Results 171 to 180 of about 13,176,453 (293)

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

Elongation of very long chain fatty acids-3 (<i>Elovl3</i>) is activated by ZHX2 and is a regulator of cell cycle progression.

Am J Physiol Gastrointest Liver Physiol, 2023
Creasy KT, Ren H, Jiang J, Peterson ML, Spear BT.   +4 more
europepmc   +1 more source

Very long-chain fatty acids are accumulated in triacylglycerol and nonesterified forms in colorectal cancer tissues. [PDF]

Sci Rep, 2021
Hama K, Fujiwara Y, Hayama T, Ozawa T, Nozawa K, Matsuda K, Hashiguchi Y, Yokoyama K.   +7 more
europepmc   +1 more source

Optic nerve demyelination as the presenting feature of adrenoleukodystrophy in a child

Indian Journal of Ophthalmology, 2022
Nirupama Kasturi, Sandip Sarkar, Tanmay Gokhale, Chinnaiah G Delhikumar, Midhusha R Vendoti   +4 more
doaj   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Drug discovery for X-linked adrenoleukodystrophy: An unbiased screen for compounds that lower very long-chain fatty acids. [PDF]

J Cell Biochem, 2021
Moser AB, Liu Y, Shi X, Schrifl U, Hiebler S, Fatemi A, Braverman NE, Steinberg SJ, Watkins PA.   +8 more
europepmc   +1 more source

Microenvironment‐Responsive Nanomedicine Enables Vertical Modulation of Mitochondrial Pathological Networks in Myocardial Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang, Jia Zhou, Wenqin Yuan, Tianjiao Zhao, Yunying Huang, Yingci Xia, Yuting Lin, Fei Li, Qiong Huang, Chong Liu, Kelong Ai, Qun Qin   +11 more
wiley   +1 more source

Propionyl CoA production from odd-chain fatty acids

, 1997
Beta-oxidation of fatty acids with an odd number of carbons inthe chain yields the three-carbon propionyl CoA as the final ...

core  

Plasma Very-Long-Chain Fatty Acids in X-Linked Adrenoleukodystrophy: Diagnostic Insights From a Clinical Laboratory Cohort. [PDF]

J Clin Lab Anal
Blas SM, Pujalte SP, Álvarez AM, Ríos AIÁ, Cabello BM, Moreno CN, Gila ALG, Fuentes ED, Moreno EV, Pecellín CD.   +9 more
europepmc   +1 more source

Function and transcriptional regulation of <i>CsKCS20</i> in the elongation of very-long-chain fatty acids and wax biosynthesis in <i>Citrus sinensis</i> flavedo. [PDF]

Hortic Res, 2022
Wang Y, Yang X, Chen Z, Zhang J, Si K, Xu R, He Y, Zhu F, Cheng Y.   +8 more
europepmc   +1 more source