Results 121 to 130 of about 150,547 (296)

BcII RFLP for the human vimentin gene

Nucleic Acids Research, 1988
A 1.1 kb cDNA clone (hp4F1) encoding the human vimentin gene was identified in a human library by screening with 4F1, a hamster vimentin cDNA. BcII (TGATCA) recognizes a two allele polymorphism: bands A1 at 8.1 kb, and A2 at 3.6 kb. The allele frequency was determined in 47 unrelated Caucasian individuals. The RFLP was mapped to chromosome 10pter-10q23
MARCUS, EM, SMITH, BA, TELENIUS, H, LANDSVATER, RM, BUYS, CHCM, FERRARI, S, PONDER, BAJ, MATHEW, CGP   +7 more
openaire   +4 more sources

Role of Vimentin in Cancer Progression

Vimentin, a type III intermediate filament protein, is found in mesenchymal cells along with microfilaments and microtubules. It mainly functions to give structural support and viscoelastic resilience to the cells; in addition, it is also involved in ...
Usman, S
core   +3 more sources

TRIM28‐Derived Peptide Exerts Anti‐Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers

Advanced Science, EarlyView.
An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei, Changning Xue, Mengna Li, Jianxia Wei, Lemei Zheng, Shipeng Chen, Yijie Wang, Yumei Duan, Yanwei Luo, Wei Xiong, Ming Zhou   +10 more
wiley   +1 more source

Vimentin and tumor diagnosis

Chinese Journal of Cancer Research, 1991
Vimentin was isolated and purified from the pig eye lens by homogenization, ultracentrifugation, extraction in urea buffer and preparative eletrophoresis. It was identified with SDS-PAGE and rabbit anti-vimentin was raised against the purified vimentin.
Zhang Nong, Zhang Yuee, Chen Zhongnian, Zhang Xiurong, Li Maoshen   +4 more
openaire   +1 more source

Serum anti-modified citrullinated vimentin antibody concentration is associated with liver fibrosis in patients with chronic hepatitis

, 2011
Suad Abdeen, Samuel O Olusi, Sunila GeorgeDepartment of Pathology, Faculty of Medicine, Kuwait University, Safat, KuwaitBackground and aims: The hepatic stellate cell, which plays a pivotal role in hepatic fibrosis, contains the filament vimentin which ...
Samuel O Olusi, Suad Abdeen, Sunila George   +2 more
core  

Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

Advanced Science, EarlyView.
Single‐cell, spatial, molecular, and pathology analyses identify a CDH3‐associated malignant epithelial state in thymic epithelial tumors. This state links stem‐like and EMT programs to M2 macrophage–rich immunosuppressive niches, genomic instability, poor survival, and drug vulnerability.
Yuntao Feng, Jingyu Chen, Lang Xia, Tao Wang, Yuzhou Wang, Lei Zhang, Guofang Zhao, Long Xu, Juemin Yu, Yunlang She, Junqi Wu, Yue Zhao, Chang Chen, Deping Zhao   +13 more
wiley   +1 more source

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

Vimentin 3 and endothelin in prostate cancer.

, 2018
349 Background: An upregulation of vimentin 3, a truncated version of the full length vimentin, with an unknown function, was previously described by our group, in a direct dependency of increased ET-1 levels.
Melanie von Brandenstein, David Pfister, Tobias Kohl, Monika Schlosser, Jochen Fries, Andreas Stog, Axel Heidenreich, Timur H. Kuru   +7 more
core   +1 more source

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

Immunofluorescence analysis of vimentin expression.

, 2013
miR-125b-mimics, inhibitor and NC were transfected into MDA-MB-231 and MCF-7/ADR, respectively. Green, vimentin was immunostained with anti-vimentin; blue, nuclei were stained with DAPI.
Meijuan Zou (320750), Yunmian He (320748), Le Guo (320752), Rui Zhang (13940), Tao Xi (141120), Feng Tang (136667)   +5 more
core   +1 more source