heinrich, J., Illig, Thomas, Koletzko, B.   +7 more
core   +1 more source

Distribution of molecular species of sphingomyelins in different parts of bovine digestive tract

Journal of Lipid Research, 1975
Sphingomyelins were isolated from mucosal layers of bovine rennet stomach, duodenum, jejunoileum, and colon ascendens. The ceramides obtained after phospholipase degradation were characterized by thin-layer chromatography, mass spectrometry, and gas ...
M.E. Breimer
doaj   +1 more source

Role of long-chain and very-long-chain polyunsaturated fatty acids in macular degenerations and dystrophies [PDF]

Clinical Lipidology, 2011
Macular degeneration is a progressive, bilateral eye disorder that damages the macula of the human eye. The most common form of macular degeneration is age-related macular degeneration (AMD), which is the leading cause of irreversible blindness in people older than 50 years in developed countries.
Aihua, Liu, Yanhua, Lin, Ryan, Terry, Kelly, Nelson, Paul S, Bernstein   +4 more
openaire   +2 more sources

A new family of very long chain alpha,omega-dicarboxylic acids is a major structural fatty acyl component of the membrane lipids of Thermoanaerobacter ethanolicus 39E.

Journal of Lipid Research, 1994
A new family of alpha,omega-dicarboxylic, very long chain fatty acids was isolated and characterized from the lipids of thermophilic anaerobic eubacterium, Thermoanaerobacter ethanolicus 39E. After the isolation of the membrane, the fatty acyl components
S Jung, J G Zeikus, R I Hollingsworth
doaj   +1 more source

Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency: Family Impact and Perspectives

International Journal of Neonatal Screening, 2023
Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCADD) is a fatty acid oxidation disorder characterized by the decreased ability of the enzyme very-long-chain acyl-CoA dehydrogenase to break down fatty acids with 14 to 20-long carbon chains.
Sarah Crawford, Elizabeth Sablon, Nadia Ali, Ami R. Rosen, Patricia L. Hall, Juanita Neira Fresneda   +5 more
doaj   +1 more source

Production of very long chain polyunsaturated omega-3 and omega-6 fatty acids in plants [PDF]

, 2004
We report the production of two very long chain polyunsaturated fatty acids, arachidonic acid (AA) and eicosapentaenoic acid (EPA), in substantial quantities in a higher plant.
Olga Sayanova, Sayanova, O. V., Mugford, S., Colin M Lazarus, Qi, B., Dobson, G., Lazarus, C. M., Lazarus, CM, Johnathan A Napier, Napier, JA, Stobart, A. K., Mugford, S, Fraser, T., Butler, JL, Gary Dobson, A Keith Stobart, Butler, J., Stobart, AK, Dobson, G, Baoxiu Qi, Tom Fraser, Qi, B, Fraser, TCM, Napier, J. A., Sayanova, OV, Sam Mugford, Justine Butler   +26 more
core   +1 more source

Biosynthetic mechanism of very long chain polyunsaturated fatty acids in Thraustochytrium sp. 26185[S]

Journal of Lipid Research, 2016
Thraustochytrium, a unicellular marine protist, has been used as a commercial source of very long chain PUFAs (VLCPUFAs) such as DHA (22:6n-3). Our recent work indicates coexistence of a Δ4-desaturation-dependent pathway (aerobic) and a polyketide ...
Dauenpen Meesapyodsuk, Xiao Qiu
doaj   +1 more source

Very long-chain saturated fatty acids and diabetes and cardiovascular disease

Current Opinion in Lipidology, 2021
Purpose of review In contrast to other saturated fatty acids, very long-chain saturated fatty acids (VLSFAs) have received limited attention The purpose of this review is to summarize the associations of VLSFAs, including arachidic acid, behenic acid, and lignoceric acid, with cardiovascular disease outcomes and type 2 diabetes;
Lemaitre, Rozenn N., King, Irena B.
openaire   +3 more sources

Biochemical characterization of the very long-chain fatty acid elongase ELOVL7 [PDF]

FEBS Letters, 2011
Very long-chain fatty acids (VLCFAs) have a variety of physiological functions and are related to numerous disorders. The key step of VLCFA elongation is catalyzed by members of the elongase family, ELOVLs. Mammals have seven ELOVLs (ELOVL1-7), yet none of them has been purified and analyzed.
Naganuma, Tatsuro, Sato, Yuichiro, Sassa, Takayuki, Ohno, Yusuke, Kihara, Akio   +4 more
openaire   +3 more sources