Membrane Disruption by Very Long Chain Fatty Acids during Necroptosis. [PDF]
ACS Chem Biol, 2019 Necroptosis is a form of regulated cell death which results in loss of plasma membrane integrity, release of intracellular contents, and an associated inflammatory response. We previously found that saturated very long chain fatty acids (VLCFAs), which contain ≥20 carbons, accumulate during necroptosis.
Parisi LR +8 more
europepmc +6 more sources
Novel Cellular Functions of Very Long Chain-Fatty Acids: Insight From ELOVL4 Mutations [PDF]
Frontiers in Cellular Neuroscience, 2019 Elongation of Very Long chain fatty acids-4 (ELOVL4) protein is a member of the ELOVL family of fatty acid elongases that is collectively responsible for catalyzing formation of long chain fatty acids.
Ferenc Deák +11 more
doaj +2 more sources
Biosynthesis and Functions of Very-Long-Chain Fatty Acids in the Responses of Plants to Abiotic and Biotic Stresses. [PDF]
Cells, 2021 Batsale M +5 more
europepmc +2 more sources
Emerging insights into the function of very long chain fatty acids at cerebellar synapses [PDF]
Neural Regeneration ResearchMartin-Paul Agbaga, Mohiuddin Ahmad
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Very Long-Chain Fatty Acids in Yeast [PDF]
Journal of Bacteriology, 1973 Novel fatty acids ranging from 20 to 30 carbons have been found in Saccharomyces cerevisiae . These comprise 1 to 2% of the total fatty acid fraction.
J W, Welch, A L, Burlingame
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Omega 3: Should we indicate it in our patients?
Revista de la Sociedad Argentina de Diabetes, 2022 Lipids are identified as a fundamental component of the diet because they perform very important functions. They influence the modulation of immune functions and inflammatory processes; attributable to long-chain polyunsaturated fatty acids (long chain ...
Marta Milikowski
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Emerging roles of polyunsaturated fatty acid synthesis pathway in colorectal cancer
Animal Cells and Systems, 2023 The development of colorectal cancer typically involves the accumulated influences of genetic alterations, medical issues, lifestyle, and diet. Dietary fatty acids appear to affect the tumorigenesis and progression of colorectal cancer.
Young-Ah Moon
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The Overlooked Transformation Mechanisms of VLCFAs: Peroxisomal β-Oxidation
Agriculture, 2022 Beta-oxidation(β-oxidation) is an important metabolic process involving multiple steps by which fatty acid molecules are broken down to produce energy.
Qinyue Lu +4 more
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Peroxisomes attenuate cytotoxicity of very long-chain fatty acids
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2023 One of the major functions of peroxisomes in mammals is oxidation of very long-chain fatty acids (VLCFAs). Genetic defects in peroxisomal β-oxidation result in the accumulation of VLCFAs and lead to a variety of health problems, such as demyelination of nervous tissues.
Ali, Hanif +9 more
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Metabolism of Very Long-Chain Fatty Acids: Genes and Pathophysiology [PDF]
Biomolecules & Therapeutics, 2014 Fatty acids (FAs) are highly diverse in terms of carbon (C) chain-length and number of double bonds. FAs with C>20 are called very long-chain fatty acids (VLCFAs). VLCFAs are found not only as constituents of cellular lipids such as sphingolipids and glycerophospholipids but also as precursors of lipid mediators.
Sassa, Takayuki, Kihara, Akio
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