Results 191 to 200 of about 131,357 (307)

Dual-Ring SNAREpin Machinery Tuning for Fast Synaptic Vesicle Fusion. [PDF]

Biomolecules
Caruel M, Pincet F.
europepmc   +1 more source

In vitro single vesicle fusion assays based on pore-spanning membranes: merits and drawbacks. [PDF]

Eur Biophys J, 2021
Mühlenbrock P, Sari M, Steinem C.
europepmc   +1 more source

Neonatal anesthesia impairs synapsin 1 and synaptotagmin 1, two key regulators of synaptic vesicle docking and fusion

, 2019
Navya Atluri, Bianca Ferrarese, Hari Prasad Osuru, Ryan Sica, Caroline Gubser Keller, Zhiyi Zuo, Nadia Lunardi   +6 more
openalex   +2 more sources

CRACM3 regulates the stability of non-excitable exocytotic vesicle fusion pores in a Ca2+-independent manner via molecular interaction with syntaxin4 [PDF]

, 2016
Shuang Liu, Muhammad Novrizal Abdi Sahid, Erika Takemasa, Takeshi Kiyoi, Miyuki Kuno, Yusuke Oshima, Kazutaka Maeyama   +6 more
openalex   +1 more source

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

Mutations of Single Residues in the Complexin N-terminus Exhibit Distinct Phenotypes in Synaptic Vesicle Fusion. [PDF]

J Neurosci
Toulme E, Murach J, Bärfuss S, Kroll J, Malsam J, Trimbuch T, Herman MA, Söllner TH, Rosenmund C.   +8 more
europepmc   +1 more source

Nanoscale Mapping of the Subcellular Glycosylation Landscape

Advanced Science, EarlyView.
Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter, Steffen Sass, Mike Heilemann, Thomas Kuner, Maja Klevanski   +4 more
wiley   +1 more source

Vesicle-vesicle fusion promoted by the Atg8-family autophagy protein LC3C: relevance of the N-terminal region. [PDF]

Autophagy
Ballesteros U, Alonso A, Montes LR, Etxaniz A.   +3 more
europepmc   +1 more source

GTP Hydrolysis of TC10 Promotes Neurite Outgrowth through Exocytic Fusion of Rab11- and L1-Containing Vesicles by Releasing Exocyst Component Exo70

, 2013
Akane Fujita, Shingo Koinuma, Sayaka Yasuda, Hiroyuki Nagai, Hiroyuki Kamiguchi, Naoyuki Wada, Takeshi Nakamura   +6 more
openalex   +2 more sources

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source