Results 21 to 30 of about 15,083 (304)
Peripheral visual field defect of vigabatrin in pediatric epilepsy: A review
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2023 Vigabatrin is the medication used for the treatment of infantile spasms and refractory complex partial seizures, but its usage has always been contradictory due to its effect on vision.
Umme Habeeba A. Pathan +3 more
doaj +1 more source
Neurotherapeutics, 2007 Refractory epilepsies such as infantile spasms (IS) and complex partial seizures (CPS) can have a severe negative impact on the neurological integrity and quality of life of affected patients, in addition to drastically increasing their risk of premature mortality.
James W, Wheless +2 more
openaire +2 more sources
Neurological Research and Practice, 2022 Background Nearly one in three unconscious cardiac arrest survivors experience post-anoxic status epilepticus (PASE). Historically, PASE has been deemed untreatable resulting in its exclusion from status epilepticus clinical trials.
Carolina B. Maciel +11 more
doaj +1 more source
Bi-allelic GAD1 variants cause a neonatal onset syndromic developmental and epileptic encephalopathy. [PDF]
, 2020 Developmental and epileptic encephalopathies are a heterogeneous group of early-onset epilepsy syndromes dramatically impairing neurodevelopment. Modern genomic technologies have revealed a number of monogenic origins and opened the door to therapeutic ...
Alix, E +30 more
core +2 more sources
Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain [PDF]
Arquivos de Neuro-Psiquiatria, 1999 Since anticonvulsants have been used for treating neuralgias, an interest has arisen to experimentally test vigabatrin for its gabaergic mechanism of action.
NILZA D. ALVES +4 more
doaj +1 more source
Optimal management of seizures associated with tuberous sclerosis complex: current and emerging options. [PDF]
, 2014 Seizures are clinically significant manifestations associated with 79%-90% of patients with tuberous sclerosis complex. Often occurring within the first year of life in the form of infantile spasms, seizures interfere with neuropsychiatric, social, and ...
Fallah, Aria, Wang, Shelly
core +2 more sources
Gain-of-function GABRB3 variants identified in vigabatrin-hypersensitive epileptic encephalopathies
Brain Communications, 2020 Variants in the GABRB3 gene encoding the β3-subunit of the γ-aminobutyric acid type A ( receptor are associated with various developmental and epileptic encephalopathies.
N. Absalom +20 more
semanticscholar +1 more source
Modulation of the GABAergic pathway for the treatment of fragile X syndrome. [PDF]
, 2014 Fragile X syndrome (FXS) is the most common genetic cause of intellectual disability and the most common single-gene cause of autism. It is caused by mutations on the fragile X mental retardation gene (FMR1) and lack of fragile X mental retardation ...
Hagerman, Randi J +2 more
core +1 more source
Epilepsia, 1999 Summary:Vigabatrin (VGB) is a structural analogue of the inhibitory neurotransmitter γ‐amino butyric acid (GABA), which produces its antiepileptic effect by irreversibly inhibiting the degradative enzyme GABA‐transaminase. This produces an increase in central nervous system (CNS) GABA levels.
openaire +3 more sources
Vigabatrin and depression. [PDF]
Journal of Neurology, Neurosurgery & Psychiatry, 1993 Ten patients who developed a major depressive episode in association with vigabatrin treatment for intractable epilepsy are reported. The depression usually occurred early in the course of treatment, but when delayed followed a recent increase in dose. Depressive symptoms occurred at doses varying between 1.5 g and 4 g a day, often but not always when ...
E. H. Reynolds +3 more
openaire +3 more sources