Results 51 to 60 of about 241,468 (251)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

High-quality genome assembly and annotation of live animal vaccine bacteria strains in South Korea

BMC Genomic Data
Objectives Selecting and managing suitable seed strains according to standard principles is a critical factor in manufacturing high-quality biological products.
Yeonkyeong Lee, Jin-Ju Nah, Hyun-Ok Ku, Il Jang   +3 more
doaj   +1 more source

Ivermectin - old drug, new tricks? [PDF]

, 2017
Ivermectin is one of the most important drugs in veterinary and human medicine for the control of parasitic infection and was the joint focus of the 2015 Nobel Prize in Physiology or Medicine, some 35 years after its remarkable discovery.
Devaney, Eileen, Gillan, Victoria, Laing, Roz   +2 more
core   +1 more source

Applying an Ethical Lens to the Treatment of People With Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The practice of neurology requires an understanding of clinical ethics for decision‐making. In multiple sclerosis (MS) care, there are a wide range of ethical considerations that may arise. These involve shared decision‐making around selection of a disease‐modifying therapy (DMT), risks and benefits of well‐studied medications in comparison to
Methma Udawatta, Farrah J. Mateen
wiley   +1 more source

Metagenomic analysis of gut microbiota diversity in poultry before and after antibiotic administration

Ветеринария сегодня
The diversity of gut microbiota is an important ecological resource that plays a key role in maintenance of the host homeostasis. It is extremely important to preserve the existing gut microbiota diversity, which ensures its resistance to the negative ...
O. V. Prasolova, N. I. Malik, I. A. Timofeeva, N. A. Kirsanova, E. V. Krylova, E. V. Malik, I. A. Rusanov, N. A. Chupakhina   +7 more
doaj   +1 more source

INFLUENCE OF ANTIMICROBIAL DRUG USE IN POULTRY BREEDING ON MEAT SAFETY

Archives of Veterinary Medicine, 2010
Recognition of food safety problems brings into focus the importance of primary production. Overuse of antimicrobial drugs in animal breeding is reality it is only a question in what manner and extent it influences on food safety.
Jelena Petrović, Dubravka Milanov, Miloš Kapetanov   +2 more
doaj   +1 more source

Electroactive Metal–Organic Frameworks for Electrocatalysis

Advanced Functional Materials, EarlyView.
Electrocatalysis is crucial in sustainable energy conversion as it enables efficient chemical transformations. The review discusses how metal–organic frameworks can revolutionize this field by offering tailorable structures and active site tunability, enabling efficient and selective electrocatalytic processes.
Irena Senkovska, Yutong Luo, Ruyan Zhao, Jianjun Zhang, Mingchao Wang, Xinliang Feng, Eike Brunner, Stefan Kaskel   +7 more
wiley   +1 more source

Permeation of Indomethacin through Skin Using Nanonized Alaptide

ADMET and DMPK, 2015
Alaptide, (S)-8-methyl-6,9-diazaspiro[4.5]decan-7,10-dione, is an original Czech compound; in this paper it is used as an excipient. The investigation deals with the affection of the permeation of indomethacin through full-thickness pig ear skin using a ...
Aneta Cernikova, Jiri Dohnal, Josef Jampilek   +2 more
doaj   +1 more source

Frequency and Severity of Neutropenia Associated with Food and Drug Administration Approved and Compounded Formulations of Lomustine in Dogs with Cancer. [PDF]

, 2015
BackgroundCompounded lomustine is used commonly in veterinary patients. However, the potential variability in these formulations is unknown and concern exists that compounded formulations of drugs may differ in potency from Food and Drug Administration ...
Burton, JH, Knych, HK, Rebhun, RB, Rodriguez, CO, Skorupski, KA, Stanley, SD   +5 more
core   +2 more sources

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source