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Role of WDR44 in vesicular protein transport
2023Tesis (Doctorado en Ciencias Biológicas Mención Biología Celular y Molecular)--Pontificia Universidad Católica de Chile, 2021 ; El tráfico vesicular de proteínas en las rutas exocítica y endocítica define la composición de la membrana plasmática y es regulado por una maquinaria proteica donde las GTPasas de la familia Rab juegan un papel crucial.
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Small GTP-binding proteins in vesicular transport
Trends in Biochemical Sciences, 1990Recent recognition of the abundance of small GTP-binding proteins in eukaryotic cells has sparked off a search for the possible function of these proteins. Evidence is accumulating that SAR1, ARF, SEC4 and YPT1 in yeast and the rab and arf family in mammalian cells play a central role in the regulation of vesicle transport and organelle function.
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Immunochemical Analysis of Vesicular Monoamine Transporter (VMAT2) Protein in Parkinson's Disease
Experimental Neurology, 1999The vesicular monoamine transporter (VMAT2) has been suggested to be an excellent marker of presynaptic dopaminergic nerve terminals in the striatum of Parkinson's disease patients based on its high level of expression and insensitivity to drugs used to treat the disease.
G W, Miller +6 more
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Regulation of vesicular transport by GTP-binding proteins
Current Opinion in Nephrology and Hypertension, 1995Intracellular protein trafficking occurs in a series of transport vesicles. Vesicle trafficking is regulated both by heterotrimeric and monomeric GTP-binding proteins (G proteins). Recent studies have explored effector systems used by heterotrimeric G proteins and by monomeric ADP-ribosylation factor G proteins for regulation of vesicle budding.
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Non-clathrin coat proteins in biosynthetic vesicular protein transport
1995Biosynthetic vesicular protein transport defines a pathway from the cotranslational import of proteins into the endoplasmic reticulum (ER) via the Golgi apparatus to various cellular organelles or to the cell surface. During constitutive protein transport soluble luminal cargo proteins are secreted once their transport vesicles fuse with the plasma ...
C. L. Harter, F. T. Wieland
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The plant vesicular transport engineering for production of useful recombinant proteins
Journal of Molecular Catalysis B: Enzymatic, 2004Abstract The molecular breeding of plants that have been genetically engineered for improved disease resistance and stress tolerance has been undertaken with the goal of improving food production. More recently, it has been realized that transgenic plants can serve as bioreactors for the production of proteins or compounds with industrial or clinical
Kazuya Yoshida +2 more
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Transendothelial vesicular transport of protein in brain edema induced by ultraviolet irradiation
Acta Neuropathologica, 1977Focal vasogenic brain edema was induced by ultraviolet irradiation of the exposed cerebral cortex of 16 cats. In 5 animals horseradish peroxidase was intravenously injected at times varying from 30 min to 24 h following irradiation and allowed to circulate for 45 min. Fixation was carried out by perfusion and immersion with glutaraldehyde.
S, Sasaki, R, Ferszt, J, Cervós-Navarro
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Small G Proteins: Arf Family GTPases in Vesicular Transport
2014Small GTP-binding proteins of the ADP-ribosylation factor (Arf) family are key components of trafficking vesicles. In the past three decades a number of vesicular carriers, whose formation depends on members of the Arf family were identified, and general molecular mechanisms how these transport carriers form and operate were established.
Frank Adolf, Felix T. Wieland
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Loss of Striatal Vesicular Monoamine Transporter Protein (VMAT2) in Human Cocaine Users
American Journal of Psychiatry, 2003The hypothesis that human cocaine users lose vesicular monoamine transporter (VMAT2) protein was tested in striatal samples from cocaine users and age-, sex-, and postmortem interval-matched comparison subjects.Striatal samples were retrieved at autopsy; immunoblot assays were then performed by using a highly specific VMAT2 antibody.
Karley Y, Little +3 more
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G Protein Regulation of Vesicular Transport Through the Exocytic Pathway
1993A central problem in cell biology is to understand the molecular basis for the transport of itinerant soluble and membrane-associated macromolecules through multiple compartments of the exocytic and endocytic pathways of eukaryotic cells. Transport involves a multiplicity of components which facilitate the formation of coat protein complexes leading to
W. E. Balch +7 more
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