Results 91 to 100 of about 142,715 (302)

An Atypical Case of Pancreatic Cancer with Mesenchymal Differentiation in a Patient with Primary Lung Adenocarcinoma: Insights into Tumor Biology and Novel Therapeutic Pathways

Diagnostics
Background: Pancreatic cancer is among the malignancies with the poorest prognosis, largely due to its aggressive nature and resistance to conventional therapies.
Noura Abbas, Lama Zahreddine, Ayman Tawil, Mustafa Natout, Ali Shamseddine   +4 more
doaj   +1 more source

A Novel Perfused Full‐Thickness Human Skin Microphysiological System for Modeling Injury, Regeneration, Tumor Pathophysiology, and Therapeutics Development

Advanced Healthcare Materials, EarlyView.
What if human skin could remain fully alive and functional outside the body for weeks? A New Alternative Method (NAM) based on a vascularized full‐thickness skin microphysiological system achieves precisely this, preserving native vasculature, resident immunity, and metabolic activity for up to three weeks, while faithfully recapitulating radiation ...
Yusuf Surucu, Hamid Malekzadeh, Alexa Rivera Del Rio Hernandez, Naresh Mahajan, Ethan Banks, Dayyan Ur Rahman, José A. Arellano, Katherine S. Yang, Alexey Altman, G.V. Naveen Kumar, Matthew L. Steinhauser, Jeffrey A. Gusenoff, J. Peter Rubin, Asim Ejaz   +13 more
wiley   +1 more source

Vimentin and pathogen infection mechanism [PDF]

, 2023
La vimentine une protéine du filament intermédiaire exprimée dans différents types cellulaires, joue un rôle clé dans de multiples événements cellulaires. Dans ce travail, nous nous sommes concentrés sur la caractérisation des rôles que joue la vimentine
Arrindell, Jeffrey
core  

Dynamic Mechanical Loading Modulates Extracellular Vesicle Production and Cargo in Meniscus Fibrochondrocytes

Advanced Materials Interfaces, EarlyView.
Dynamic mechanical loading of outer meniscus fibrochondrocytes increases extracellular vesicle (EV) yield and alters EV composition. When applied to progenitor cells, these mechanically primed EVs modulate the expression of matrix‐related genes.
Catherine Cheung, Zizhao Li, Sung‐Han Jo, Se‐Hwan Lee, Il Keun Kwon, Jina Ko, Su Chin Heo   +6 more
wiley   +1 more source

From FIC to BID : target identification and functional characterization of "Bartonella" effector proteins [PDF]

, 2014
Pathogens belonging to the genus Bartonella employ a unique stealth infection strategy that involves evasion from the host immune system, replication in the endothelium and persistence in erythrocytes.
Pieles, Kathrin
core   +1 more source

Maskless Fabrication of PLA‐Based Neural Arrays for CNS Recording and Stimulation

Advanced Materials Interfaces, EarlyView.
Biodegradable neural interfaces enable bidirectional communication with the CNS. Through electrochemical characterization, ageing tests with impedance monitoring, and in vivo validation, we assess the performance of PLA‐based epicortical and spinal implants.
Anna De Salvo, Federica Velluto, Ilenia Sergi, Michele Di Lauro, Verónica Barranco‐Maresca, Elena Alonso‐Calviño, Yasmina Hernández‐Martín, Juan Aguilar, Juliana M. Rosa, María C. Serrano, Carolina Giulia Ferroni, Federico Rondelli, Elisa López‐Dolado, Luciano Fadiga, Fabio Biscarini   +14 more
wiley   +1 more source

3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress

Advanced Materials Technologies, EarlyView.
Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi, Ashley Vazquez, Alexander J. Choi, Dimitrios Karamichos, Jayoung Kim   +4 more
wiley   +1 more source

Identification of the most suitable in vitro model to study vimentin-G4 repeats interactions in epithelial-mesenchymal transition [PDF]

embargoed_20271022Vimentin (VIM) is an important intermediate filament protein that plays a key role in epithelial-mesenchymal transition (EMT), a process critical for cancer progression and metastasis.
SHAH, SYEDA ALVEENA
core  

The garlic compound ajoene covalently binds vimentin, disrupts the vimentin network and exerts anti-metastatic activity in cancer cells [PDF]

, 2019
CITATION: Kaschula, C. H., et al. 2019. The garlic compound ajoene covalently binds vimentin, disrupts the vimentin network and exerts anti-metastatic activity in cancer cells.
Hunter, Roger, Daniel A. Kusza, Katz, Arieh A., M. Iqbal Parker, Graham, Lisa M., Schafer, Georgia, Rafudeen, Mohamed S, Kaschula, Catherine H., Ngarande, Ellen, Rosanna Tuveri, Lisa M. Graham, Kusza, Daniel A, Kaschula, Catherine H, Parker, M. Iqbal, Tuveri, Rosanna, Barnett, Christopher, Arieh A. Katz, Graham, Lisa M, Mohamed Suhail Rafudeen, Roger Hunter, Ellen Ngarande, Catherine H. Kaschula, Kevin Dzobo, Christopher Barnett, Dzobo, Kevin, Georgia Schäfer, Kusza, Daniel A., Parker, M Iqba, Katz, Arieh A, Rafudeen, Mohamed Suhail   +29 more
core   +1 more source

Undervalued ubiquitous proteins

4 open, 2019
The role of ubiquitous proteins (UPs) and their corresponding enzymes have been underestimated in carcinogenesis as the focus of much research revolved around measuring mutations and/or other genetic epiphenomena as surrogate markers of cancer and cancer
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source