Results 71 to 80 of about 679,023 (353)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Microglial large extracellular vesicles propagate early synaptic dysfunction in Alzheimer’s disease [PDF]

, 2022
Martina Gabrielli, Ilaria Prada, Pooja Joshi, Chiara Falcicchia, Giulia D’Arrigo, Grazia Rutigliano, Elisabetta Battocchio, Rossella Zenatelli, Francesca Tozzi, Annalisa Radeghieri, Ottavio Arancio, Nicola Origlia, Claudia Verderio   +12 more
openalex   +1 more source

Reaction-Diffusion System in a Vesicle with Semi-Permeable Membrane

, 2006
We study the Schloegl model in a vesicle with semi-permeable membrane. The diffusion constant takes a smaller value in the membrane region, which prevents the outflow of self-catalytic product.
Blanchedeau P., Carpio A., Dyson F. J., Gray P., Kulka A., Lee K.-J., Mittkov I., Nicolis G., Nishiura Y., Noireaux V., Oparin A. I., Ouyang Q., Pearson J., Schlögl F., Vanag V. K., Winfree A. T., Winston D.   +16 more
core   +1 more source

Fluid Vesicles in Flow [PDF]

, 2014
We review the dynamical behavior of giant fluid vesicles in various types of external hydrodynamic flow. The interplay between stresses arising from membrane elasticity, hydrodynamic flows, and the ever present thermal fluctuations leads to a rich ...
Abreu, David, Levant, Michael, Seifert, Udo, Steinberg, Victor   +3 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Hard Spheres in Vesicles: Curvature-Induced Forces and Particle-Induced Curvature [PDF]

, 1997
We explore the interplay of membrane curvature and nonspecific binding due to excluded-volume effects among colloidal particles inside lipid bilayer vesicles. We trapped submicron spheres of two different sizes inside a pear-shaped, multilamellar vesicle
A. D. Dinsmore, A. D. Dinsmore, A. D. Dinsmore, A. D. Dinsmore, A. G. Yodh, A. Imhof, A. Milling, A. P. Minton, A. P. Minton, A. Vrij, C. R. Safinya, D. L. Sober, D. T. Wong, E. Evans, E. Sackmann, J. Bibette, J. C. Crocker, J. C. Crocker, J. Y. Walz, P. B. Canham, P. Bartlett, P. D. Kaplan, P. D. Kaplan, Philip Nelson, R. Dickman, R. Lipowsky, R. Lipowsky, R. Lipowsky, S. Asakura, S. M. Ilett, U. Seifert, U. Seifert, U. Seifert, U. Steiner, W. C. K. Poon, W. Helfrich, W. Helfrich, Y. N. Ohshima   +37 more
core   +3 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Estrogen induces two distinct cholesterol crystallization pathways by activating ERα and GPR30 in female mice

Journal of Lipid Research, 2015
To distinguish the lithogenic effect of the classical estrogen receptor α (ERα) from that of the G protein-coupled receptor 30 (GPR30), a new estrogen receptor, on estrogen-induced gallstones, we investigated the entire spectrum of cholesterol ...
Ornella de Bari, Tony Y. Wang, Min Liu, Piero Portincasa, David Q-H. Wang   +4 more
doaj   +1 more source

Geometry of lipid vesicle adhesion

, 2002
The adhesion of a lipid membrane vesicle to a fixed substrate is examined from a geometrical point of view. This vesicle is described by the Helfrich hamiltonian quadratic in mean curvature; it interacts by contact with the substrate, with an interaction
C. Tordeux, E. Blokhuis, E. Blokhuis, E. Evans, E. Evans, E. Farhi, J. Guven, M. Bowick, M. Kraus, P. Canham, P. Swain, R. Capovilla, R. Capovilla, R. Capovilla, R. Goetz, R. Rosso, R. Servuss, S. Svetina, U. Seifert, U. Seifert, W. Helfrich   +20 more
core   +1 more source

Two-dimensional Vesicle dynamics under shear flow: effect of confinement [PDF]

, 2011
Dynamics of a single vesicle under shear flow between two parallel plates is studied using two-dimensional lattice-Boltzmann simulations. We first present how we adapted the lattice-Boltzmann method to simulate vesicle dynamics, using an approach known ...
Badr Kaoui, C. Pozrikidis, Chaouqi Misbah, Jens Harting, M. C. Sukop, R. Lipowsky, S. Succi, W. Helfrich, Y. C. Fung   +8 more
core   +3 more sources