Results 41 to 50 of about 23,388 (157)

Safety and tolerability of HIV-1 multiantigen pDNA vaccine given with IL-12 plasmid DNA via electroporation, boosted with a recombinant vesicular stomatitis virus HIV Gag vaccine in healthy volunteers in a randomized, controlled clinical trial. [PDF]

PLoS ONE, 2018
BACKGROUND:The addition of plasmid cytokine adjuvants, electroporation, and live attenuated viral vectors may further optimize immune responses to DNA vaccines in heterologous prime-boost combinations.
Marnie L Elizaga, Shuying S Li, Nidhi K Kochar, Gregory J Wilson, Mary A Allen, Hong Van N Tieu, Ian Frank, Magdalena E Sobieszczyk, Kristen W Cohen, Brittany Sanchez, Theresa E Latham, David K Clarke, Michael A Egan, John H Eldridge, Drew Hannaman, Rong Xu, Ayuko Ota-Setlik, M Juliana McElrath, Christine Mhorag Hay, NIAID HIV Vaccine Trials Network (HVTN) 087 Study Team   +19 more
doaj   +1 more source

Risk of infection of dairy cattle in the EU with highly pathogenic avian influenza virus affecting dairy cows in the United States of America (H5N1, Eurasian lineage goose/Guangdong clade 2.3.4.4b. genotype B3.13)

EFSA Journal, Volume 23, Issue 12, December 2025.
Abstract This opinion assesses the risk of avian influenza H5N1 B3.13 genotype virus infection in EU dairy cattle. Introduction of the virus into EU dairy cattle, poultry or wild birds via trade or migratory birds from the US is assessed as highly unlikely.
EFSA Panel on Animal Health and Welfare (AHAW), Julio Alvarez, Anette Ella Boklund, Sabine Dippel, Fernanda Dórea, Jordi Figuerola, Mette S. Herskin, Virginie Michel, Miguel Ángel Miranda Chueca, Eleonora Nannoni, Søren Saxmose Nielsen, Romolo Nonno, Anja B. Riber, Jan Arend Stegeman, Karl Ståhl, Hans‐Hermann Thulke, Frank Tuyttens, Christoph Winckler, Alessio Bortolami, Mariette Ducatez, Claire Guinat, Elsayed M. Abdelwhab, Laurent Guillier, Maarten Nauta, Photis Papademas, Elisabetta Suffredini, Winy Messens, Alessandro Broglia, Helene Jensen, Kamela Kryemadhi, Andrea Gervelmeyer   +30 more
wiley   +1 more source

Use of Heterologous Vesiculovirus G Proteins Circumvents the Humoral Anti-envelope Immunity in Lentivector-Based In Vivo Gene Delivery

Molecular Therapy: Nucleic Acids, 2019
Vesicular stomatitis virus Indiana strain glycoprotein (VSVind.G) mediates broad tissue tropism and efficient cellular uptake. Lentiviral vectors (LVs) are particularly promising, as they can efficiently transduce non-dividing cells and facilitate stable
Altar M. Munis, Giada Mattiuzzo, Emma M. Bentley, Mary K. Collins, James E. Eyles, Yasuhiro Takeuchi   +5 more
doaj   +1 more source

Aspects of a Methodological Approach to Determination of Interferon Alpha Specific Activity

Биопрепараты: Профилактика, диагностика, лечение, 2020
Specific antiviral activity is one of the key indicators characterising pharmaceutical quality and pharmacological efficacy of interferon alpha products (IFN-α).
M. L. Baykova, I. M. Shcherbachenko, L. A. Gayderova, O. B. Ustinnikova, A. A. Movsesyants   +4 more
doaj   +1 more source

Viral‐Directed Augmentation of Kupffer Cell Cross‐Presentation Provokes Antitumor Immunity Against Liver Metastasis

Advanced Science, Volume 12, Issue 39, October 20, 2025.
Targeting Kupffer cells (KC) with a single intravenous infusion of the oncolytic virus VSV‐M51R rather than VSV‐WT induces effective tumor regression in various types of liver metastatic cancers in mice. VSV‐M51R promotes KC proliferation and enhances their antigen cross‐presentation capacity without compromising viability, leading to the induction of ...
Chen Chen, Qing Zhang, Jiajia Li, Xia Zhou, Daxing Gao, Lu Li, Dabing Huang, Jizhou Wang, Zhutian Zeng   +8 more
wiley   +1 more source

Comparison of antiviral activity of extracts from transgenic chicory, lactuca and marshmallow plants

Фактори експериментальної еволюції організмів, 2013
Aim. Comparison of antiviral activity effectiveness (suppression of vesicular stomatitis virus Indiana strain in bovine kidney cell line MDBK) by extracts from transgenic roots of lettuce, chicory and marshmallow with ifn-α2b gene was done. Methods. The
N. A. Matvieieva, Yu. I. Kudryavets, O. O. Lichova, O. Yu. Kvasko, A. M. Shachovsky   +4 more
doaj  

Bat airway epithelial cells: a novel tool for the study of zoonotic viruses.

PLoS ONE, 2014
Bats have been increasingly recognized as reservoir of important zoonotic viruses. However, until now many attempts to isolate bat-borne viruses in cell culture have been unsuccessful.
Isabella Eckerle, Lukas Ehlen, René Kallies, Robert Wollny, Victor M Corman, Veronika M Cottontail, Marco Tschapka, Samuel Oppong, Christian Drosten, Marcel A Müller   +9 more
doaj   +1 more source

Monoclonal antibodies to the M protein of vesicular stomatitis virus (Indiana serotype) and to a cDNA M gene expression product [PDF]

Journal of Virology, 1985
Twenty-nine independent hybridomas producing monoclonal antibodies to the matrix (M) protein of vesicular stomatitis virus (Indiana serotype) were prepared by fusion of SP2/0 myeloma cells with spleen lymphocytes obtained from BALB/c mice which had been immunized with the purified M protein.
R, Pal, B W, Grinnell, R M, Snyder, J R, Wiener, W A, Volk, R R, Wagner   +5 more
openaire   +2 more sources

Comparison of Structural Polypeptides from Vesicular Stomatitis Virus (Indiana and New Jersey Serotypes) and Cocal Virus

Journal of General Virology, 1972
Summary The molecular size of the structural proteins of the Indiana and New Jersey serotypes of vesicular stomatitis virus (VSV) and of Cocal virus have been compared by co-electrophoresis in SDS-polyacrylamide gel. Virus polypeptides (VP) II, III and V of the Indiana serotype have different electrophoretic mobilities from the corresponding components
W H, Wunner, C R, Pringle
openaire   +2 more sources

A Pyrido‐Quinoxaline Derivative That Downregulates Reticulon 3 Protein Exhibits Potent Antiviral Activity Against Zika Virus

Journal of Medical Virology, Volume 97, Issue 9, September 2025.
ABSTRACT In the wake of the COVID‐19 pandemic, awareness of emerging pathogens has significantly increased, prompting greater investment in research and preparedness. In this context, arboviral diseases are recognized as unmet medical challenges due to their rapid spread. Notably, the geographical range of several flaviviral diseases is expanding: Zika
Erika Plicanti, Andrea Deiana, Silvia Nottoli, Giulia Lottini, Roberta Ibba, Sandra Piras, Carlo Di Marzo, Silvia Vegni, Michele Lai, Mauro Pistello, Antonio Carta, Giulia Freer   +11 more
wiley   +1 more source