Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion [PDF]
Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites
A Fomovska +54 more
core +2 more sources
Structures of yeast vesicle trafficking proteins [PDF]
AbstractIn protein transport between organelles, interactions of v‐ and t‐SNARE proteins are required for fusion of proteincontaining vesicles with appropriate target compartments. Mammalian SNARE proteins have been observed to interact with NSF and SNAP, and yeast SNAREs with yeast homologues of NSF and SNAP proteins.
Tishgarten, T +7 more
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Cell polarity and patterning by PIN trafficking through early endosomal compartments in Arabidopsis thaliana [PDF]
PIN-FORMED (PIN) proteins localize asymmetrically at the plasma membrane and mediate intercellular polar transport of the plant hormone auxin that is crucial for a multitude of developmental processes in plants.
De Rycke, Riet +8 more
core +14 more sources
Getting Sugar Coating Right! The Role of the Golgi Trafficking Machinery in Glycosylation
The Golgi is the central organelle of the secretory pathway and it houses the majority of the glycosylation machinery, which includes glycosylation enzymes and sugar transporters. Correct compartmentalization of the glycosylation machinery is achieved by
Zinia D’Souza +3 more
doaj +1 more source
The SNARE Protein Syntaxin 3 Confers Specificity for Polarized Axonal Trafficking in Neurons. [PDF]
Cell polarity and precise subcellular protein localization are pivotal to neuronal function. The SNARE machinery underlies intracellular membrane fusion events, but its role in neuronal polarity and selective protein targeting remain unclear.
Albertolle, Mary E +7 more
core +1 more source
Subcellular trafficking of the Arabidopsis auxin influx carrier AUX1 uses a novel pathway distinct from PIN1 [PDF]
The directional flow of the plant hormone auxin mediates multiple developmental processes, including patterning and tropisms. Apical and basal plasma membrane localization of AUXIN-RESISTANT1 (AUX1) and PIN-FORMED1 (PIN1) auxin transport components ...
Bennett, Malcolm +4 more
core +2 more sources
CK2 phosphorylates Sec31 and regulates ER-To-Golgi trafficking. [PDF]
Protein export from the endoplasmic reticulum (ER) is an initial and rate-limiting step of molecular trafficking and secretion. This is mediated by coat protein II (COPII)-coated vesicles, whose formation requires small GTPase Sar1 and 6 Sec proteins ...
Mayuko Koreishi +4 more
doaj +1 more source
Phospholipase A2-based probes to study vesicle trafficking. [PDF]
Vesicle exo- and endocytosis mediate important biological functions, including synaptic transmission. In this issue of Cell Reports Methods, Seong J. An et al. found that the fluorescently tagged C2 domain of phospholipase A2 binds to membrane phosphatidylcholine and thus labels vesicle membrane, allowing for super-resolution and electron microscopic ...
Wang X, Sun M, Chan CY, Wu LG.
europepmc +3 more sources
Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. [PDF]
Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the ...
Crawford, Sue E. +4 more
core +2 more sources
Vesicle Trafficking: A Rab Family Profile [PDF]
A new tool-kit has been developed for profiling expression and function of Rab GTPases on a genome-wide scale. Use of this tool-kit has revealed unexpectedly that at least half of Drosophila Rabs have neuronal-specific expression patterns and localize to synapses.
Harris, Kathryn P., Littleton, J. Troy
openaire +3 more sources

