Results 41 to 50 of about 43,587 (194)

Transplanting neural stem cells overexpressing miRNA‐21 can promote neural recovery after cerebral hemorrhage through the SOX2/LIN28‐let‐7 signaling pathway

Animal Models and Experimental Medicine, EarlyView.
Abstract Background Intracerebral hemorrhage (ICH) remains a devastating neurological disorder with limited therapeutic options. Neural stem cell (NSC)‐based therapies have emerged as a potential regenerative approach, yet the molecular mechanisms regulating NSC behavior require further elucidation.
Wei Dai, Yongxia Li, Jiarui Du, Gang Shen, Meimei Fan, Zuopeng Su, Fulin Xu, Fang Yuan   +7 more
wiley   +1 more source

The Antiviral Activity of Polyphenols

Molecular Nutrition &Food Research, EarlyView.
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu   +5 more
wiley   +1 more source

Producing Vesicular Stomatitis Virus G (VSVG) Protein and Assessment of its Cytotoxic Activity against Breast Cancer Cells

مجله دانشکده پزشکی اصفهان, 2015
Background: The vesicular stomatitis virus G (VSVG) protein is a transmembran glycoprotein, which is involved in virus attachment to the specific receptor at the cell surface. This protein has been widely used to study therapeutic gene delivery. However,
Fereshteh Ghandehari, Mandana Behbahani, Abbasali Pourazar, Zahra Nourmohammadi   +3 more
doaj  

Oncolytic virotherapy induced CSDE1 neo-antigenesis restricts VSV replication but can be targeted by immunotherapy

Nature Communications, 2021
Oncolytic viruses, such as vesicular stomatitis virus (VSV), are a promising class of cancer therapeutics. Here the authors report that a mutation in the CSDE1 gene renders cancer cells resistant to VSV replication and oncolysis, but a mutation-derived ...
Timothy Kottke, Jason Tonne, Laura Evgin, Christopher B. Driscoll, Jacob van Vloten, Victoria A. Jennings, Amanda L. Huff, Brady Zell, Jill M. Thompson, Phonphimon Wongthida, Jose Pulido, Matthew R. Schuelke, Adel Samson, Peter Selby, Elizabeth Ilett, Mark McNiven, Lewis R. Roberts, Mitesh J. Borad, Hardev Pandha, Kevin Harrington, Alan Melcher, Richard G. Vile   +21 more
doaj   +1 more source

Queuing model of axonal transport [PDF]

arXiv, 2021
The motor-driven intracellular transport of vesicles to synaptic targets in the axons and dendrites of neurons plays a crucial role in normal cell function. Moreover, stimulus-dependent regulation of active transport is an important component of long-term synaptic plasticity, whereas the disruption of vesicular transport can lead to the onset of ...
arxiv  

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Postexposure Treatment of Marburg Virus Infection

Emerging Infectious Diseases, 2010
Rhesus monkeys are protected from disease when a recombinant vesicular stomatitis virus–based vaccine is administered 20–30 min after infection with Marburg virus.
Thomas W. Geisbert, Lisa E. Hensley, Joan B. Geisbert, Anders Leung, Joshua C. Johnson, Allen Grolla, Heinz Feldmann   +6 more
doaj   +1 more source

The Transport of Extrusive Volcanic Deposits on Jezero Crater Through Paleofluvial Processes [PDF]

Journal of the Washington Academy of Sciences, Volume 108, Summer 2022, 2022
Jezero, an impact crater in the Syrtis Major quadrangle of Mars, is generally thought to have amassed a large body of liquid water in its ancient past. NASA spectra of the proposed paleolake interpret the youngest surface unit as olivine-bearing minerals crystallized from magma.
arxiv  

Fusogenic Nanoreactor‐Based Detection of Extracellular Vesicle‐derived miRNAs for Diagnosing Atherosclerosis

Small, EarlyView.
This study introduces an all‐in‐one diagnostic system that amplifies target genes through interactions between serum EVs and fusogenic liposomes. Using padlock probes and enzymes within liposomes, the system enables miRNA amplification upon fusion. It successfully detects miR‐33a, miR‐126, and miR‐145, showing strong diagnostic performance comparable ...
Jiyoon Lee, Kiyoon Kwon, Min Ji Cho, Taesang Son, Yuna Roh, Sugi Lee, Dae‐Soo Kim, Moo‐Seung Lee, Hyun Seung Ban, Jang‐Seong Kim, Eun‐Kyung Lim, Sang‐Hak Lee, Goo Taeg Oh, Jong‐Gil Park, Tae‐Su Han   +14 more
wiley   +1 more source

Vesicularity, bubble formation and noble gas fractionation during MORB degassing [PDF]

Chemical Geology 343, 85 (2013), 2013
The objective of this study is to use molecular dynamics simulation (MD) to evaluate the vesicularity and noble gas fractionation, and to shed light on bubble formation during MORB degassing. A previous simulation study (Guillot and Sator (2011) GCA 75, 1829-1857) has shown that the solubility of CO2 in basaltic melts increases steadily with the ...
arxiv   +1 more source