Results 11 to 20 of about 14,898 (265)
Combination Therapy With Vigabatrin and Prednisolone Versus Vigabatrin Alone for Infantile Spasms [PDF]
Annals of Clinical and Translational NeurologyABSTRACTObjectiveThe study evaluated the effectiveness of combination therapy with vigabatrin and prednisolone versus vigabatrin alone for treating infantile epileptic spasms syndrome (IESS).MethodsThis single‐center, single‐blind, randomized trial enrolled infants aged 2–14 months with new‐onset IESS, randomly assigned them (1:1) to receive either ...
Rachata Boonkrongsak +6 more
openaire +4 more sources
Dried Blood Spot Analysis for Simultaneous Quantification of Antiepileptic Drugs Using Liquid Chromatography–Tandem Mass Spectrometry [PDF]
Rapid Communications in Mass Spectrometry, Volume 39, Issue 16, 30 August 2025.ABSTRACT Rationale Dried blood spot (DBS) sampling for the therapeutic drug monitoring of antiepileptic drugs offers practical advantages, including minimal invasiveness and ease of collection. However, for precise therapeutic management, its accuracy and reliability in quantification need to be validated.
Mariam M. Abady +2 more
wiley +2 more sources
Annals of Neurology, 2023 This study was undertaken to test the hypothesis that early vigabatrin treatment in tuberous sclerosis complex (TSC) infants improves neurocognitive outcome at 24 months of age.
E. Bebin +20 more
semanticscholar +1 more source
Epilepsia, 2023 This study was undertaken to evaluate our treatment algorithm for infantile epileptic spasms syndrome (IESS) used between 2000 and 2018.
M. Kuchenbuch +4 more
semanticscholar +1 more source
Response to sequential treatment with prednisolone and vigabatrin in infantile spasms
Journal of Paediatrics and Child Health, 2022 To report response to first treatment in infants with infantile spasms (IS), including incremental benefit of prednisolone 60 mg/day and vigabatrin following prednisolone 40 mg/day failure in infants commenced on the United Kingdom Infantile Spasms Study
Winston Dzau +6 more
semanticscholar +1 more source
Developmental Medicine and Child Neurology, 2001 The new antiepileptic drugs introduced over the last decade provide a welcome increase in the therapeutic options available for the 25% of children with epilepsy who remain refractory to traditional therapy.1 In the mid 1980s, vigabatrin (VGB) was the first of these to be made available in clinical practice.
Hilary Lewis Mb BCh Mrcp Mrcpch and +1 more
openaire +3 more sources
Vigabatrin-associated Reversible MRI Abnormalities in an Infant with Tuberous Sclerosis.
Journal of Radiology Case Reports, 2021 Vigabatrin therapy is commonly used in infants diagnosed with tuberous sclerosis complex, particularly in the setting of epilepsy. Utilization of vigabatrin can result in bilateral and symmetric abnormal sequence changes within the deep brain matter and ...
Joseph Franklin Craft, A. Cardenas
semanticscholar +1 more source
Neurotherapeutics, 2007 Refractory epilepsies such as infantile spasms (IS) and complex partial seizures (CPS) can have a severe negative impact on the neurological integrity and quality of life of affected patients, in addition to drastically increasing their risk of premature mortality.
James W, Wheless +2 more
openaire +2 more sources
Treatment with High-Dose Prednisolone in Vigabatrin-Refractory Infantile Spasms
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2021 : Objectives: This research aimed to study the short-term seizure outcomes following treatment with 8 mg/kg/day prednisolone in children with infantile spasms (IS) refractory to vigabatrin.
Wafaa Al-Shehhi +7 more
semanticscholar +1 more source