Results 61 to 70 of about 13,176,453 (293)

Production of very long chain polyunsaturated omega-3 and omega-6 fatty acids in plants [PDF]

, 2004
We report the production of two very long chain polyunsaturated fatty acids, arachidonic acid (AA) and eicosapentaenoic acid (EPA), in substantial quantities in a higher plant.
Olga Sayanova, Sayanova, O. V., Mugford, S., Colin M Lazarus, Qi, B., Dobson, G., Lazarus, C. M., Lazarus, CM, Johnathan A Napier, Napier, JA, Stobart, A. K., Mugford, S, Fraser, T., Butler, JL, Gary Dobson, A Keith Stobart, Butler, J., Stobart, AK, Dobson, G, Baoxiu Qi, Tom Fraser, Qi, B, Fraser, TCM, Napier, J. A., Sayanova, OV, Sam Mugford, Justine Butler   +26 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Capillary gas-liquid chromatographic-mass spectrometric measurement of very long chain (C22 to C26) fatty acids in microliter samples of plasma.

Journal of Lipid Research, 1985
In order to quantify accurately the plasma content of very long chain fatty acids, we have developed a selected ion monitoring gas-liquid chromatographic-mass spectrometric micromethod which allows all of these acids (22:0, 24:1, 24:0, 26:1, and 26:0) to
P Aubourg, P F Bougnères, F Rocchiccioli   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Excess portal venous long-chain fatty acids induce syndrome X via HPA axis and sympathetic activation [PDF]

, 2000
We tested the hypothesis that excessive portal venous supply of long-chain fatty acids to the liver contributes to the development of insulin resistance via activation of the hypothalamus-pituitary-adrenal axis (HPA axis) and sympathetic system.
Scheurink, AJW, Strubbe, JH, Keizer, Klaasjan,, Kuipers, Folkert,, Kuipers, F, Scheurink, Anton J.W.,, Benthem, L, Kuipers, F; id_orcid, Keizer, Klaas-Jan, Wiegman, Coen H.,, Strubbe, Jan H.,, Boer, Sietse F. de,, Steffens, Anton B.,, Steffens, AB, De Boer, SF, Benthem, Lambertus,, Wiegman, CH   +16 more
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Protein Acylation by Saturated Very Long Chain Fatty Acids and Endocytosis Are Involved in Necroptosis [PDF]

, 2020
Necroptosis is a form of regulated cell death that is characterized by membrane permeabilization. This permeabilization is responsible for the inflammatory properties of necroptosis and is critical for disease states involving this process. We previously
Daniel, Lu, Jason G., Kay, Ekin, Atilla-Gokcumen, Laura, Parisi, Apoorva, Pradhan, Kiana, Bynum, Jun, Qu, Sherry, Chemler, Viviana, Monje-Galvan, Ilyas, Berhane, Samuel L., Galster, Omer, Gokcumen, Shichen, Shen   +12 more
core   +1 more source

Esterification of fatty acids at room temperature by chloroform-methanolic HCl–cupric acetate

Journal of Lipid Research, 1973
A new procedure for the preparation of methyl esters from free fatty acids under mild conditions was investigated. Free fatty acids are dissolved in a mixture of chloroform–methanolic HCl–cupric acetate and kept at room temperature for 30 min for ...
Motonori Hoshi, Marcia Williams, Yasuo Kishimoto   +2 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source