Results 141 to 150 of about 509,068 (300)

International learning communities for global and localcitizenship

European Journal for Research on the Education and Learning of Adults, 2011
In this paper, I describe our ongoing international project in engaged educationalethnography and participatory action research with young adults and consider itsrelevance for a discussion on the community-building role of adult education in aglobalized ...
Hana Cervinkova
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Hatchery Salmon and Ecological Overshoot

Aquaculture, Fish and Fisheries
Is there an ecological niche for ‘ocean ranched’ hatchery salmon, Oncorhynchus spp., to supplement wild salmon? Ecologically, I hypothesize that the carrying capacity for biota is: (1) limited; (2) filled with locally adapted biota competing and ...
Benjamin William Van Alen
doaj   +1 more source

Crossroads Rhode Island: Proposed Social Enterprise Business Plan [PDF]

, 2014
Crossroads Rhode Island provides their clients with a continuum of care that includes basic emergency needs, shelter, housing, case management and vocational services for individuals and families.
Brookes, Joe, Cooper, Joel, Fernandez, Victoria, Lake, Darci, Robinson, Arnold, Rosenfield, Matt   +5 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Gluteus Maximus-Tensor Fascia Lata Transfer With Double-Row Repair and Bioinductive Scaffold Augmentation for Chronic Abductor Tendon Tears

Arthroscopy Techniques
Hip abductor tendon tears are a common cause of lateral hip pain and gait disturbance, especially in older adults. While conservative treatment is first-line, high failure rates often necessitate surgical intervention.
Jorge Sánchez-Mateos, M.D., Felipe Casanova, M.D., M. Agustina Olaran, M.D., Juan Bernardo Villarreal-Espinosa, M.D., Melissa L. Carpenter, B.S., Germán Escribano, M.D., Jorge Chahla, M.D., Ph.D.   +6 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Promoting the empowerment and emancipation of community-dwelling older adults with chronic multimorbidity through a home visiting programme: a hermeneutical study

BMC Nursing
Introduction Nurse-led preventive home visiting programmes can improve health-related outcomes in community-dwelling older adults, but they have not proven to be cost-effective.
Iria Dobarrio-Sanz, Anabel Chica-Pérez, Olga María López-Entrambasaguas, José Manuel Martínez-Linares, José Granero-Molina, José Manuel Hernández-Padilla   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source