Results 31 to 40 of about 99,455 (245)
Structures of yeast vesicle trafficking proteins [PDF]
Protein Science, 1999 AbstractIn protein transport between organelles, interactions of v‐ and t‐SNARE proteins are required for fusion of proteincontaining vesicles with appropriate target compartments. Mammalian SNARE proteins have been observed to interact with NSF and SNAP, and yeast SNAREs with yeast homologues of NSF and SNAP proteins.
Tishgarten, T +7 more
openaire +3 more sources
Viral Components Trafficking with(in) Extracellular Vesicles
Viruses, 2023 The global public health burden exerted by viruses partially stems from viruses’ ability to subdue host cells into creating an environment that promotes their multiplication (i.e., pro-viral). It has been discovered that viruses alter cell physiology by transferring viral material through extracellular vesicles (EVs), which serve as vehicles for ...
Rey-Cadilhac, Félix +3 more
openaire +4 more sources
Cell Reports, 2017 Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) signaling is transient and spatially confined in live cells. How this pattern of signaling regulates transmitter release and hormone secretion has not been addressed. We devised an optogenetic approach to
Chen Ji, Fan Fan, Xuelin Lou
doaj +1 more source
LRRK2 Modulates the Exocyst Complex Assembly by Interacting with Sec8
Cells, 2021 Mutations in LRRK2 play a critical role in both familial and sporadic Parkinson’s disease (PD). Up to date, the role of LRRK2 in PD onset and progression remains largely unknown.
Milena Fais +12 more
doaj +1 more source
Molecular Brain, 2018 Growing evidence has indicated that prefibrillar form of soluble amyloid beta (sAβ1–42) is the major causative factor in the synaptic dysfunction associated with AD.
Daehun Park, Sunghoe Chang
doaj +1 more source
Journal of Fungi, 2022 Microsporidia are a big group of single-celled obligate intracellular organisms infecting most animals and some protozoans. These minimalist eukaryotes lack numerous genes in metabolism and vesicle trafficking.
Jie Chen +11 more
doaj +1 more source
LRRK2: A Problem Lurking in Vesicle Trafficking? [PDF]
Journal of Neuroscience, 2011 Mutations in leucine-rich repeat kinase 2 (LRRK2) are the major genetic cause of Parkinson's disease (PD), accounting for ∼5% of familial and 0.5–2% of sporadic cases ([Dachsel and Farrer, 2010][1]).
Sybille, Dihanich, Claudia, Manzoni
openaire +2 more sources
Ecotoxicology and Environmental Safety, 2023 Cadmium (Cd) is a toxic heavy metal in soil that seriously threatens crop production, food security, and human health. Syntaxins, a prototype family of Soluble N-ethyl-maleimide-associated protein receptors (SNAREs) involved in vesicle trafficking, are ...
Jiayuan Zhang +5 more
doaj +1 more source
Dysregulations of Synaptic Vesicle Trafficking in Schizophrenia [PDF]
Current Psychiatry Reports, 2016 Schizophrenia is a serious psychiatric illness which is experienced by about 1 % of individuals worldwide and has a debilitating impact on perception, cognition, and social function. Over the years, several models/hypotheses have been developed which link schizophrenia to dysregulations of the dopamine, glutamate, and serotonin receptor pathways.
Chijioke N, Egbujo +2 more
openaire +2 more sources
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source