Results 71 to 80 of about 2,175 (163)

Image_2_Redundancy and Specificity of Type VI Secretion vgrG Loci in Antibacterial Activity of Agrobacterium tumefaciens 1D1609 Strain.TIF

, 2020
Type VI secretion system (T6SS) is a contractile nanoweapon employed by many Proteobacteria to deliver effectors to kill or inhibit their competitors.
Shu-Ting Cho (811674), Chih-Feng Wu (117145), Mary Nia M. Santos (8294598), Chun-Ju Chang (184639), Erh-Min Lai (117152), Chih-Horng Kuo (63286)   +5 more
core   +1 more source

Pathogenic Potential of Invasive Mucosa‐Associated Klebsiella pneumoniae Isolates in Ulcerative Colitis: Characterization of Virulence Factors and Inflammatory Response

Immunity, Inflammation and Disease, Volume 13, Issue 10, October 2025.
This study was conducted in 83 patients with ulcerative colitis (UC). Klebsiella pneumoniae isolates showed a higher prevalence of virulence genes (fimH, hcp, fyuA, irp1) compared to non‐UC controls. UC isolates exhibited increased adhesion (29% vs. 8%) and invasion (16% vs.
Ensieh Olamafar, Abbas Yadegar, Shabnam Shahrokh, Maryam Tajabadi Ebrahimi, Hamidreza Houri   +4 more
wiley   +1 more source

The Type VI Secretion TssEFGK-VgrG Phage-Like Baseplate Is Recruited to the TssJLM Membrane Complex via Multiple Contacts and Serves As Assembly Platform for Tail Tube/Sheath Polymerization.

PLoS Genetics, 2015
The Type VI secretion system (T6SS) is a widespread weapon dedicated to the delivery of toxin proteins into eukaryotic and prokaryotic cells. The 13 T6SS subunits assemble a cytoplasmic contractile structure anchored to the cell envelope by a membrane ...
Yannick R Brunet, Abdelrahim Zoued, Frédéric Boyer, Badreddine Douzi, Eric Cascales   +4 more
doaj   +1 more source

The Road Less Traveled: Exploring the Genomic Characteristics and Antimicrobial Resistance Potential of Acinetobacter baumannii From the Indigenous Orang Asli Community in Peninsular Malaysia

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
Analysis of Acinetobacter baumannii from healthy individuals in a rural Malaysian community revealed significant genetic diversity, including novel sequence types. These isolates carry resistance genes and resemble clinical strains, highlighting their potential to cause disease despite their commensal origin.
Soo‐Sum Lean, Denise E. Morris, Rebecca Anderson, Ahmed Ghazi Alattraqchi, David W. Cleary, Stuart C. Clarke, Chew Chieng Yeo   +6 more
wiley   +1 more source

Genomic Analysis and Virulence Features of Vibrio cholerae Non‐O1/Non‐O139 Harbouring CARB‐Type β‐Lactamases From Freshwater Bodies, Argentina

Environmental Microbiology Reports, Volume 17, Issue 5, October 2025.
Genomic analysis of ampicillin‐resistant Vibrio cholerae non‐O1/non‐O139 from central Argentina's freshwater bodies identified four novel CARB‐β‐lactamase variants linked to the V. cholerae superintegron. An unusual VPI‐1 arrangement encoding the TCP pilus and a type VI secretion system subclass i5 was also found, associated with increased ...
Daiana Guevara Núñez, Fabrizzio N. Morandini, Geehan Suleyman, Kyle Crooker, Jagjeet Kaur, Gina Maki, José L. Bocco, Darío Fernández Do Porto, Markus J. Zervos, Claudia Sola, H. Alex Saka   +10 more
wiley   +1 more source

Comparative Genomics of Aeromonas hydrophila Secretion Systems and Mutational Analysis of hcp1 and vgrG1 Genes From T6SS

Frontiers in Microbiology, 2019
Virulent Aeromonas hydrophila causes severe motile Aeromonas septicemia in warmwater fishes. In recent years, channel catfish farming in the U.S.A. and carp farming in China have been affected by virulent A.
Hasan C. Tekedar, Hossam Abdelhamed, Salih Kumru, Jochen Blom, Attila Karsi, Mark L. Lawrence   +5 more
doaj   +1 more source

Mechanistic insights into the T6SS of multi‐drug‐resistant Aeromonas hydrophila and its role in competition and pathogenesis

mLife, Volume 4, Issue 4, Page 363-377, August 2025.
Abstract Aeromonas hydrophila, an opportunistic pathogen, often encodes Type VI Secretion System (T6SS) genes. However, the specific functions of T6SS, particularly in the context of clinical strains, remain poorly understood. In this study, we characterize a multi‐drug‐resistant strain, AH54, which possesses a complete and functional T6SS, composed of
Hao Wang, Ying Liu, Zhao Wang, PeiYi Xia, Zhiwei Li, Ming Liu, Yang Fu   +6 more
wiley   +1 more source

Two cysteines control Tse1 secretion by H1‐T6SS in Pseudomonas aeruginosa

Protein Science, Volume 34, Issue 8, August 2025.
Abstract Type Six Secretion Systems (T6SS) are molecular machines that export toxic effector proteins into bacterial competitors or eukaryotic cells. Pseudomonas aeruginosa's H1‐T6SS secretes Tse1, which contains a disulfide bond between cysteines at positions 7 and 148, linking its N‐ and C‐terminal regions.
Marie M. Grandjean, Jean‐Pierre Duneau, Edwige B. Garcin, Laetitia Houot, Olivier Bornet, Christophe Bordi, Latifa Elantak, Corinne Sebban‐Kreuzer   +7 more
wiley   +1 more source

The gp27-like Hub of VgrG Serves as Adaptor to Promote Hcp Tube Assembly

, 2018
International audienceContractile injection systems are multiprotein complexes that use a spring-like mechanism to deliver effectors into target cells. In addition to using a conserved mechanism, these complexes share a common core known as the tail. The
Journet, Laure, Douzi, Badreddine, Renault, Melvin, G, Cambillau, Christian, Cascales, E., Brunet, Yannick, R, Chabalier, Maïalène, Zoued, Abdelrahim, Zamarreño Beas, Jordi   +8 more
core   +1 more source

Type 6 secretion system components hcp and vgrG support mutualistic partnership between Xenorhabdus bovienii symbiont and Steinernema jollieti host

, 2023
Xenorhabdus, like other Gram-negative bacteria, possesses a Type 6 Secretion System (T6SS) which acts as a contact-dependent molecular syringe, delivering diverse proteins (effectors) directly into other cells.
Min-Woo Lee, Patricia, Stock, S., Lee, M.-W., Ratnasri Pothula, Pothula, R., S. Patricia Stock   +5 more
core   +1 more source