Results 11 to 20 of about 10,435 (208)
Peripheral visual field defect of vigabatrin in pediatric epilepsy: A review
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2023 Vigabatrin is the medication used for the treatment of infantile spasms and refractory complex partial seizures, but its usage has always been contradictory due to its effect on vision.
Umme Habeeba A. Pathan +3 more
doaj +1 more source
Neurological Research and Practice, 2022 Background Nearly one in three unconscious cardiac arrest survivors experience post-anoxic status epilepticus (PASE). Historically, PASE has been deemed untreatable resulting in its exclusion from status epilepticus clinical trials.
Carolina B. Maciel +11 more
doaj +1 more source
Developmental Medicine and Child Neurology, 2001 The new antiepileptic drugs introduced over the last decade provide a welcome increase in the therapeutic options available for the 25% of children with epilepsy who remain refractory to traditional therapy.1 In the mid 1980s, vigabatrin (VGB) was the first of these to be made available in clinical practice.
H, Lewis, S J, Wallace
openaire +2 more sources
Bi-allelic GAD1 variants cause a neonatal onset syndromic developmental and epileptic encephalopathy. [PDF]
, 2020 Developmental and epileptic encephalopathies are a heterogeneous group of early-onset epilepsy syndromes dramatically impairing neurodevelopment. Modern genomic technologies have revealed a number of monogenic origins and opened the door to therapeutic ...
Alix, E +30 more
core +2 more sources
Vigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complex. [PDF]
PLoS ONE, 2013 Epilepsy is a common neurological disorder and cause of significant morbidity and mortality. Although antiseizure medication is the first-line treatment for epilepsy, currently available medications are ineffective in a significant percentage of patients
Bo Zhang +3 more
doaj +1 more source
Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain [PDF]
Arquivos de Neuro-Psiquiatria, 1999 Since anticonvulsants have been used for treating neuralgias, an interest has arisen to experimentally test vigabatrin for its gabaergic mechanism of action.
NILZA D. ALVES +4 more
doaj +1 more source
Optimal management of seizures associated with tuberous sclerosis complex: current and emerging options. [PDF]
, 2014 Seizures are clinically significant manifestations associated with 79%-90% of patients with tuberous sclerosis complex. Often occurring within the first year of life in the form of infantile spasms, seizures interfere with neuropsychiatric, social, and ...
Fallah, Aria, Wang, Shelly
core +2 more sources
On-Off Intermittency in Time Series of Spontaneous Paroxysmal Activity in Rats with Genetic Absence Epilepsy [PDF]
, 2006 Dynamic behavior of complex neuronal ensembles is a topic comprising a streamline of current researches worldwide. In this article we study the behavior manifested by epileptic brain, in the case of spontaneous non-convulsive paroxysmal activity.
Alexander Hramov +10 more
core +3 more sources
Vigabatrin induced Cell loss in the Cerebellar Cortex of Albino Rats [PDF]
Journal of Clinical and Diagnostic Research, 2013 Background: Vigabatrin is used as the drug of choice in resistant epilepsy and infantile spasms. Ataxia, tremors and abnormal gait have been frequently reported following the use of this drug, indicating an involvement of the cerebellum.
Deepa Singh +2 more
doaj +1 more source
Emerging pharmacotherapy of tinnitus [PDF]
, 2009 Tinnitus, the perception of sound in the absence of an auditory stimulus, is perceived by about 1 in 10 adults, and for at least 1 in 100, tinnitus severely affects their quality of life.
Ana Belén Elgoyhen +43 more
core +1 more source