Results 111 to 120 of about 150,547 (296)

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

Advanced Science, EarlyView.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu, Xiang‐Nan Xu, Xiao Huang, Zhou Luo, Chun‐Lian Li, Yang Du, Cheng Yan, Xiao‐Jie Yu, Jian‐Wen Wang, Long‐Di Yao, De‐Yuan Fu   +10 more
wiley   +1 more source

Vimentin protects differentiating stem cells from stress

, 2023
Vimentin is one of the first cytoplasmic intermediate filaments to be expressed in mammalian cells during embryogenesis, but its role in cellular fitness has long been a mystery.
Kaganovich, Daniel, Meshorer, Eran; The Edmond and Lily Safra Center for Brain Research (ELSC), The Hebrew University of Jerusalem, Jerusalem, Israel, Azad, Gajendra Kumar; Department of Zoology, Patna University, Patna, India, Pattabiraman, Sundararaghavan; Department of Experimental Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany, Azad, Gajendra Kumar, Sze, Siu Kwan, Brielle, Shlomi, Brielle, Shlomi; Department of Experimental Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany, Sze, Siu Kwan; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore, Kaganovich, Daniel; Base Pharmaceuticals, Boston, USA, Meshorer, Eran, Amen, Triana, Park, Jung Eun, Park, Jung Eun; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore, Pattabiraman, Sundararaghavan, Amen, Triana; Department of Experimental Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany   +15 more
core   +1 more source

From Flow to Function: Using Different Static Mixers to Fabricate Microarchitected Materials Via Chaotic Printing

Advanced Science, EarlyView.
Complex microarchitectures emerge from simple flow‐driven transformations as static mixers iteratively reorient and split material domains. Coupled with diverse deposition strategies, chaotic printing provides an accessible platform for fabricating architected materials that support biologically and chemically relevant processes. ABSTRACT Nature builds
Edna Johana Bolívar‐Monsalve, Carlos Fernando Ceballos‐González, Diego Alonso Quevedo‐Moreno, Irving Isaí Rendón‐Moreno, Ariel Cantoral‐Sánchez, Héctor Ambriz‐González, Mario Moisés Alvarez, Grissel Trujillo‐de Santiago   +7 more
wiley   +1 more source

Type-III interferons and rheumatoid arthritis: Correlation between interferon lambda 1 (interleukin 29) and antimutated citrullinated vimentin antibody levels

Autoimmunity, 2017
Aim: To assess serum type III or lambda (λ) interferons (IFN) levels and its clinical and laboratory associations in rheumatoid arthritis (RA). Methods: A cross-sectional study including 43 patients with RA (86% females; age 45.3 ± 10.3 years) and 43 ...
Diana Castillo-Martínez, Maribel Juarez, Mariana Patlán, Araceli Páez, Felipe Massó, Luis M. Amezcua-Guerra   +5 more
doaj   +1 more source

Heat Stress Promotes Fibroblast‐Derived WNT5A Secretion Through m6A Modification to Activate Melanogenesis

Advanced Science, EarlyView.
Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan, Yaqing Wen, Yushan Zhang, Lan Zhang, Jianjian Zhu, Zhen Tang, Ling Jiang, Chuhan Fu, Shu Zhou, Keyi Zhang, Jiangfeng Huang, Li Lei, Jing Chen, Qinghai Zeng   +13 more
wiley   +1 more source

Structure and function of vimentin in the generation and secretion of extracellular vimentin in response to inflammation

Cell Communication and Signaling
Abstract The canonical functions of vimentin in cell mechanics and migration have been recently expanded by the discovery of new roles for extracellular vimentin (ECV) in immune responses to infection, injury and cancer. In contrast with the predominantly filamentous form of intracellular vimentin, ECV exists largely as soluble oligomers. The
Zhiyao Yuan, Paul A. Janmey, Christopher A. McCulloch   +2 more
openaire   +3 more sources

Analysis of vimentin distribution in analyzed cells.

, 2014
A) Vimentin was detected by anti-vimentin at the cell surface of HT22 cells transfected with siRNA for 48 h at 37°C by FACS analysis. B) Confocal microscopy of vimentin in HT22 cells transfected for 48 h at 37°C.
Gudrun Ahnert-Hilger (56464), Sandra Hagemann (589283), Anke Schröder (152205), Markus Höltje (589284), Astrid Rohrbeck (236271), Andreas Pich (152212), Ingo Just (308578)   +6 more
core   +1 more source

Renal Tubular Epithelial CRLF1 Interacts With ITGB1 to Accelerate Fibrosis During the Transition From AKI to CKD

Advanced Science, EarlyView.
During renal fibrosis, SMAD3 acts as a transcription factor for CRLF1, promoting its expression and secretion. CRLF1 then binds to ITGB1 via an autocrine mechanism, activating the PI3K‐AKT signaling pathway to mediate renal fibrosis. This accelerates the progression from AKI to CKD, highlighting the therapeutic potential of targeting CRLF1 for ...
Chunjie Wang, Yan Zhang, Fang Bai, Shankui Qian, Feng Feng, Fangyi Lu, Jiahui Fan, Kuipeng Yu, Xiangdong Yang   +8 more
wiley   +1 more source

DYNAMICS OF INTERMEDIATE FILAMENT PROTEIN EXPRESSION IN THE BUFFALO UTERUS DURING THE FOLLICULAR AND LUTEAL PHASE OF THE ESTROUS CYCLE [PDF]

Exploratory Animal and Medical Research
Laminin and vimentin are two intermediate filaments that play a pivotal role in uterine cellular proliferation, differentiation, maintaining cellular integrity or stability, receptivity, and the implantation process.
Sagarika Dehury
doaj   +1 more source

Tumor‐Derived Exosomal circAP2B1 Induces M2 Macrophage Polarization by Enhancing Mitochondrial Homeostasis to Promote Esophageal Squamous Cell Carcinoma Progression

Advanced Science, EarlyView.
ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang, Gang Feng, Youyu Wang, Ruihao Liang, Haixia Pan, Kai Lei   +5 more
wiley   +1 more source