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Vesicular Neurotransmitter Transporters: An Approach for Studying Transporters With Purified Proteins

Physiology, 2013
Vesicular storage and subsequent release of neurotransmitters are the key processes of chemical signal transmission. In this process, vesicular neurotransmitter transporters are responsible for loading the signaling molecules. The use of a “clean biochemical” approach with purified, recombinant transporters has helped in the identification of novel ...
Hiroshi, Omote, Yoshinori, Moriyama
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Role of WDR44 in vesicular protein transport

2023
Tesis (Doctorado en Ciencias Biológicas Mención Biología Celular y Molecular)--Pontificia Universidad Católica de Chile, 2021 ; El tráfico vesicular de proteínas en las rutas exocítica y endocítica define la composición de la membrana plasmática y es regulado por una maquinaria proteica donde las GTPasas de la familia Rab juegan un papel crucial.
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Regulation of vesicular transport by GTP-binding proteins

Current Opinion in Nephrology and Hypertension, 1995
Intracellular protein trafficking occurs in a series of transport vesicles. Vesicle trafficking is regulated both by heterotrimeric and monomeric GTP-binding proteins (G proteins). Recent studies have explored effector systems used by heterotrimeric G proteins and by monomeric ADP-ribosylation factor G proteins for regulation of vesicle budding.
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Transendothelial vesicular transport of protein in brain edema induced by ultraviolet irradiation

Acta Neuropathologica, 1977
Focal vasogenic brain edema was induced by ultraviolet irradiation of the exposed cerebral cortex of 16 cats. In 5 animals horseradish peroxidase was intravenously injected at times varying from 30 min to 24 h following irradiation and allowed to circulate for 45 min. Fixation was carried out by perfusion and immersion with glutaraldehyde.
S, Sasaki, R, Ferszt, J, Cervós-Navarro
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Immunochemical Analysis of Vesicular Monoamine Transporter (VMAT2) Protein in Parkinson's Disease

Experimental Neurology, 1999
The vesicular monoamine transporter (VMAT2) has been suggested to be an excellent marker of presynaptic dopaminergic nerve terminals in the striatum of Parkinson's disease patients based on its high level of expression and insensitivity to drugs used to treat the disease.
G W, Miller   +6 more
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Dopamine D2 receptor activation increases vesicular dopamine uptake and redistributes vesicular monoamine transporter-2 protein

European Journal of Pharmacology, 2004
Recent studies demonstrate that multiple dopamine receptor subtypes contribute to the regulation of vesicular monoamine transporter-2 (VMAT-2) activity. The present studies extend these findings by demonstrating that administration of the nonselective dopamine D2 receptor family agonist, quinpirole, rapidly increased vesicular dopamine uptake in ...
Jannine G, Truong   +3 more
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The roles of the human lipid-binding proteins ORP9S and ORP10S in vesicular transport

Biochemistry and Cell Biology, 2005
Inactivation of the yeast oxysterol binding protein related protein (ORP) family member Kes1p allows yeast cells to survive in the absence of Sec14p, a phospholipid transfer protein required for cell viability because of the role it plays in transporting vesicles from the Golgi.
Gregory D, Fairn   +1 more
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Protein Kinase A Affects Trafficking of the Vesicular Monoamine Transporters in PC12 Cells

Traffic, 2004
Previous studies have shown that the vesicular monoamine transporter 2 (VMAT2) is localized to both large dense core vesicles and synaptic vesicles in vivo. However, when exogenously expressed in PC12 cells, VMAT2 localizes only to large dense core vesicles. This distribution is similar to that of the endogenous vesicular monoamine transporter 1 (VMAT1)
Jia, Yao   +2 more
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The Autopalmitoylated Vesicular Transport Protein Bet3

2018
In eukaryotic cells the transport along secretory and endocytic pathways is performed by vesicular carriers. The initial attachment of a vesicle to the target membrane is called tethering. In case of ER-to-Golgi transport this step is performed by the TRAPP (transport protein particle) complex. The subunit Bet3 is present twice in the complex.
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Non-clathrin coat proteins in biosynthetic vesicular protein transport

1995
Biosynthetic vesicular protein transport defines a pathway from the cotranslational import of proteins into the endoplasmic reticulum (ER) via the Golgi apparatus to various cellular organelles or to the cell surface. During constitutive protein transport soluble luminal cargo proteins are secreted once their transport vesicles fuse with the plasma ...
C. L. Harter, F. T. Wieland
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