Results 51 to 60 of about 142,528 (291)

Role of MRI in X-linked adrenoleukodystrophy—A case report

Radiology Case Reports, 2022
X-linked adrenoleukodystrophy is a rare inherited peroxisomal disorder that occurs due to a genetic mutation. This mutation impairs normal transport of very long-chain fatty acids (VLCFAs) into peroxisomes, hence impeding VLCFA breakdown leading to its ...
Sajiva Aryal, MBBS, Suraj Sharma, MBBS, MD, Saroj Poudel, MBBS, Sunita Sharma, MPH   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Impact of fatty acid status on immune function of children in low-income countries.

, 2011
In vitro and animal studies point to numerous mechanisms by which fatty acids, especially long-chain polyunsaturated fatty acids (LCPUFA), can modulate the innate and adaptive arms of the immune system.
Liandré van der Merwe, van der Merwe, Liandré, Prentice, Andrew M, Andrew M. Prentice   +3 more
core   +1 more source

Biosynthesis of food constituents: Lipids. 1. Fatty acids and derivated compounds - a review

Czech Journal of Food Sciences, 2006
This review article gives a survey of the principal biosynthetic pathways that lead to the most important common fatty acids and their derivatives occurring in foods and feeds.
Jan Velíšek, Karel Cejpek
doaj   +1 more source

A novel ABCD1 G1202A mutation in a Chinese patient with pure adrenomyeloneuropathy and literature review

Genes and Diseases, 2021
Adrenomyeloneuropathy (AMN) is a kind of varied disease caused by ABCD1 gene mutation and characterized by very-long-chain fatty acids (VLCFA) accumulation. It is diagnosed by clinical features, high VLCFAs levels and ABCD1 gene mutation.
Yu Zhang, Guoyong Zhang, Wenhui Chen, Zheng Pu, Lu Song, Xinghua Tang, Zhenguo Liu   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Changes in the Serum Fatty Acid Profile After Anhepatic Phase of Orthotopic Liver Transplantation Procedure

Frontiers in Physiology, 2022
During orthotopic liver transplantation (OLT), the patients’ body remains deprived of this organ for some time, which could cause critical changes in the levels of various metabolites in the circulation, including fatty acids. Thus, the aim of this study
Aleksandra Hliwa, Adriana Mika, Maciej Sledzinski, Dariusz Laski, Bruno Ramos-Molina, Tomasz Sledzinski   +5 more
doaj   +1 more source

Biosynthesis of very long chain fatty acids by the sciatic nerve of the rabbit [PDF]

FEBS Letters, 1978
The alkanes, a new class of neurolipids, are accumulated in the brain myelin when compared to the other brain subfractions [l--4]. The role of these hydrophobic substances in the myelin formation is far from clear. It appears that alkanes are required for a correct myelination, since the remaining myelin of the Quaking mutant, which bears a defect of ...
Cassagne, Claude, Darriet, Danielle, Bourre, J.M.   +2 more
openaire   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

A randomised controlled trial investigating the effect of n-3 long-chain polyunsaturated fatty acid supplementation on cognitive and retinal function in cognitively healthy older people: the Older People And n-3 Long-chain polyunsaturated fatty acids (OPAL) study protocol [ISRCTN72331636]. [PDF]

, 2006
The number of individuals with age-related cognitive impairment is rising dramatically in the UK and globally. There is considerable interest in the general hypothesis that improving the diet of older people may slow the progression of cognitive decline.
Hardy, Pollyanna, Rosemary Knight, Ann Truesdale, Clemens, Felicity, Hardy Pollyanna, Graham E Holder, Vickers Madge, Fletcher, Astrid E, Felicia A Huppert, Elbourne, Diana, Richards, Marcus, Knight, Rosemary, Fletcher Astrid E, Pollyanna Hardy, Madge Vickers, Vickers, Madge, Letley Louise, Letley, Louise, Dangour, Alan D, Felicity Clemens, Dangour Alan D, Ricardo Uauy, Louise Letley, Knight Rosemary, Diana Elbourne, Fasey, Nicky, Uauy, Ricardo, Uauy Ricardo, Holder, Graham E, Huppert Felicia A, Richards Marcus, Alan D Dangour, Truesdale Ann, Astrid E Fletcher, Marcus Richards, Elbourne Diana, Nicky Fasey, Clemens Felicity, Holder Graham E, Fasey Nicky, Truesdale, Ann, Huppert, Felicia A   +41 more
core   +1 more source