Results 81 to 90 of about 24,925 (205)
Small-Molecule Probes Targeting the Viral PPxY-Host Nedd4 Interface Block Egress of a Broad Range of RNA Viruses. [PDF]
, 2014 Budding of filoviruses, arenaviruses, and rhabdoviruses is facilitated by subversion of host proteins, such as Nedd4 E3 ubiquitin ligase, by viral PPxY late (L) budding domains expressed within the matrix proteins of these RNA viruses.
Davis, Benjamin +11 more
core +2 more sources
Using Vesicular Stomatitis Virus as a Platform for Directed Protease Evolution
Current Protocols, Volume 4, Issue 12, December 2024.Abstract Antiviral drugs are essential medications to save the lives of infected people. However, they are under constant threat to become ineffective as viruses evolve quickly. Studying the development of resistance is therefore paramount to understand the impact of mutations on pharmacological treatment and to make informed decisions.
Francesco Costacurta +3 more
wiley +1 more source
Mass spectrometry analysis reveals differences in the host cell protein species found in pseudotyped lentiviral vectors [PDF]
, 2018 Lentiviral vectors (LVs) have been successfully used in clinical trials showing long term therapeutic benefits. Studying the role of cellular proteins in lentivirus HIV-1 life cycle can help understand virus assembly and budding, leading to improvement ...
Collins, M +5 more
core +1 more source
Vesicular Stomatitis Virus as a Platform for Protease Activity Measurements
Current Protocols, Volume 4, Issue 11, November 2024.Abstract Protease inhibitors are among the most powerful antiviral drugs. They have been used successfully against viruses, such as the human immunodeficiency virus (HIV), hepatitis C virus (HCV) and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2).
Stefanie Rauch +3 more
wiley +1 more source
A PERSPECTIVE CULTURAL MODEL FOR CONTROL OF BIOLOGICAL ACTIVITY OF HUMAN INTERFERONS
Журнал микробиологии, эпидемиологии и иммунобиологии, 2015 Aim. Study species specificity of human lymphocyte interferon alpha in vitro in cell cultures of swine origin for expansion of cell line spectrum for interferon titration and control of newly created interferons and interferon-like preparations in vivo ...
F. G Nagieva +5 more
doaj
Journal of General Virology, 1973 Summary The plasma membranes of BHK 21 cells infected with vesicular stomatitis virus react in complement-fixation tests with antiserum to uninfected BHK 21 cells and with antiserum to the glycosylated ‘spike’ protein found on the surface of the virus (protein G).
openaire +2 more sources
Vaccine process technology—A decade of progress
Biotechnology and Bioengineering, Volume 121, Issue 9, Page 2604-2635, September 2024.Abstract In the past decade, new approaches to the discovery and development of vaccines have transformed the field. Advances during the COVID‐19 pandemic allowed the production of billions of vaccine doses per year using novel platforms such as messenger RNA and viral vectors.
Barry Buckland +8 more
wiley +1 more source
Xenotransplantation, Volume 31, Issue 3, May/June 2024.Abstract Background The German Xenotransplantation Consortium is in the process to prepare a clinical trial application (CTA) on xenotransplantation of genetically modified pig hearts. In the CTA documents to the central and national regulatory authorities, that is, the European Medicines Agency (EMA) and the Paul Ehrlich Institute (PEI), respectively,
Joachim Denner
wiley +1 more source
International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors
International Forum of Allergy &Rhinology, Volume 14, Issue 2, Page 149-608, February 2024.Abstract Background Sinonasal neoplasms, whether benign and malignant, pose a significant challenge to clinicians and represent a model area for multidisciplinary collaboration in order to optimize patient care. The International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors (ICSNT) aims to summarize the best available evidence and ...
Edward C. Kuan +158 more
wiley +1 more source
Genome-wide RNAi screen identifies broadly-acting host factors that inhibit arbovirus infection [PDF]
, 2014 Vector-borne viruses are an important class of emerging and re-emerging pathogens; thus, an improved understanding of the cellular factors that modulate infection in their respective vertebrate and insect hosts may aid control efforts.
Cherry, Sara +8 more
core +4 more sources