Results 31 to 40 of about 152,465 (288)

Rab GTPases: Central Coordinators of Membrane Trafficking in Cancer

Frontiers in Cell and Developmental Biology, 2021
Tumor progression involves invasion, migration, metabolism, autophagy, exosome secretion, and drug resistance. Cargos transported by membrane vesicle trafficking underlie all of these processes.
Hongyuan Jin, Yuanxin Tang, Liang Yang, Xueqiang Peng, Bowen Li, Qin Fan, Shibo Wei, Shuo Yang, Xinyu Li, Bo Wu, Mingyao Huang, Shilei Tang, Jingang Liu, Hangyu Li   +13 more
doaj   +1 more source

The SNARE Protein Syntaxin 3 Confers Specificity for Polarized Axonal Trafficking in Neurons. [PDF]

, 2016
Cell polarity and precise subcellular protein localization are pivotal to neuronal function. The SNARE machinery underlies intracellular membrane fusion events, but its role in neuronal polarity and selective protein targeting remain unclear.
Albertolle, Mary E, Banna, Chris D, Low, Seng Hui, Radeke, Carolyn M, Sharma, Nikunj, Soo Hoo, Linda, Vandenberg, Carol A, Weimbs, Thomas   +7 more
core   +1 more source

Regulation of plasma membrane expansion during axon formation [PDF]

, 2018
Here, will review current evidence regarding the signaling pathways and mechanisms underlying membrane addition at sites of active growth during axon formation.Fil: Quiroga, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas.
Bisbal, Mariano, Caceres, Alfredo Oscar, Quiroga, Santiago   +2 more
core   +1 more source

The FgVps39-FgVam7-FgSso1 Complex Mediates Vesicle Trafficking and Is Important for the Development and Virulence of Fusarium graminearum

Molecular Plant-Microbe Interactions, 2017
Vesicle trafficking is an important event in eukaryotic organisms. Many proteins and lipids transported between different organelles or compartments are essential for survival.
Bing Li, Luping Liu, Ying Li, Xin Dong, Haifeng Zhang, Huaigu Chen, Xiaobo Zheng, Zhengguang Zhang   +7 more
doaj   +1 more source

Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion [PDF]

, 2013
Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites
A Fomovska, AE Topolska, B Lige, B Shen, BF Kafsack, BJ Luft, C Lord, CA Hunter, Chetan E. Chitnis, Christian Slomianny, CY He, D Richard, DL Alexander, F Parussini, H El Hajj, HC Hoppe, HC Hoppe, I Mellman, J Schrevel, JB Dacks, JC Boothroyd, JE Rothman, JF Dubremetz, JM Harper, K Kremer, K Miranda, KA Joiner, KA Joiner, KM Hager, L Pelletier, L Sheiner, LH Bannister, LH Bannister, LM Kats, M Elias, M Tufet-Bayona, M Yang, Markus Meissner, ME Francia, MH Ngo, MH Ngo, MK Shaw, MS Breinich, MS Marks, NA Counihan, PJ Bradley, PJ Sloves, S Mogelsvang, SD Brydges, Stanislas Tomavo, VB Carruthers, Vern B. Carruthers, WM Henne, X Que, Z Dou   +54 more
core   +2 more sources

MUNC18–1 gene abnormalities are involved in neurodevelopmental disorders through defective cortical architecture during brain development

Acta Neuropathologica Communications, 2017
While Munc18–1 interacts with Syntaxin1 and controls the formation of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) complex to regulate presynaptic vesicle fusion in developed neurons, this molecule is likely to be ...
Nanako Hamada, Ikuko Iwamoto, Hidenori Tabata, Koh-ichi Nagata   +3 more
doaj   +1 more source

A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis. [PDF]

PLoS Biology, 2017
Ion homeostasis is essential for plant growth and environmental adaptation, and maintaining ion homeostasis requires the precise regulation of various ion transporters, as well as correct root patterning.
Yi-Qun Gao, Jiu-Geng Chen, Zi-Ru Chen, Dong An, Qiao-Yan Lv, Mei-Ling Han, Ya-Ling Wang, David E Salt, Dai-Yin Chao   +8 more
doaj   +1 more source

Effects of Excess Brain-Derived Human α-Synuclein on Synaptic Vesicle Trafficking

Frontiers in Neuroscience, 2021
α-Synuclein is a presynaptic protein that regulates synaptic vesicle trafficking under physiological conditions. However, in several neurodegenerative diseases, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy, α ...
Cristina Román-Vendrell, Audrey T. Medeiros, John B. Sanderson, Haiyang Jiang, Tim Bartels, Jennifer R. Morgan   +5 more
doaj   +1 more source

Dynamic L-type CaV1.2 channel trafficking facilitates CaV1.2 clustering and cooperative gating. [PDF]

, 2018
L-type CaV1.2 channels are key regulators of gene expression, cell excitability and muscle contraction. CaV1.2 channels organize in clusters throughout the plasma membrane.
Brust-Mascher, Ingrid, Dixon, Rose E, Ghosh, Debapriya, Hell, Johannes W, Horne, Mary C, Navedo, Manuel F, Nieves-Cintrón, Madeline, Santana, Luis F, Tajada, Sendoa   +8 more
core   +2 more sources

LRRK2 Modulates the Exocyst Complex Assembly by Interacting with Sec8

Cells, 2021
Mutations in LRRK2 play a critical role in both familial and sporadic Parkinson’s disease (PD). Up to date, the role of LRRK2 in PD onset and progression remains largely unknown.
Milena Fais, Giovanna Sanna, Manuela Galioto, Thi Thanh Duyen Nguyen, Mai Uyên Thi Trần, Paola Sini, Franco Carta, Franco Turrini, Yulan Xiong, Ted M. Dawson, Valina L. Dawson, Claudia Crosio, Ciro Iaccarino   +12 more
doaj   +1 more source