Therapeutic efficacy of anti-MMP9 antibody in combination with nab-paclitaxel-based chemotherapy in pre-clinical models of pancreatic cancer [PDF]
, 2019 Matrix metalloproteinase 9 (MMP9) is involved in the proteolysis of extracellular proteins and plays a critical role in pancreatic ductal adenocarcinoma (PDAC) progression, invasion and metastasis.
Awasthi, Niranjan +6 more
core +1 more source
Intercompartmental communication in senescence
FEBS Open Bio, EarlyView.Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz +3 more
wiley +1 more source
Alveolar rhabdomyosarcoma in a dog confirmed using myogenin immunohistochemistry: a case report
Veterinární Medicína, 2016 A large mass from the right forelimb of a five-year-old, male, Maltese dog, was resected surgically and examined histopathologically. Grossly, the 4 × 6 cm mass was well-demarcated and firm.
J.K. Park +6 more
doaj +1 more source
Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial-Mesenchymal Transition: Enhanced Efficacy when Combined with Gemcitabine. [PDF]
, 2019 Most pancreatic cancers are usually diagnosed at an advanced stage when they have already metastasized. Epigallocatechin-3-gallate (EGCG), a major polyphenolic constituent of green tea, has been shown to reduce pancreatic cancer growth, but its effect on
Hackman, Robert M +4 more
core +2 more sources
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Spindle cell lipoma in the gingiva of a dog: a case report
Veterinární Medicína, 2015 Spindle cell lipoma is a benign lipomatous tumour that mainly occurs in the subcutis of the head, neck, and shoulder in elderly men. Oral spindle cell lipoma is extremely rare in all species, and no cases have been reported in veterinary medicine.
H.J. Kim +6 more
doaj +1 more source
Intrinsic structural disorder in cytoskeletal proteins. [PDF]
, 2013 Cytoskeleton, the internal scaffold of the cell, displays an exceptional combination of stability and dynamics. It is composed of three major filamentous networks, microfilaments (actin filaments), intermediate filaments (neurofilaments), and ...
Beata Szabo +4 more
core +1 more source
Advanced Healthcare Materials, EarlyView.This work introduces photo‐crosslinkable tyraminated poly(vinyl alcohol)‐gelatin (PVA‐GT) hydrogels as tunable injectable platforms for tissue engineering and growth factor delivery applications. This schematic illustrates the two developed hydrogel formulations and the experimental workflow used to evaluate their physico‐chemical properties in vitro ...
Alessia Longoni +15 more
wiley +1 more source
MOMAST® Downregulates AQP3 Expression and Function in Human Colon Cells
AntioxidantsThe water channel AQP3 is an aquaglyceroporin expressed in villus epithelial cells, and it plays a role in water transport across human colonic surface cells. Beyond water, AQP3 can mediate glycerol and H2O2 transport. Abnormal expression and function of
Ines Angelini +7 more
doaj +1 more source
Diagnostic approach to malignant fibrous histiocytomas of soft tissue in dogs: a case report
Veterinární Medicína, 2013 Malignant fibrous histiocytomas (MFHs), newly named as 'undifferentiated pleomorphic sarcomas' in 2002 by the World Health Organization, generally show an ambiguous origin.
J.S. Ko +5 more
doaj +1 more source