Results 11 to 20 of about 5,053,828 (347)

Canonical and Divergent N-Terminal HBx Isoform Proteins Unveiled: Characteristics and Roles during HBV Replication

Biomedicines, 2021
Hepatitis B virus (HBV) X protein (HBx) is a viral regulatory and multifunctional protein. It is well-known that the canonical HBx reading frame bears two phylogenetically conserved internal in-frame translational initiation codons at Met2 and Met3, thus
Sergio Hernández, Francisca Álvarez-Astudillo, Daniel Garrido, Cristian Prieto, Alejandra Loyola, Rodrigo A. Villanueva   +5 more
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The demethylase inhibitor GSK-J4 limits inflammatory colitis by promoting de novo synthesis of retinoic acid in dendritic cells

Scientific Reports, 2021
Dendritic cells (DCs) promote T-cell mediated tolerance to self-antigens and induce inflammation to innocuous-antigens. This dual potential makes DCs fundamental players in inflammatory disorders.
Cristian Doñas, Jocelyn Neira, Francisco Osorio-Barrios, Macarena Carrasco, Dominique Fernández, Carolina Prado, Alejandra Loyola, Rodrigo Pacheco, Mario Rosemblatt   +8 more
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Pre- and Post-Transcriptional Control of HBV Gene Expression: The Road Traveled towards the New Paradigm of HBx, Its Isoforms, and Their Diverse Functions

Biomedicines, 2023
Hepatitis B virus (HBV) is an enveloped DNA human virus belonging to the Hepadnaviridae family. Perhaps its main distinguishable characteristic is the replication of its genome through a reverse transcription process. The HBV circular genome encodes only
Rodrigo A. Villanueva, Alejandra Loyola
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A Large-Scale Genome-Based Survey of Acidophilic Bacteria Suggests That Genome Streamlining Is an Adaption for Life at Low pH

Frontiers in Microbiology, 2022
The genome streamlining theory suggests that reduction of microbial genome size optimizes energy utilization in stressful environments. Although this hypothesis has been explored in several cases of low-nutrient (oligotrophic) and high-temperature ...
Diego Cortez, Gonzalo Neira, Carolina González, Eva Vergara, David S. Holmes, David S. Holmes   +5 more
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Dopaminergic stimulation leads B-cell infiltration into the central nervous system upon autoimmunity

Journal of Neuroinflammation, 2021
Background Recent evidence has shown dopamine as a major regulator of inflammation. Accordingly, dopaminergic regulation of immune cells plays an important role in the physiopathology of inflammatory disorders.
Carolina Prado, Francisco Osorio-Barrios, Paulina Falcón, Alexandra Espinoza, Juan José Saez, María Isabel Yuseff, Rodrigo Pacheco   +6 more
doaj   +1 more source

Nanosecond pulsed electric field (nsPEF) and vaccines: a novel technique for the inactivation of SARS-CoV-2 and other viruses?

Annals of Medicine, 2022
Since the beginning of 2020, worldwide attention has been focused on SARS-CoV-2, the second strain of the severe acute respiratory syndrome virus.
A. R. Ruiz-Fernández, M. Rosemblatt, T. Perez-Acle   +2 more
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Correlação entre uso de álcool e drogas e o risco de suicídio em pessoas diagnosticadas com transtorno afetivo bipolar: uma visão geral

Debates em Psiquiatria, 2023
Introdução: O transtorno afetivo bipolar (TAB) é uma condição psiquiátrica complexa, caracterizada por alterações extremas de humor, incluindo episódios de mania e depressão. A relação entre o uso de álcool, drogas e o risco de suicídio em pacientes com
Stéfanie Venturini Fanton, Marilene Ferraz Cavalieri, Carla Tereza Ruiz Cerqueira, Lucas Pilla Garcia, Marcela Bezerra Zanusso, Carolina Capelasso de Oliveira   +5 more
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Draft genome sequence of the type strain of the sulfur-oxidizing acidophile, Acidithiobacillus albertensis (DSM 14366)

Standards in Genomic Sciences, 2017
Acidithiobacillus albertensis is an extremely acidophilic, mesophilic, obligatory autotrophic sulfur-oxidizer, with potential importance in the bioleaching of sulfidic metal ores, first described in the 1980s. Here we present the draft genome sequence of
Matías Castro, Ana Moya-Beltrán, Paulo C. Covarrubias, Mónica Gonzalez, Juan Pablo Cardenas, Francisco Issotta, Harold Nuñez, Lillian G. Acuña, Gonzalo Encina, David S. Holmes, D. Barrie Johnson, Raquel Quatrini   +11 more
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Antisense noncoding mitochondrial RNA-2 gives rise to miR-4485-3p by Dicer processing in vitro

Biological Research, 2021
Background The antisense noncoding mitochondrial RNAs (ASncmtRNAs) derive from the mitochondrial 16S gene. Knockdown of these transcripts with chemically-modified antisense oligonucleotides induces proliferative arrest, apoptosis and invasiveness ...
Nicole Farfán, Nicole Sanhueza, Macarena Briones, Luis O. Burzio, Verónica A. Burzio   +4 more
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Pasado presente y futuro de la estimulación ovárica en el tratamiento de la infertilidad

Revista Médica Clínica Las Condes, 2021
Resumen: La mejor comprensión de la fisiología reproductiva y la disponibilidad de más y mejores recursos diagnóstico/terapéuticos permiten individualizar la estimulación ovárica y hacerla más efectiva (mejores resultados), eficiente (en menos tiempo y ...
Efraín Pérez-Peña, Ernesto Pérez-Luna, Kahiry Ledezma, Antonio Gutiérrez-Gutiérrez   +3 more
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