Results 41 to 50 of about 99,455 (245)

Selenoprotein K contributes to CD36 subcellular trafficking in hepatocytes by accelerating nascent COPII vesicle formation and aggravates hepatic steatosis

Redox Biology, 2022
SelenoproteinK (SelK), an endoplasmic reticulum (ER) - resident protein, possesses the property of mediate oxidation resistance and ER - associated protein degradation (ERAD) in several tissues.
Mengyue You, Fan Wu, Meilin Gao, Mengyue Chen, Shu Zeng, Yang Zhang, Wei Zhao, Danyang Li, Li Wei, Xiong Z. Ruan, Yaxi Chen   +10 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Uncovering the Mechanisms of Intracellular Membrane Trafficking by Reconstituted Membrane Systems

Membranes
Intracellular membrane trafficking that transports proteins, lipids, and other substances between organelles is crucial for maintaining cellular homeostasis and signal transduction. The imbalance of membrane trafficking leads to various diseases.
Shuhan Chen, Yinghui Liu, Haijia Yu
doaj   +1 more source

LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization. [PDF]

PLoS ONE, 2013
The leucine-rich repeat kinase 2 (LRRK2) gene was found to play a role in the pathogenesis of both familial and sporadic Parkinson's disease (PD). LRRK2 encodes a large multi-domain protein that is expressed in different tissues.
Rossana Migheli, Maria Grazia Del Giudice, Ylenia Spissu, Giovanna Sanna, Yulan Xiong, Ted M Dawson, Valina L Dawson, Manuela Galioto, Gaia Rocchitta, Alice Biosa, Pier Andrea Serra, Maria Teresa Carri, Claudia Crosio, Ciro Iaccarino   +13 more
doaj   +1 more source

Vesicle Trafficking: A Rab Family Profile [PDF]

Current Biology, 2011
A new tool-kit has been developed for profiling expression and function of Rab GTPases on a genome-wide scale. Use of this tool-kit has revealed unexpectedly that at least half of Drosophila Rabs have neuronal-specific expression patterns and localize to synapses.
Harris, Kathryn P., Littleton, J. Troy
openaire   +4 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Vesicle Trafficking: ROP–RIC Roundabout [PDF]

Current Biology, 2012
Mechanisms governing dynamic protein recycling include small GTPases that activate/inactivate their partner proteins to affect cytoskeletal dynamics, and thereby polar growth, asymmetric cell shape and physiological responses to external stimuli. Three recent studies illustrate the control of PIN endocytosis by ROP-RIC activity in leaf pavement cells ...
Murphy, Angus S., Peer, Wendy Ann
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Hypothesis Relating the Structure, Biochemistry and Function of Active Zone Material Macromolecules at a Neuromuscular Junction

Frontiers in Synaptic Neuroscience, 2022
This report integrates knowledge of in situ macromolecular structures and synaptic protein biochemistry to propose a unified hypothesis for the regulation of certain vesicle trafficking events (i.e., docking, priming, Ca2+-triggering, and membrane fusion)
Joseph A. Szule
doaj   +1 more source

Regulated Exocytosis and Vesicle Trafficking in Astrocytes

Annals of the New York Academy of Sciences, 2009
Astrocytes are increasingly viewed as crucial cells supporting and integrating brain functions. It is thought that the release of gliotransmitters into the extracellular space by regulated exocytosis supports a significant part of communication between astrocytes and neurons.
Kreft, Marko, Potokar, Maja, Stenovec, Matjaž, Pangršič, T., Zorec, Robert   +4 more
openaire   +3 more sources