Results 111 to 120 of about 142,715 (302)

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

Decreased vimentin in kidneys after cell treatment. [PDF]

, 2015
Vimentin expression, consistent with epithelial to mesenchymal transition, has been documented in PKD and was found by immunohistochemistry (red) in the control (no cell) group in cyst lining cells.
Jesus H. Dominguez (764672), K. J. Kelly (764669), Ling Han (155543), Jizhong Zhang (764670), Malgorzata Kamocka (764671), Caroline Miller (286856), Vincent H. Gattone II (286857)   +6 more
core   +1 more source

Type-III interferons and rheumatoid arthritis: Correlation between interferon lambda 1 (interleukin 29) and antimutated citrullinated vimentin antibody levels

Autoimmunity, 2017
Aim: To assess serum type III or lambda (λ) interferons (IFN) levels and its clinical and laboratory associations in rheumatoid arthritis (RA). Methods: A cross-sectional study including 43 patients with RA (86% females; age 45.3 ± 10.3 years) and 43 ...
Diana Castillo-Martínez, Maribel Juarez, Mariana Patlán, Araceli Páez, Felipe Massó, Luis M. Amezcua-Guerra   +5 more
doaj   +1 more source

BcII RFLP for the human vimentin gene

Nucleic Acids Research, 1988
A 1.1 kb cDNA clone (hp4F1) encoding the human vimentin gene was identified in a human library by screening with 4F1, a hamster vimentin cDNA. BcII (TGATCA) recognizes a two allele polymorphism: bands A1 at 8.1 kb, and A2 at 3.6 kb. The allele frequency was determined in 47 unrelated Caucasian individuals. The RFLP was mapped to chromosome 10pter-10q23
MARCUS, EM, SMITH, BA, TELENIUS, H, LANDSVATER, RM, BUYS, CHCM, FERRARI, S, PONDER, BAJ, MATHEW, CGP   +7 more
openaire   +4 more sources

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Vimentin and tumor diagnosis

Chinese Journal of Cancer Research, 1991
Vimentin was isolated and purified from the pig eye lens by homogenization, ultracentrifugation, extraction in urea buffer and preparative eletrophoresis. It was identified with SDS-PAGE and rabbit anti-vimentin was raised against the purified vimentin.
Zhang Nong, Zhang Yuee, Chen Zhongnian, Zhang Xiurong, Li Maoshen   +4 more
openaire   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Effects of TBI on vimentin mRNA and protein levels. [PDF]

, 2015
A) Vimentin mRNA levels. B) Analysis of correlation between brain edema and vimentin mRNA levels. C) Vimentin mRNA levels in animals classified according to neurological score. D) Vimentin protein levels.
Maria-Paz Viveros (5656765), Estefania Acaz-Fonseca (286112), Ana Belen Lopez-Rodriguez (748881), Luis M. Garcia-Segura (339947)   +3 more
core   +1 more source

DYNAMICS OF INTERMEDIATE FILAMENT PROTEIN EXPRESSION IN THE BUFFALO UTERUS DURING THE FOLLICULAR AND LUTEAL PHASE OF THE ESTROUS CYCLE [PDF]

Exploratory Animal and Medical Research
Laminin and vimentin are two intermediate filaments that play a pivotal role in uterine cellular proliferation, differentiation, maintaining cellular integrity or stability, receptivity, and the implantation process.
Sagarika Dehury
doaj   +1 more source

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, EarlyView.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source