Results 261 to 270 of about 131,357 (307)
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A Detailed Look at Vesicle Fusion
The Journal of Physical Chemistry B, 2006Many different hypotheses on the molecular mechanisms of vesicle fusion exist. Because these mechanisms cannot be readily asserted experimentally, we address the problem by a coarse-grained molecular dynamics simulations study and compare the results with the results of other techniques.
Smeijers, A.F. +3 more
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SNARE Proteins in Synaptic Vesicle Fusion
2023Neurotransmitters are stored in small membrane-bound vesicles at synapses; a subset of synaptic vesicles is docked at release sites. Fusion of docked vesicles with the plasma membrane releases neurotransmitters. Membrane fusion at synapses, as well as all trafficking steps of the secretory pathway, is mediated by SNARE proteins.
Mark T, Palfreyman +2 more
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Programmed Vesicle Fusion Triggers Gene Expression
Langmuir, 2011The membrane properties of phospholipid vesicles can be manipulated to both regulate and initiate encapsulated biochemical reactions and networks. We present evidence for the inhibition and activation of reactions encapsulated in vesicles by the exogenous addition of charged amphiphiles.
Caschera, Filippo +5 more
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Reconstituting Synaptic Vesicle Fusion
Science Signaling, 2013A model of neurotransmitter release explains why two proteins not needed for membrane fusion in vitro are needed in vivo.
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Fusion pore regulation in peptidergic vesicles
Cell Calcium, 2012Regulated exocytosis, which involves fusion of secretory vesicles with the plasma membrane, is an important mode of communication between cells. In this process, signalling molecules that are stored in secretory vesicles are released into the extracellular space.
Jernej, Jorgačevski +3 more
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Mechanics of post-fusion exocytotic vesicle
Physical Biology, 2017Exocytosis is an important cellular process controlled by metabolic signaling. It involves vesicle fusion to the plasma membrane, followed by the opening of a fusion pore, and the subsequent release of the vesicular lumen content into the extracellular space.
Thomas, Stephens +2 more
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Synaptic vesicle docking and fusion
Current Opinion in Neurobiology, 1999Neurotransmitter secretion shares many features with constitutive membrane trafficking. In both cases, vesicles are targeted to a specific acceptor membrane and fuse via a series of protein-protein interactions. Recent work has added to the list of protein complexes involved and is beginning to define the order in which they act.
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Fusion pore stability of peptidergic vesicles
Molecular Membrane Biology, 2010It is believed that in regulated exocytosis the vesicle membrane fuses with the plasma membrane in response to a physiological stimulus. However, in the absence of stimulation, repetitive transient fusion events are also observed, reflecting a stable state. The mechanisms by which the initial fusion pore attains stability are poorly understood.
Jernej, Jorgacevski +8 more
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Vesicle fusion from yeast to man
Nature, 1994Membrane budding and fusion occur in all eukaryotic cells. Their underlying mechanisms have been studied in mammalian neurons and in yeast, a simple eukaryote. The differences between these two systems would suggest that fusion events in yeast and the neuron would operate by different mechanisms, but recent advances indicate that this is not true.
S, Ferro-Novick, R, Jahn
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Vesicles and Vesicle Fusion: Coarse-Grained Simulations
2012Biological cells are highly dynamic, and continually move material around their own volume and between their interior and exterior. Much of this transport encapsulates the material inside phospholipid vesicles that shuttle to and from, fusing with, and budding from, other membranes.
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