Vesicle fusion and release in neurons under dynamic mechanical equilibrium. [PDF]
Liu W, Gao T, Li N, Shao S, Liu B.
europepmc +1 more source
Reexamination of N-terminal domains of syntaxin-1 in vesicle fusion from central murine synapses. [PDF]
Vardar G+7 more
europepmc +1 more source
Drosophila CAPS Is an Essential Gene that Regulates Dense-Core Vesicle Release and Synaptic Vesicle Fusion [PDF]
Robert Renden+8 more
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Engineered Foxp1high Exosomes Ameliorates Systemic Lupus Erythematosus
This study presents a dual‐engineering strategy combining mesenchymal stem cell aggregation and Foxp1 overexpression to generate Foxp1high aggregation exosomes with enhanced immunomodulatory properties. These engineered exosomes exhibit immune organ targeting and superior efficacy in systemic lupus erythematosus treatment by promoting Treg ...
Luhan Niu+9 more
wiley +1 more source
Dual-Ring SNAREpin Machinery Tuning for Fast Synaptic Vesicle Fusion. [PDF]
Caruel M, Pincet F.
europepmc +1 more source
Reconstitution of Membrane Proteins into Giant Unilamellar Vesicles via Peptide-Induced Fusion [PDF]
Nicoletta Kahya+4 more
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This study reveals that M2‐EVs mitigate periodontitis‐induced bone resorption by modulating neutrophil fate. Single‐cell RNA sequencing identified an Anxa1hi neutrophil subpopulation with pro‐reparative properties. M2‐EVs disrupt neutrophil maturation, promoting this subpopulation through key reprogramming genes (Acvrl1, Fpr2). These findings highlight
Yufei Yao+7 more
wiley +1 more source
In vitro single vesicle fusion assays based on pore-spanning membranes: merits and drawbacks. [PDF]
Mühlenbrock P, Sari M, Steinem C.
europepmc +1 more source
In this study, a novel mechanism is unveiled by which ADD1, acting as a molecular switch, coordinates actin branch dynamics and the transport of endocytic viruses and cargoes. Phosphorylation of ADD1 at Ser726 reduces actin branch density, enhancing endosome fusion and attachment to microtubules.
Meijun Jiang+10 more
wiley +1 more source
Mutations of Single Residues in the Complexin N-terminus Exhibit Distinct Phenotypes in Synaptic Vesicle Fusion. [PDF]
Toulme E+8 more
europepmc +1 more source