Results 1 to 10 of about 598,827 (95)
The metabolic conversion of very-low-density lipoprotein into low-density lipoprotein by the extrahepatic tissues of the rat [PDF]
Biochemical Journal, 1979 1. The work reported was designed to provide quantitative information about the capacity of the extrahepatic tissues of the rat to degrade injected VLD lipoproteins (very-low-density lipoproteins, d less than 1.006) to LD lipoproteins (low-density lipoproteins, d 1.006–1.063) and to study the fate of the different VLD-lipoprotein apoproteins during the
M E Targ, B S Suri, Donald S. Robinson
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Synthesis and properties of the very-low-density-lipoprotein receptor and a comparison with the low-density-lipoprotein receptor [PDF]
Biochemical Journal, 1997 The properties of the very-low-density lipoprotein (VLDL) receptor have been studied in Chinese hamster ovary (CHO) cells stably transfected with human VLDL-receptor cDNA and compared with those of the low-density lipoprotein (LDL) receptor expressed under the same conditions. Immunoblotting showed that the cells produced a mature VLDL receptor protein,
Brian L. Knight +3 more
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HDL and plaque regression in a multiphase model of early atherosclerosis [PDF]
, 2023 Atherosclerotic plaques are accumulations of cholesterol-engorged macrophages in the artery wall. Plaque growth is initiated and sustained by the deposition of low density lipoproteins (LDL) in the artery wall. High density lipoproteins (HDL) counterbalance the effects of LDL by accepting cholesterol from macrophages and removing it from the plaque. In
arxiv +1 more source
Is hypertriglyceridemic very low density lipoprotein a precursor of normal low density lipoprotein?
Journal of Lipid Research, 1985 The precursor-product relationship of very low density (VLDL) and low density lipoproteins (LDL) was studied. VLDL obtained from normal (NTG) and hypertriglyceridemic (HTG) subjects was fractionated by zonal ultracentrifugation and subjected to in vitro lipolysis. The individual subfractions and their isolated lipolysis products, as well as IDL and LDL,
Shlomo Eisenberg +3 more
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PPARδ is a very low-density lipoprotein sensor in macrophages [PDF]
Proceedings of the National Academy of Sciences, 2003 Although triglyceride-rich particles, such as very low-density lipoprotein (VLDL), contribute significantly to human atherogenesis, the molecular basis for lipoprotein-driven pathogenicity is poorly understood. We demonstrate that in macrophages, VLDL functions as a transcriptional regulator via the activation of the nuclear receptor peroxisome ...
Chawla, A +8 more
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High expression of antioxidant proteins in dendritic cells: possible implications in atherosclerosis [PDF]
Mol Cell Proteomics 5 (04/2006) 726-36, 2006 Dendritic cells (DCs) display the unique ability to activate naive T cells and to initiate primary T cell responses revealed in DC-T cell alloreactions. DCs frequently operate under stress conditions. Oxidative stress enhances the production of inflammatory cytokines by DCs.
arxiv +1 more source
A comparative study of the lipid panel levels at different duration time and temperature storage [PDF]
arXiv, 2023 Background: the stability of serum specimen during time storage is importance in clinical and medical science researches in addition of diagnosis. Lipids are organic molecules that classified into 8 classes: fatty acids, phospholipids, glycerolipids, saccharolipids, polyketides, prenol lipids, sterol, and sphingolipids.
arxiv
Journal of Lipid Research, 1988 Interactions of high density lipoproteins (HDL) with very low (VLDL) and low (LDL) density lipoproteins were investigated during in vitro lipolysis in the presence of limited free fatty acid acceptor. Previous studies had shown that lipid products accumulating on lipoproteins under these conditions promote the formation of physical complexes between ...
R M Krauss +2 more
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A Weighted U Statistic for Genetic Association Analyses of Sequencing Data [PDF]
Genet Epidemiol. 2014 Dec;38(8):699-708, 2015 With advancements in next generation sequencing technology, a massive amount of sequencing data are generated, offering a great opportunity to comprehensively investigate the role of rare variants in the genetic etiology of complex diseases. Nevertheless, this poses a great challenge for the statistical analysis of high-dimensional sequencing data. The
arxiv +1 more source
Causal Models with Constraints [PDF]
arXiv, 2023 Causal models have proven extremely useful in offering formal representations of causal relationships between a set of variables. Yet in many situations, there are non-causal relationships among variables. For example, we may want variables $LDL$, $HDL$, and $TOT$ that represent the level of low-density lipoprotein cholesterol, the level of lipoprotein
arxiv