Aspects of a Methodological Approach to Determination of Interferon Alpha Specific Activity
Specific antiviral activity is one of the key indicators characterising pharmaceutical quality and pharmacological efficacy of interferon alpha products (IFN-α).
M. L. Baykova +4 more
doaj +1 more source
Vesicular stomatitis (VS) is a notifiable disease of livestock affecting cattle, horses, pigs and humans. Vesicular stomatitis virus (VSV) serotypes Indiana and New Jersey are endemic to Central America; however, they also cause sporadic and scattered outbreaks in various countries in South and North America, including the USA.
Igor Morozov +10 more
openaire +2 more sources
IFNα and IFNγ Impede Marek’s Disease Progression [PDF]
Marek’s disease virus (MDV) is an alphaherpesvirus that causes Marek’s disease, a malignant lymphoproliferative disease of domestic chickens. While MDV vaccines protect animals from clinical disease, they do not provide sterilizing immunity and allow ...
Bertzbach, Luca D. +6 more
core +1 more source
Targeting Kupffer cells (KC) with a single intravenous infusion of the oncolytic virus VSV‐M51R rather than VSV‐WT induces effective tumor regression in various types of liver metastatic cancers in mice. VSV‐M51R promotes KC proliferation and enhances their antigen cross‐presentation capacity without compromising viability, leading to the induction of ...
Chen Chen +8 more
wiley +1 more source
Bat airway epithelial cells: a novel tool for the study of zoonotic viruses.
Bats have been increasingly recognized as reservoir of important zoonotic viruses. However, until now many attempts to isolate bat-borne viruses in cell culture have been unsuccessful.
Isabella Eckerle +9 more
doaj +1 more source
Rabies virus matrix protein interplay with elF3, new insights into rabies virus pathogenesis [PDF]
Viral proteins are frequently multifunctional to accommodate the high density of information encoded in viral genomes. Matrix (M) protein of negative-stranded RNA viruses such as Rhabdoviridae is one such example.
Anastassia V. Komarova +52 more
core +1 more source
Engineering a serum-resistant and thermostable vesicular stomatitis virus G glycoprotein for pseudotyping retroviral and lentiviral vectors. [PDF]
Vesicular stomatitis virus G glycoprotein (VSV-G) is the most widely used envelope protein for retroviral and lentiviral vector pseudotyping; however, serum inactivation of VSV-G pseudotyped vectors is a significant challenge for in vivo gene delivery ...
Hwang, B-Y, Schaffer, DV
core
The Morphology of Vesicular Stomatitis Virus (Indiana C) Derived from Chick Embryos or Cultures of BHK21/13 Cells [PDF]
SUMMARY: The virus of vesicular stomatitis is shown to exist as a system of several particle forms. Two major particles, the “bullet” and “cap”, appear in electron micrographs in various states as outer structural layers are absent or lost. High infectivity is not associated with particles of one form.
C J, Bradish, J B, Kirkham
openaire +2 more sources
The Antiviral Activity of Polyphenols
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard +5 more
wiley +1 more source
Comparisons of nucleotide sequences in the genomes of the New Jersey and Indiana serotypes of vesicular stomatitis virus [PDF]
Nucleotide sequences of around 200 residues were determined adjacent to the 3' terminus of the genome RNA of vesicular stomatitis virus, New Jersey serotype, and adjacent to the 3'-terminal polyadenylic acid tract of the N protein mRNA of the same virus.
D J, McGeoch, A, Dolan, C R, Pringle
openaire +2 more sources

