Results 21 to 30 of about 15,406 (277)
Neurotherapeutics, 2007 Refractory epilepsies such as infantile spasms (IS) and complex partial seizures (CPS) can have a severe negative impact on the neurological integrity and quality of life of affected patients, in addition to drastically increasing their risk of premature mortality.
James W, Wheless +2 more
openaire +2 more sources
Treatment with High-Dose Prednisolone in Vigabatrin-Refractory Infantile Spasms
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2021 : Objectives: This research aimed to study the short-term seizure outcomes following treatment with 8 mg/kg/day prednisolone in children with infantile spasms (IS) refractory to vigabatrin.
Wafaa Al-Shehhi +7 more
semanticscholar +1 more source
Peripheral visual field defect of vigabatrin in pediatric epilepsy: A review
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2023 Vigabatrin is the medication used for the treatment of infantile spasms and refractory complex partial seizures, but its usage has always been contradictory due to its effect on vision.
Umme Habeeba A. Pathan +3 more
doaj +1 more source
EVALUATION OF THE STABILITY OF VIGABATRIN IN HOSPITALAR EXTEMPORANEOUS FORMULATIONS
Drug Analytical Research, 2019 The aim of this study was to analyze the chemical stability of the anticonvulsant vigabatrin extemporaneous formulation from tablets in storage conditions of different temperatures and types of packaging used.
Marcio Vinicius Ayres +4 more
doaj +9 more sources
Developmental Medicine and Child Neurology, 2001 The new antiepileptic drugs introduced over the last decade provide a welcome increase in the therapeutic options available for the 25% of children with epilepsy who remain refractory to traditional therapy.1 In the mid 1980s, vigabatrin (VGB) was the first of these to be made available in clinical practice.
H, Lewis, S J, Wallace
openaire +2 more sources
Bi-allelic GAD1 variants cause a neonatal onset syndromic developmental and epileptic encephalopathy. [PDF]
, 2020 Developmental and epileptic encephalopathies are a heterogeneous group of early-onset epilepsy syndromes dramatically impairing neurodevelopment. Modern genomic technologies have revealed a number of monogenic origins and opened the door to therapeutic ...
Alix, E +30 more
core +2 more sources
Vigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complex. [PDF]
PLoS ONE, 2013 Epilepsy is a common neurological disorder and cause of significant morbidity and mortality. Although antiseizure medication is the first-line treatment for epilepsy, currently available medications are ineffective in a significant percentage of patients
Bo Zhang +3 more
doaj +1 more source
Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain [PDF]
Arquivos de Neuro-Psiquiatria, 1999 Since anticonvulsants have been used for treating neuralgias, an interest has arisen to experimentally test vigabatrin for its gabaergic mechanism of action.
NILZA D. ALVES +4 more
doaj +1 more source
Optimal management of seizures associated with tuberous sclerosis complex: current and emerging options. [PDF]
, 2014 Seizures are clinically significant manifestations associated with 79%-90% of patients with tuberous sclerosis complex. Often occurring within the first year of life in the form of infantile spasms, seizures interfere with neuropsychiatric, social, and ...
Fallah, Aria, Wang, Shelly
core +2 more sources