Results 21 to 30 of about 99,455 (245)
Getting Sugar Coating Right! The Role of the Golgi Trafficking Machinery in Glycosylation
Cells, 2021 The Golgi is the central organelle of the secretory pathway and it houses the majority of the glycosylation machinery, which includes glycosylation enzymes and sugar transporters. Correct compartmentalization of the glycosylation machinery is achieved by
Zinia D’Souza +3 more
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Rab-mediated vesicle trafficking in cancer [PDF]
Journal of Biomedical Science, 2016 A large group of small Rab GTPases which mediate secretory and endosomal membrane transport, as well as autophagosome biogenesis, are essential components of vesicle trafficking machinery. Specific Rab protein together with the cognate effectors coordinates the dynamics of trafficking pathway and determines the cargo proteins destination.
Tzeng, Hong-Tai, Wang, Yi-Ching
openaire +2 more sources
Neurobiology of Disease, 2003 Loss of synapses correlates with cognitive decline in Alzheimer’s disease (AD). However, molecular mechanisms underlying the synaptic dysfunction and loss are not well understood.
Pamela J Yao +6 more
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CK2 phosphorylates Sec31 and regulates ER-To-Golgi trafficking. [PDF]
PLoS ONE, 2013 Protein export from the endoplasmic reticulum (ER) is an initial and rate-limiting step of molecular trafficking and secretion. This is mediated by coat protein II (COPII)-coated vesicles, whose formation requires small GTPase Sar1 and 6 Sec proteins ...
Mayuko Koreishi +4 more
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Bio-Protocol, 2021 More than 30% of the total amount of proteins synthesized in mammalian cells follow the secretory pathway in order to mature and be properly sorted to their final destinations.
Mehrshad Pakdel +2 more
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Rab GTPases: Central Coordinators of Membrane Trafficking in Cancer
Frontiers in Cell and Developmental Biology, 2021 Tumor progression involves invasion, migration, metabolism, autophagy, exosome secretion, and drug resistance. Cargos transported by membrane vesicle trafficking underlie all of these processes.
Hongyuan Jin +13 more
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Molecular Plant-Microbe Interactions, 2017 Vesicle trafficking is an important event in eukaryotic organisms. Many proteins and lipids transported between different organelles or compartments are essential for survival.
Bing Li +7 more
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Acta Neuropathologica Communications, 2017 While Munc18–1 interacts with Syntaxin1 and controls the formation of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) complex to regulate presynaptic vesicle fusion in developed neurons, this molecule is likely to be ...
Nanako Hamada +3 more
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A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis. [PDF]
PLoS Biology, 2017 Ion homeostasis is essential for plant growth and environmental adaptation, and maintaining ion homeostasis requires the precise regulation of various ion transporters, as well as correct root patterning.
Yi-Qun Gao +8 more
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Effects of Excess Brain-Derived Human α-Synuclein on Synaptic Vesicle Trafficking
Frontiers in Neuroscience, 2021 α-Synuclein is a presynaptic protein that regulates synaptic vesicle trafficking under physiological conditions. However, in several neurodegenerative diseases, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy, α ...
Cristina Román-Vendrell +5 more
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