Results 61 to 70 of about 1,140,792 (221)

From Interferon Signature to the Clinical Landscape: Type I Interferonopathies

Arthritis &Rheumatology, EarlyView.
Objective TypeI interferonopathies are heterogeneous diseases driven by dysregulated type I interferon (IFN‐I) signaling. Diagnosis is challenging due to clinical/molecular variability and the need for IFN‐I quantification. The aim of this study was to characterize the clinical, immunologic, genetic, molecular profiles of patients with suspected ...
Ismail Yaz, Seza Ozen, Hacer Neslihan Bildik, Canberk Ipsir, Dilara Unal, Saliha Esenboga, Begum Cicek, Mehmet Emin Seker, Fatima Aerts‐Kaya, Seher Sener, Mehmet Orhan Erkan, Hanife Avci, Deniz Cagdas, Ilhan Tezcan   +13 more
wiley   +1 more source

Quantification of Lyssavirus-Neutralizing Antibodies Using Vesicular Stomatitis Virus Pseudotype Particles [PDF]

, 2016
Rabies is a highly fatal zoonotic disease which is primarily caused by rabies virus (RABV) although other members of the genus Lyssavirus can cause rabies as well. As yet, 14 serologically and genetically diverse lyssaviruses have been identified, mostly
Zimmer, Gert, Karl-Klaus Conzelmann, Gert Zimmer, Samira Locher, Sarah Moeschler, Beate Krämer, Krämer, Beate, Moeschler, Sarah, Conzelmann, Karl-Klaus, Locher, Samira   +9 more
core   +2 more sources

Replication of Vesicular Stomatitis Virus in L Cells [PDF]

, 1970
Title: Replication of Vesicular Stomatitis Virus in L Cells, Author: Martin Petric, Location: ThodeA heat resistant strain (HR-LT) of the Indiana serotype of vesicular stomatitis virus was characterized.
Petric, Martin
core   +1 more source

Producing Vesicular Stomatitis Virus G (VSVG) Protein and Assessment of its Cytotoxic Activity against Breast Cancer Cells

مجله دانشکده پزشکی اصفهان, 2015
Background: The vesicular stomatitis virus G (VSVG) protein is a transmembran glycoprotein, which is involved in virus attachment to the specific receptor at the cell surface. This protein has been widely used to study therapeutic gene delivery. However,
Fereshteh Ghandehari, Mandana Behbahani, Abbasali Pourazar, Zahra Nourmohammadi   +3 more
doaj  

Re-engineering vesicular stomatitis virus to abrogate neurotoxicity, circumvent humoral immunity, and enhance oncolytic potency.

Cancer Research, 2014
As cancer treatment tools, oncolytic viruses (OV) have yet to realize what some see as their ultimate clinical potential. In this study, we have engineered a chimeric vesicular stomatitis virus (VSV) that is devoid of its natural neurotoxicity while ...
A. Muik, L. Stubbert, Roza Z. Jahedi, Yvonne Gei, J. Kimpel, Catherine Dold, R. Tober, A. Volk, S. Klein, U. Dietrich, Beta Yadollahi, T. Falls, H. Miletic, D. Stojdl, J. Bell, D. von Laer   +15 more
semanticscholar   +1 more source

High Cell Density Cultivation of HEK293 Cells Using a 2L Membrane‐Stirred Bioreactor

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The use of perfusion systems for the continuous cultivation of animal cells at high cell density (HCD) for the production of recombinant proteins, viruses, and viral vectors has many advantages. Besides an enhancement of volumetric productivity and high cell viability, the product quality can be improved through a steady‐state environment ...
Lennart Jacobtorweihe, Yasemin van Heuvel, Kathrina Scheiermann, Patrick Bongartz, Yvonne Genzel, Udo Reichl   +5 more
wiley   +1 more source

Oncolytic virotherapy induced CSDE1 neo-antigenesis restricts VSV replication but can be targeted by immunotherapy

Nature Communications, 2021
Oncolytic viruses, such as vesicular stomatitis virus (VSV), are a promising class of cancer therapeutics. Here the authors report that a mutation in the CSDE1 gene renders cancer cells resistant to VSV replication and oncolysis, but a mutation-derived ...
Timothy Kottke, Jason Tonne, Laura Evgin, Christopher B. Driscoll, Jacob van Vloten, Victoria A. Jennings, Amanda L. Huff, Brady Zell, Jill M. Thompson, Phonphimon Wongthida, Jose Pulido, Matthew R. Schuelke, Adel Samson, Peter Selby, Elizabeth Ilett, Mark McNiven, Lewis R. Roberts, Mitesh J. Borad, Hardev Pandha, Kevin Harrington, Alan Melcher, Richard G. Vile   +21 more
doaj   +1 more source

Durability of a Vesicular Stomatitis Virus-Based Marburg Virus Vaccine in Nonhuman Primates

PLoS ONE, 2014
The filoviruses, Marburg virus (MARV) and Ebola virus, causes severe hemorrhagic fever with high mortality in humans and nonhuman primates. A promising filovirus vaccine under development is based on a recombinant vesicular stomatitis virus (rVSV) that ...
C. Mire, J. Geisbert, K. Agans, Benjamin A. Satterfield, Krista M. Versteeg, Elizabeth A. Fritz, H. Feldmann, Lisa E. Hensley, T. Geisbert   +8 more
semanticscholar   +1 more source

Engineering Stable Lentiviral Vector Producer Cells Improves LVV Production

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Stable lentiviral vector producer cell lines represent a promising platform for scalable and cost‐efficient vector manufacturing, yet their productivity is often limited by intrinsic host‐cell constraints. In this study, we aimed to identify cellular factors restricting LVV production in stable doxycycline‐inducible GPRTG producer cell lines ...
Jona Röscheise, Lena‐Marie Eberle, Holger Laux, Kerstin Otte   +3 more
wiley   +1 more source

Comparison of antiviral activity of extracts from transgenic chicory, lactuca and marshmallow plants

Фактори експериментальної еволюції організмів, 2013
Aim. Comparison of antiviral activity effectiveness (suppression of vesicular stomatitis virus Indiana strain in bovine kidney cell line MDBK) by extracts from transgenic roots of lettuce, chicory and marshmallow with ifn-α2b gene was done. Methods. The
N. A. Matvieieva, Yu. I. Kudryavets, O. O. Lichova, O. Yu. Kvasko, A. M. Shachovsky   +4 more
doaj