Results 51 to 60 of about 151,771 (292)

Oxysterol-Binding Protein-1 (OSBP1) Modulates Processing and Trafficking of the Amyloid Precursor Protein [PDF]

, 2008
BACKGROUND Evidence from biochemical, epidemiological and genetic findings indicates that cholesterol levels are linked to amyloid-β (Aβ) production and Alzheimer's disease (AD). Oxysterols, which are cholesterol-derived ligands of the liver X receptors
Abraham, Carmela R., Chen, Ci-Di, Cordy, Joanna M., Guillily, Maria, Ray, William J., Seabrook, Guy R., Suon, Sokreine, Wolozin, Benjamin, Zerbinatti, Celina V.   +8 more
core   +4 more sources

Epithelial organization and cyst lumen expansion require efficient Sec13-Sec31-driven secretion [PDF]

, 2012
Epithelial morphogenesis is directed by interactions with the underlying extracellular matrix. Secretion of collagen and other matrix components requires efficient coat complex II (COPII) vesicle formation at the endoplasmic reticulum. Here, we show that
Hodgson, Lorna, Schmidt, Katy, Stephens, David J, Townley, Anna K   +3 more
core   +2 more sources

Synapsin Isoforms and Synaptic Vesicle Trafficking

Molecules and Cells, 2015
Synapsins were the first presynaptic proteins identified and have served as the flagship of the presynaptic protein field. Here we review recent studies demonstrating that different members of the synapsin family play different roles at presynaptic terminals employing different types of synaptic vesicles.
Song, Sang-Ho, Augustine, George J.
openaire   +3 more sources

Parkinson's: A Disease of Aberrant Vesicle Trafficking [PDF]

Annual Review of Cell and Developmental Biology, 2020
Parkinson's disease (PD) is a leading cause of neurodegeneration that is defined by the selective loss of dopaminergic neurons and the accumulation of protein aggregates called Lewy bodies (LBs). The unequivocal identification of Mendelian inherited mutations in 13 genes in PD has provided transforming insights into the pathogenesis of this disease ...
Singh, Pawan Kishor, Muqit, Miratul M. K.   +1 more
openaire   +3 more sources

Selenoprotein K contributes to CD36 subcellular trafficking in hepatocytes by accelerating nascent COPII vesicle formation and aggravates hepatic steatosis

Redox Biology, 2022
SelenoproteinK (SelK), an endoplasmic reticulum (ER) - resident protein, possesses the property of mediate oxidation resistance and ER - associated protein degradation (ERAD) in several tissues.
Mengyue You, Fan Wu, Meilin Gao, Mengyue Chen, Shu Zeng, Yang Zhang, Wei Zhao, Danyang Li, Li Wei, Xiong Z. Ruan, Yaxi Chen   +10 more
doaj   +1 more source

Defective axonal transport in motor neuron disease [PDF]

, 2007
Several recent studies have highlighted the role of axonal transport in the pathogenesis of motor neuron diseases. Mutations in genes that control microtubule regulation and dynamics have been shown to cause motor neuron degeneration in mice and in a ...
Baas, Blair, Boillee, Bommel, Borchelt, Bowling, Brown, Bruijn, Burger, Cao, Cleveland, Cleveland, Duchen, Escurat, Evans, Fichera, Fliegner, Gaudette, Goldstein, Hadano, Hafezparast, Hazan, Hirokawa, Hirokawa, Hirokawa, Jablonka, Joshi, Kanai, Kaplan, Kieran, King, Kong, LaMonte, Levy, Ligon, Liu, Lo Giudice, Lu, Martin, Miki, Miki, Mitsumoto, Mitsumoto, Muglia, Munch, Nicholson, Nishimura, Okabe, Otomo, Parkinson, Parysek, Pasinelli, Patel, Proukakis, Puls, Puls, Quenneville, Rao, Reid, Reid, Reid, Rosen, Ross, Rowland, Sanderson, Schmitt-John, Shaw, Shibata, Siegel, Song, Teuchert, Troy, Vallee, Weber, Williamson, Wood, Xia, Zhao   +77 more
core   +1 more source

Proteins involved in synaptic vesicle trafficking

The Journal of Physiology, 1999
Neurotransmitter release relies on a series of synaptic vesicle trafficking reactions. We have determined the molecular basis of these reactions by microinjecting, into ‘giant’ nerve terminals of squid, probes that interfere with presynaptic proteins. These probes affect neurotransmitter release and disrupt nerve terminal structure.
G J, Augustine, M E, Burns, W M, DeBello, S, Hilfiker, J R, Morgan, F E, Schweizer, H, Tokumaru, K, Umayahara   +7 more
openaire   +3 more sources

Trafficking of astrocytic vesicles in hippocampal slices [PDF]

Biochemical and Biophysical Research Communications, 2009
The increasingly appreciated role of astrocytes in neurophysiology dictates a thorough understanding of the mechanisms underlying the communication between astrocytes and neurons. In particular, the uptake and release of signaling substances into/from astrocytes is considered as crucial.
Maja, Potokar, Marko, Kreft, So-Young, Lee, Hajime, Takano, Philip G, Haydon, Robert, Zorec   +5 more
openaire   +2 more sources

Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation. [PDF]

, 2001
Recent studies indicate that insulin stimulation of glucose transporter (GLUT)4 translocation requires at least two distinct insulin receptor-mediated signals: one leading to the activation of phosphatidylinositol 3 (PI-3) kinase and the other to the ...
Chiang, SH, Kanzaki, M, Macara, IG, Mora, S, Pessin, JE, Saltiel, AR, Shigematsu, S, Watson, RT   +7 more
core   +3 more sources

Dysregulations of Synaptic Vesicle Trafficking in Schizophrenia [PDF]

Current Psychiatry Reports, 2016
Schizophrenia is a serious psychiatric illness which is experienced by about 1 % of individuals worldwide and has a debilitating impact on perception, cognition, and social function. Over the years, several models/hypotheses have been developed which link schizophrenia to dysregulations of the dopamine, glutamate, and serotonin receptor pathways.
Chijioke N, Egbujo, Duncan, Sinclair, Chang-Gyu, Hahn   +2 more
openaire   +2 more sources