Results 11 to 20 of about 15,406 (277)
Neurological Research and Practice, 2022 Background Nearly one in three unconscious cardiac arrest survivors experience post-anoxic status epilepticus (PASE). Historically, PASE has been deemed untreatable resulting in its exclusion from status epilepticus clinical trials.
Carolina B. Maciel +11 more
doaj +2 more sources
Gain-of-function GABRB3 variants identified in vigabatrin-hypersensitive epileptic encephalopathies [PDF]
Brain Communications, 2020 Variants in the GABRB3 gene encoding the β3-subunit of the γ-aminobutyric acid type A ( receptor are associated with various developmental and epileptic encephalopathies.
N. Absalom +20 more
semanticscholar +2 more sources
Acquired parvalbumin‐selective interneuronopathy in the multiple‐hit model of infantile spasms: A putative basis for the partial responsiveness to vigabatrin analogs? [PDF]
Epilepsia Open, 2018 West syndrome, an age‐specific epileptic encephalopathy, manifests with infantile spasms (IS) and impaired neurodevelopmental outcomes and epilepsy. The multiple‐hit rat model of IS is a chronic model of IS due to structural etiology, in which spasms ...
Anna-Maria Katsarou +4 more
semanticscholar +2 more sources
Vigabatrin retinal toxicity in children with infantile spasms [PDF]
Neurology, 2014 Objectives: To determine time to vigabatrin (VGB, Sabril; Lundbeck, Deerfield, IL) induced retinal damage in children with infantile spasms (IS) and to identify risk factors for VGB-induced retinal damage (VGB-RD).
C. Westall +6 more
semanticscholar +2 more sources
Towards a Synthesis of Vigabatrin Using Glycal Chemistry [PDF]
Molecules, 2005 Application of the Ferrier rearrangement led to a novel carbohydrate based synthetic route to 4-aminohexenoic acid viz. (R) and (S)-vigabatrin. The potential of D- glucose or D-galactose as the chiral starting materials for the synthesis of (R) and (S ...
I. Aidhen, J. Aidhen, S. Boga
doaj +2 more sources
Vigabatrin and high-dose prednisolone therapy for patients with West syndrome
Epilepsy Research, 2018 A. Ko +6 more
semanticscholar +3 more sources
Vigabatrin and Tiagabine Might have Antipanic Properties [PDF]
, 2004 Rupprecht, Rainer, Zwanzger, P.
core +2 more sources
Annals of Neurology, 2023 This study was undertaken to test the hypothesis that early vigabatrin treatment in tuberous sclerosis complex (TSC) infants improves neurocognitive outcome at 24 months of age.
E. Bebin +20 more
semanticscholar +1 more source
Epilepsia, 2023 This study was undertaken to evaluate our treatment algorithm for infantile epileptic spasms syndrome (IESS) used between 2000 and 2018.
M. Kuchenbuch +4 more
semanticscholar +1 more source
Response to sequential treatment with prednisolone and vigabatrin in infantile spasms
Journal of Paediatrics and Child Health, 2022 To report response to first treatment in infants with infantile spasms (IS), including incremental benefit of prednisolone 60 mg/day and vigabatrin following prednisolone 40 mg/day failure in infants commenced on the United Kingdom Infantile Spasms Study
W. Dzau +6 more
semanticscholar +1 more source