Results 21 to 30 of about 7,079 (166)

Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain [PDF]

Arquivos de Neuro-Psiquiatria, 1999
Since anticonvulsants have been used for treating neuralgias, an interest has arisen to experimentally test vigabatrin for its gabaergic mechanism of action.
NILZA D. ALVES, CARLOS M. DE CASTRO-COSTA, ALBA M. DE CARVALHO, FRANKLIN J. C. SANTOS, DELANO G. SILVEIRA   +4 more
doaj   +1 more source

Infantile Epileptic Spasms Syndrome Complicating Mosaic Down-Turner Syndrome: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Severe baseline developmental delays in complex genetic syndromes like Down‐Turner mosaicism can completely mask the psychomotor regression of Infantile Epileptic Spasms Syndrome (IESS). Clinicians must maintain a high index of suspicion and prioritize early video‐EEG screening for any abnormal paroxysmal movements.
Shahrori M, Nofal K, Alkhawaja HH, Mohsen W, Alzamari AA.   +4 more
europepmc   +2 more sources

Vigabatrin induced Cell loss in the Cerebellar Cortex of Albino Rats [PDF]

Journal of Clinical and Diagnostic Research, 2013
Background: Vigabatrin is used as the drug of choice in resistant epilepsy and infantile spasms. Ataxia, tremors and abnormal gait have been frequently reported following the use of this drug, indicating an involvement of the cerebellum.
Deepa Singh, Sunder Lal Jethani, Aksh Dubey   +2 more
doaj   +1 more source

Clinical profile of vigabatrin as monotherapy for treatment of infantile spasms [PDF]

, 2010
Jason T Lerner1, Noriko Salamon2, Raman Sankar1,31Departments of Pediatrics, 2Radiological Sciences, 3Neurology, David Geffen School of Medicine, University of California Los Angeles and Mattel Children’s Hospital at UCLA, Los Angeles, CA ...
Salamon, Noriko, null Lerner, null Salamon, Raman Sankar, Jason T Lerner, Lerner, Jason T, Noriko Salamon, Sankar, Raman   +7 more
core   +1 more source

Perturbação psicótica aguda associada à vigabatrina.

Acta Médica Portuguesa, 2000
Vigabatrin, a drug mainly used in the treatment of therapy-resistant epilepsy, has been associated to a large range of adverse effects, including acute psychotic disorders. The authors report the case of a 44-year-old patient with drug-resistant temporal
M Xavier, M S Bento, D P Pereira, J M De Almeida   +3 more
doaj   +1 more source

Clinical profile and treatment of infantile spasms using vigabatrin and ACTH - a developing country perspective

BMC Pediatrics, 2010
Background Infantile spasms represent a serious epileptic syndrome that occurs in the early infantile age. ACTH and Vigabatrin are actively investigated drugs in its treatment.
Ishaque Sidra, Gulab Shamshad, Ibrahim Shahnaz, Saleem Taimur   +3 more
doaj   +1 more source

Vigabatrin as add-on therapy for adult complex partial seizures: a double-blind, placebo-controlled multicentre study [PDF]

, 2000
Vigabatrin (VGB) is a novel antiepileptic drug effective as adjunctive therapy in patients with partial seizures. In this study, the efficacy and tolerability of VGB as adjunctive therapy were evaluated in patients with refractory epilepsy.
A. Guberman, Desforges, C., Vachon, L., Guberman, A., THE CANADIAN VIGABATRIN STUDY GROUP,, L. Vachon, null THE CANADIAN VIGABATRIN STUDY GROUP, Bruni, J., J. Bruni, C. Desforges   +9 more
core   +1 more source

Vigabatrin-induced retinal toxicity is partially mediated by signaling in rod and cone photoreceptors. [PDF]

PLoS ONE, 2012
Vigabatrin (VGB) is a commonly prescribed antiepileptic drug designed to inhibit GABA-transaminase, effectively halting seizures. Unfortunately, VGB treatment is also associated with the highest frequencies of peripheral visual field constriction of any ...
Jin Yang, Matthew C Naumann, Yi-Ting Tsai, Joaquin Tosi, Deniz Erol, Chyuan-Sheng Lin, Richard J Davis, Stephen H Tsang   +7 more
doaj   +1 more source

Vigabatrin for focal drug delivery in epilepsy: Bilateral microinfusion into the subthalamic nucleus is more effective than intranigral or systemic administration in a rat seizure model

Neurobiology of Disease, 2012
Vigabatrin is a rationally developed antiepileptic drug, which acts by increasing GABA levels in the brain by irreversibly inhibiting GABA degradation.
Sonja Bröer, Bianca Backofen-Wehrhahn, Marion Bankstahl, Laura Gey, Manuela Gernert, Wolfgang Löscher   +5 more
doaj   +1 more source

Déficits visuels associés au vigabatrin: étude de patients argentins [PDF]

, 2014
Objective: The aim of the present study was to assess visual alterations in a population of Argentine patients treated with the antiepileptic drug vigabatrin.
Giagante, Brenda, Benozzi, Jorge, Rosenstein, Ruth Estela, Kochen, Sara Silvia, Moreno, María Cecilia, Saidon, Patricia Claudia   +5 more
core   +1 more source