Results 31 to 40 of about 1,140,792 (221)

A method for the generation of pseudovirus particles bearing SARS coronavirus spike protein in high yields

Cell Structure and Function, 2022
The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has threatened human health and the global economy. Development of additional vaccines and therapeutics is urgently required, but such development with live virus must be ...
Yoichiro Fujioka, Sayaka Kashiwagi, Aiko Yoshida, Aya O. Satoh, Mari Fujioka, Maho Amano, Yohei Yamauchi, Yusuke Ohba   +7 more
doaj   +1 more source

Atomic model of vesicular stomatitis virus and mechanism of assembly

Nature Communications, 2022
Zhou and Si et al. used cryogenic electron microscopy and tomography to delineate the molecular interactions among genomic RNA, nucleocapsid protein, matrix protein and glycoprotein in vesicular stomatitis virus and suggest a model of assembly.
Kang Zhou, Zhu Si, Peng Ge, Jun Tsao, Ming Luo, Z. Hong Zhou   +5 more
doaj   +1 more source

The vesicular stomatitis virus-based Ebola virus vaccine: From concept to clinical trials

Human Vaccines & Immunotherapeutics, 2018
The devastating Ebola virus (EBOV) epidemic in West Africa in 2013–2016 accelerated the progress of several vaccines and antivirals through clinical trials, including the replication-competent vesicular stomatitis virus-based vaccine expressing the EBOV ...
Ellen L. Suder, Wakako Furuyama, H. Feldmann, A. Marzi, E. de Wit   +4 more
semanticscholar   +1 more source

Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapy [PDF]

, 2009
Background: Glioblastoma is the most frequent and most malignant primary brain tumor with a poor prognosis. The translation of therapeutic strategies for glioblastoma from the experimental phase into the clinic has been limited by insufficient animal ...
Oleg Tsinkalovsky, Euskirchen Philipp, Tsanan Giroglou, Huszthy, Peter C., Giroglou Tsanan, Skaftnesmo, Kai Ove, Miletic, Hrvoje, Miletic Hrvoje, Peter C Huszthy, Kai Ove Skaftnesmo, Tsinkalovsky Oleg, von Laer Dorothee, Euskirchen, Philipp, Dorothee von Laer, Hrvoje Miletic, Laer, Dorothee von, Rolf Bjerkvig, Giroglou, Tsanan, Tsinkalovsky, Oleg, Huszthy Peter C., Skaftnesmo Kai Ove, Bjerkvig Rolf, Philipp Euskirchen, Bjerkvig, Rolf   +23 more
core   +2 more sources

Phase Transitions Drive the Formation of Vesicular Stomatitis Virus Replication Compartments

mBio, 2018
RNA viruses compartmentalize their replication machinery to evade detection by host pattern recognition receptors and concentrate the machinery of RNA synthesis.
Bianca S. Heinrich, Z. Maliga, D. A. Stein, A. Hyman, Sean P. J. Whelan   +4 more
semanticscholar   +1 more source

Helical Virus Structure: The Case of the Rhabdovirus Bullet

Viruses, 2010
Commentary on Ge, P.; Tsao, J.; Schein, S.; Green, T.J.; Luo, M.; Zhou, Z.H. Cryo-EM model of the bullet-shaped vesicular stomatitis virus. Science 2010, 327, 689-693.
Jay C. Brown, William W. Newcomb, Gail W. Wertz   +2 more
doaj   +1 more source

Oncolytic Vesicular Stomatitis Virus as a Viro-Immunotherapy: Defeating Cancer with a “Hammer” and “Anvil”

Biomedicines, 2017
Oncolytic viruses have gained much attention in recent years, due, not only to their ability to selectively replicate in and lyse tumor cells, but to their potential to stimulate antitumor immune responses directed against the tumor. Vesicular stomatitis
M. Melzer, A. López Martínez, J. Altomonte   +2 more
semanticscholar   +1 more source

Evaluating Temperature Sensitivity of Vesicular Stomatitis Virus–Based Vaccines

Emerging Infectious Diseases, 2019
Use of the vesicular stomatitis virus (VSV)–based Ebola virus vaccine during outbreaks and the potential use of a similar VSV-based Lassa virus vaccine has raised questions about the vaccines’ stability should the cold chain fail.
Derek R. Stein, Patrycja Sroga, Bryce M. Warner, Yvon Deschambault, Guillaume Poliquin, David Safronetz   +5 more
doaj   +1 more source

Preparation of Class Y Immunoglobulins that Neutralize the Marburg Virus

Проблемы особо опасных инфекций, 2021
The aim was to study the possibility of inducing Marburg-neutralizing chicken antibodies (MARV) using various immunogens.Materials and methods. Recombinant vaccinia virus expressing the surface glycoprotein (GP) transgene MARV of Musoke strain and ...
O. A. Polezhaeva, A. V. Zybkina, A. V. Zaikovskaya, O. V. P’yankov, S. A. P’yankov, A. V. Semenova, G. V. Semenova, D. N. Shcherbakov   +7 more
doaj   +1 more source

Oncotargeting by Vesicular Stomatitis Virus (VSV): Advances in Cancer Therapy

Viruses, 2018
Modern oncotherapy approaches are based on inducing controlled apoptosis in tumor cells. Although a number of apoptosis-induction approaches are available, site-specific delivery of therapeutic agents still remain the biggest hurdle in achieving the ...
S. Bishnoi, Ritudhwaj Tiwari, Sharad Gupta, S. Byrareddy, D. Nayak   +4 more
semanticscholar   +1 more source