Results 81 to 90 of about 149,274 (318)
Durability of a Vesicular Stomatitis Virus-Based Marburg Virus Vaccine in Nonhuman Primates
PLoS ONE, 2014 The filoviruses, Marburg virus (MARV) and Ebola virus, causes severe hemorrhagic fever with high mortality in humans and nonhuman primates. A promising filovirus vaccine under development is based on a recombinant vesicular stomatitis virus (rVSV) that ...
C. Mire +8 more
semanticscholar +1 more source
Protective Role for Itaconate During Inhaled Allergen Challenge
Allergy, EarlyView.Itaconate levels decrease in sputum following allergen inhalation in mild asthmatics, suggesting a dynamic metabolic response to airway challenge. Genetic deletion of Acod1 in mice did not alter airway inflammation or remodelling in response to chronic HDM exposure.
Gesa J. Albers +16 more
wiley +1 more source
Postexposure Treatment of Marburg Virus Infection
Emerging Infectious Diseases, 2010 Rhesus monkeys are protected from disease when a recombinant vesicular stomatitis virus–based vaccine is administered 20–30 min after infection with Marburg virus.
Thomas W. Geisbert +6 more
doaj +1 more source
Recent optical approaches for anatomical and functional dissection of neuron–astrocyte circuitry
The Journal of Physiology, EarlyView.Abstract figure legend This review summarises novel optical approaches to deciphering structural and functional wiring diagrams of neuron–astrocyte circuits in the brain. There are three groups: the anatomical proximity assay, transsynaptic viral tracing and the functional connection assay. The FRET‐based neuron–astrocyte proximity assay allows mapping
Yoshiki Hatashita, Takafumi Inoue
wiley +1 more source
Pseudotyping exosomes for enhanced protein delivery in mammalian cells. [PDF]
, 2017 Exosomes are cell-derived nanovesicles that hold promise as living vehicles for intracellular delivery of therapeutics to mammalian cells. This potential, however, is undermined by the lack of effective methods to load exosomes with therapeutic proteins ...
Li, Lingxuan +5 more
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Sex Differences in Response to Viral Vector Vaccines—Implications for Future Vaccine Design
Immunological Reviews, Volume 338, Issue 1, March 2026.ABSTRACT Vaccination represents one of the most impactful public health achievements, preventing 3.5 to 5 million deaths annually according to estimates of the World Health Organization. Yet, recent outbreaks of emerging and reemerging infectious diseases highlight the need for rapid and strategic vaccine development using vaccine platforms ...
Ilka Grewe +2 more
wiley +1 more source
Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein
Nature Communications, 2018 Glycoprotein G of vesicular stomatitis virus (VSV) enables viral entry by binding to the major VSV receptor LDL-R. Here the authors present crystal structures of G in complex with two distinct CR domains of LDL-R, identifying structural determinants for ...
Jovan Nikolic +5 more
doaj +1 more source
Transsynaptic Tracing with Vesicular Stomatitis Virus Reveals Novel Retinal Circuitry
Journal of Neuroscience, 2013 The use of neurotropic viruses as transsynaptic tracers was first described in the 1960s, but only recently have such viruses gained popularity as a method for labeling neural circuits.
Kevin T. Beier +5 more
semanticscholar +1 more source
TRIM41-Mediated Ubiquitination of Nucleoprotein Limits Vesicular Stomatitis Virus Infection
Viruses, 2020 Vesicular stomatitis virus (VSV) is a zoonotic, negative-stranded RNA virus of the family Rhabdoviridae. The nucleoprotein (N) of VSV protects the viral genomic RNA and plays an essential role in viral transcription and replication, which makes the ...
Girish Patil +7 more
doaj +1 more source
5'-terminal structure of poliovirus polyribosomal RNA is pUp [PDF]
, 1976 Poliovirus RNA purified from virus-specific polyribosomes does not contain m7G in a 5'-5'-pyrophosphate linkage at its 5'-end. The only potential 5'-end found in ribonuclease digests of this RNA is pUp, which is present in a yield of 1 mole/mole of ...
Baltimore, David +2 more
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