Results 81 to 90 of about 2,175 (163)

A Dual‐Targeting T6SS DNase Drives Bacterial Antagonism and Eukaryotic Apoptosis via the cGAS‐STING‐TNF Axis

Advanced Science, Volume 12, Issue 28, July 24, 2025.
The bacterial Type VI secretion system (T6SS) emerges as a sophisticated virulence mechanism, leveraging the dual‐function effector TkeA from Yersinia pseudotuberculosis. TkeA concurrently damages rival bacteria and host cell DNA, triggering the host's cGAS‐STING‐TNF pathway and inducing apoptosis.
Li Song, Lei Xu, Pengfei Zhang, Shuying Li, Yichen Qu, Yixin Zhao, Zhenkun Shi, Ruiqi Ma, Yongdong Li, Yi Chen, Yao Wang, Zhengfan Jiang, Gehong Wei, Xihui Shen   +13 more
wiley   +1 more source

Cyanophage Infections in a Sponge Intracellular Cyanobacterial Symbiont

Environmental Microbiology, Volume 27, Issue 7, July 2025.
Intracellular cyanobacterial symbionts of sponges are shown to be susceptible to cyanophages, challenging assumptions about their isolation from viral exposure. The study reveals novel phage–host interactions and suggests conserved infection strategies across symbionts of marine and terrestrial animals.
Tzipora Peretz, Esther Cattan‐Tsaushu, Chiara Conti, Benyamin Rosental, Laura Steindler, Sarit Avrani   +5 more
wiley   +1 more source

The Type VI Secretion System of Sinorhizobium fredii USDA257 Is Required for Successful Nodulation With Glycine max cv Pekin

Microbial Biotechnology, Volume 18, Issue 3, March 2025.
The functional type VI secretion system of Sinorhizobium fredii USDA257 is required for successful nodulation with Glycine max cv Pekin. ABSTRACT The symbiotic relationship between rhizobia and legumes is critical for sustainable agriculture and has important economic and environmental implications.
Pedro José Reyes‐Pérez, Irene Jiménez‐Guerrero, Ana Sánchez‐Reina, Cristina Civantos, Natalia Moreno‐de Castro, Francisco Javier Ollero, Jacinto Gandullo, Patricia Bernal, Francisco Pérez‐Montaño   +8 more
wiley   +1 more source

A widespread accessory protein family diversifies the effector repertoire of the type VI secretion system spike

Nature Communications
Type VI secretion systems (T6SSs) are macromolecular assemblies that deliver toxic effector proteins between adjacent bacteria. These effectors span a wide range of protein families that all lack canonical signal sequences that would target them for ...
Jake Colautti, Huagang Tan, Nathan P. Bullen, Stephanie S. Thang, Dirk Hackenberger, Andrew C. Doxey, John C. Whitney   +6 more
doaj   +1 more source

The Role of Type VI Secretion System Effectors in Target Cell Lysis and Subsequent Horizontal Gene Transfer

Cell Reports, 2017
Bacteria use type VI secretion systems (T6SSs) to manipulate host cells during pathogenesis or to kill competing bacteria, which, in some cases, increases horizontal gene transfer.
Peter David Ringel, Di Hu, Marek Basler
doaj   +1 more source

Molecular Epidemiology and Antimicrobial Resistance of Klebsiella pneumoniae Strains Isolated From Dairy Cows in Xinjiang, China

Veterinary Medicine and Science, Volume 11, Issue 1, January 2025.
WGS identified 27 wzi allele types (2 new), 16 K antigen serotypes, 6 O antigen serotypes, 25 sequence types (3 new), 39 antibiotic resistance and 57 virulence genes in Klebsiella pneumoniae from milk samples of cows with and without mastitis. Phylogenetic analysis showed high genomic diversity in K. pneumoniae.
Kuojun Cai, Min Xu, Lu Liu, Hongqiong Zhao   +3 more
wiley   +1 more source

Type VI secretion: a beginner's guide [PDF]

, 2008
Type VI secretion is a newly described mechanism for protein transport across the cell envelope of Gram-negative bacteria. Components that have been partially characterised include an IcmF homologue, the ATPase ClpV, a regulatory FHA domain protein and ...
Bailey, Christopher, Bailey, Christopher M., Bingle, Lewis E. H., Bailey, Christopher M, Pallen, Mark J, Pallen, Mark J., Bingle, Lewis, Pallen, Mark   +7 more
core   +1 more source

An Overview of Anti-Eukaryotic T6SS Effectors

Frontiers in Cellular and Infection Microbiology, 2020
The type VI secretion system (T6SS) is a transmembrane multiprotein nanomachine employed by many Gram-negative bacterial species to translocate, in a contact-dependent manner, effector proteins into adjacent prokaryotic or eukaryotic cells.
Julia Monjarás Feria, Miguel A. Valvano
doaj   +1 more source

VgrG-Bla_TEM-1 fusions can be secreted into the supernatant.

, 2020
Top panels: the gene encoding BlaTEM-1 (orange) was fused to (A) vgrG1a and (B) vgrG4b, while each downstream region on the chromosome was left unaltered.
Sarah Wettstadt (7107035), Alain Filloux (190708)   +1 more
core   +1 more source

A combination of genomics and transcriptomics provides insights into the distribution and differential mRNA expression of type VI secretion system in clinical Klebsiella pneumoniae

mSphere
The type VI secretion system (T6SS) serves as a crucial molecular weapon in interbacterial competition and significantly influences the adaptability of bacteria in their ecological niche.
Wanzhen Li, Xiaolan Huang, Dan Li, Xiaofen Liu, Xiaoying Jiang, Xingchen Bian, Xin Li, Jing Zhang   +7 more
doaj   +1 more source