Results 101 to 110 of about 142,715 (302)

Stromal‐Derived IL‐8 Promotes M2 Macrophage Polarization via the RhoA/MRTF‐A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer

Advanced Science, EarlyView.
In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu, Qiyu Fang, Jia Yu, Ting Yu, Huashan Shi, Kaiqi Jin, Lei Jiang, Wentian Zhang   +7 more
wiley   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Vimentin regulates mitochondrial ROS production and inflammatory responses of neutrophils

Frontiers in Immunology
The intermediate filament vimentin is present in immune cells and is implicated in proinflammatory immune responses. Whether and how it supports antimicrobial activities of neutrophils are not well established.
Thao Ngoc Huynh, Jody Toperzer, Allison Scherer, Allison Scherer, Anne Gumina, Tonya Brunetti, Michael K. Mansour, Michael K. Mansour, David M. Markovitz, Brian C. Russo   +9 more
doaj   +1 more source

Vimentin Phosphorylation Is Required for Normal Cell Division of Immature Astrocytes

Cells, 2019
Vimentin (VIM) is an intermediate filament (nanofilament) protein expressed in multiple cell types, including astrocytes. Mice with VIM mutations of serine sites phosphorylated during mitosis (VIMSA/SA) show cytokinetic failure in fibroblasts and lens ...
Yolanda de Pablo, Pavel Marasek, Andrea Pozo-Rodrigálvarez, Ulrika Wilhelmsson, Masaki Inagaki, Marcela Pekna, Milos Pekny   +6 more
doaj   +1 more source

Interaction of Vimentin With Actin and Phospholipids

The Biological Bulletin, 1998
Vimentin intermediate filaments are a major cytoskeletal constituent of cells of mesenchymal origin. They have been colocalized with a variety of intracellular structures such as actin filaments and the plasma membrane. Labeled actin filaments, observed in vitro by fluorescence microscopy, break in the presence of polymerizing vimentin; the time course
Shah, J V, Wang, Louise Z., Traub, Peter, Janmey, P A   +3 more
openaire   +4 more sources

Genome‐Wide In Vivo RNAi Screening Identifies HOXD4 as a Tumor Metastasis Suppressor in Colorectal Cancer

Advanced Science, EarlyView.
Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye, Wen‐jing Luo, Lu Li, Wen‐di Shuai, Ling Zhou, You‐fa Duan, Xue Chen, Jun‐kai Zhang, Wenlin Huang, Ran‐yi Liu   +9 more
wiley   +1 more source

Small Extracellular Vesicles‐Derived Circ6718 Unlocks Stromal Remodeling and Serves as a Biomarker in Gastric Cancer

Advanced Science, EarlyView.
sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang, Xueyan Zang, Dongli Wang, Rong Li, Hui Qian, Wenrong Xu, Jiajia Jiang, Yongmin Yan   +7 more
wiley   +1 more source

Structure and function of vimentin in the generation and secretion of extracellular vimentin in response to inflammation

Cell Communication and Signaling
Abstract The canonical functions of vimentin in cell mechanics and migration have been recently expanded by the discovery of new roles for extracellular vimentin (ECV) in immune responses to infection, injury and cancer. In contrast with the predominantly filamentous form of intracellular vimentin, ECV exists largely as soluble oligomers. The
Zhiyao Yuan, Paul A. Janmey, Christopher A. McCulloch   +2 more
openaire   +3 more sources

Developmentally Inspired Bioprinting of Nascent Multicellular Human Heart Tissue Through in Situ Differentiation and Morphogenesis of iPSCs

Advanced Science, EarlyView.
A developmentally inspired bioprinting approach enables the fabrication of pluripotent tissues that undergo shape‐morphing and in situ cardiac lineage specification. This method employs embedded bioprinting to deposit iPSCs within soft granular hydrogels to create pluripotent tissue constructs that undergo cell‐mediated shape morphogenesis.
Ankita Pramanick, Juhi Chakraborty, Orlaith Kennedy, Hey Wei Wong, Sogol Kianersi, Daniel Kelly, Vasileios Sergis, Abhay Pandit, Andrew C. Daly   +8 more
wiley   +1 more source

Immunostaining with anti-cytokeratin and anti-vimentin. [PDF]

, 2013
Immunostaining with anti-cytokeratin (panels A through D), anti-vimentin (panels E through H) and merge (panels I through L) are given. A, E, I, Parental cells show high levels of cytokeratin and little vimentin staining. Transfection with WT Bves (B, F,
Min S. Chang (46795), Tatsuki Koyama (46794), Michiya Kawaguchi (46791), Aya Wada (46793), Hillary A. Hager (46792), David M. Bader (46796)   +5 more
core   +1 more source