Results 31 to 40 of about 10,435 (208)

Vigabatrin for focal drug delivery in epilepsy: Bilateral microinfusion into the subthalamic nucleus is more effective than intranigral or systemic administration in a rat seizure model

Neurobiology of Disease, 2012
Vigabatrin is a rationally developed antiepileptic drug, which acts by increasing GABA levels in the brain by irreversibly inhibiting GABA degradation.
Sonja Bröer, Bianca Backofen-Wehrhahn, Marion Bankstahl, Laura Gey, Manuela Gernert, Wolfgang Löscher   +5 more
doaj   +1 more source

Epileptic spasms - 175 years on: Trying to teach an old dog new tricks [PDF]

, 2017
PURPOSE: This text provides an overview of how the condition "infantile spasms" has evolved in the last 175 years. METHOD: Key references are summarised to assimilate this review.
Ibekwe, RC, O'Callaghan, FJK, Wilmshurst, JM   +2 more
core   +1 more source

Does the Swedish Interactive Threshold Algorithm (SITA) accurately map visual field loss attributed to vigabatrin? [PDF]

, 2014
Purpose Vigabatrin (VGB) is an anti-epileptic medication which has been linked to peripheral constriction of the visual field. Documenting the natural history associated with continued VGB exposure is important when making decisions about the risk and
Conway, M. L., Cubbidge, P. R., Hosking, L. S., Zhu, H.   +3 more
core   +3 more sources

Safety and Efficacy of Vigabatrin for the Treatment of Infantile Spasms

Journal of Central Nervous System Disease, 2011
In 2009, vigabatrin became the first FDA approved medication for the treatment of infantile spasms in the United States. There are few well-designed prospective studies comparing the drug to placebo or other modalities used in the treatment of infantile ...
Michele A. Faulkner, Justin A. Tolman
doaj   +1 more source

Scotopic threshold response changes after vigabatrin therapy in a child without visual field defects: a new electroretinographic marker of early damage?

Neurobiology of Disease, 2004
Vigabatrin (VGB) has been widely used in patients affected by drug-resistant epilepsy and West syndrome. Following reports of visual field loss associated with vigabatrin therapy, some authors have investigated retinal electrophysiologic variables to ...
Pasquale Parisi, Paolo Tommasini, Giuseppe Piazza, Mario Manfredi   +3 more
doaj   +1 more source

Visual evoked potentials in succinate semialdehyde dehydrogenase (SSADH) deficiency [PDF]

, 2009
In mammals, increased GABA in the central nervous system has been associated with abnormalities of visual evoked potentials (VEPs), predominantly manifested as increased latency of the major positive component P100.
Blasi, P, Crutchfield, SR, Di Rosa, G, Dionisi-Vici, C, Gibson, KM, Malaspina, P, Rizzo, C, Tortorella, G   +7 more
core   +1 more source

Intravitreal triamcinolone acetonide as an adjunct in the treatment of severe ocular toxoplasmosis [PDF]

, 2006
Universidade Federal de São Paulo, Vis Inst, São Paulo, BrazilUniversidade Federal de São Paulo, Vis Inst, São Paulo, BrazilWeb of ...
C Muccioli, F B Aggio, JB Jonas, JM Benitez Del Castillo Sanchez, K Kishore, R Belfort, RB Nussenblatt   +6 more
core   +1 more source

Epilepsy, Antiepileptic Drugs, and Aggression: An Evidence-Based Review. [PDF]

, 2016
Antiepileptic drugs (AEDs) have many benefits but also many side effects, including aggression, agitation, and irritability, in some patients with epilepsy.
Alan B. Ettinger, Albert P. Aldenkamp, Bernhard J. Steinhoff, Besag, Biton, Brodkin, Brown, Carmichael, Chiaretti, Coccaro, Cánovas Martínez, David R. Sibley, Delgado-Escueta, Devinsky, Dolton, D’Souza, Edwards, Elliott, Ettinger, Feindel, Flor-Henry, Frank Besag, Friedman, Gabriella Gobbi, Gedye, Gobbi, Gollan, Hemming, Huband, Jan, Kang, Klüver, Krishnamoorthy, Kugaya, Lander, Landolt, Lee, LoPresti, Loup, Maletzky, Maletzky, Marco Mula, Martin J. Brodie, Mpakopoulou, Mula, Olsen, Pandya, Ratner, Raucci, Robinson, Ruuskanen, Schmitz, Seidenwurm, Shehata, Silver, Stefano Comai, Steinhoff, Szczurowska, Turski, Van Paesschen, Wieshmann   +60 more
core   +3 more sources

Clinical Pharmacology & Therapeutics: Past, Present, and Future. [PDF]

, 2017
Clinical Pharmacology & Therapeutics (CPT), the definitive and timely source for advances in human therapeutics, transcends the drug discovery, development, regulation, and utilization continuum to catalyze, evolve, and disseminate discipline ...
Terzic, Andre, Waldman, Scott A.
core   +2 more sources

Vigabatrin-Induced Visual Field Defects

Pediatric Neurology Briefs, 1998
A drug surveillance database at Hoechst Marion Roussel, manufacturers of vigabatrin, identified 92 cases of symptomatic visual field defects associated with vigabatrin (usually as add-on therapy) between 1990 and 1997.
J Gordon Millichap
doaj   +1 more source