Results 71 to 80 of about 184,324 (306)

Endothelin-1 Drives Epithelial-Mesenchymal Transition In Hypertensive Nephroangiosclerosis [PDF]

, 2016
BACKGROUND: Tubulointerstitial fibrosis, the final outcome of most kidney diseases, involves activation of epithelial mesenchymal transition (EMT). Endothelin‐1 (ET‐1) activates EMT in cancer cells, but it is not known whether it drives EMT in the kidney.
Belloni, Anna S, Buccella, Valentina, CALO', LORENZO, Caroccia, Brasilina, Gioco, Francesca, Guerzoni, Eugenia, GUIDOLIN, DIEGO, Montini, Barbara, Pagnin, Elisa, Petrelli, Lucia, Piazza, Maria, Ravarotto, Verdiana, ROSSI, GIANPAOLO, SECCIA, TERESA MARIA   +13 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Quantitative study of vimentin gene methylation in stool samples for colorectal cancer screening

Journal of Advanced Pharmaceutical Technology & Research, 2019
Due to importance of screening for colorectal cancer the present study was conducted and aimed at investigating the quantitative methylation of vimentin gene in stool, tumor tissue, and healthy tissue of patients with colorectal cancer (CRC) in ...
Behfar Pakbaz, Raheleh Jabinin, Narjes Soltani, Hossein Ayatollahi, Mohammad Reza Farzanehfar   +4 more
doaj   +1 more source

Control of erythroid differentiation: asynchronous expression of the anion transporter and the peripheral components of the membrane skeleton in AEV- and S13-transformed cells [PDF]

, 1986
Chicken erythroblasts transformed with avian erythroblastosis virus or S13 virus provide suitable model systems with which to analyze the maturation of immature erythroblasts into erythrocytes.
Boyer, Brigitte, Lazarides, Elias, Vogt, Peter K., Woods, Catherine M.   +3 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages

Journal of Innate Immunity, 2019
Pathogenic microorganisms are sensed by the inflammasome, resulting in the release of the pro-immune and proinflammatory cytokine interleukin-1β (IL-1β).
Chih-Ming Tsai, Angelica M. Riestra, Syed Raza Ali, Jerry J. Fong, Janet Z. Liu, Gillian Hughes, Ajit Varki, Victor Nizet   +7 more
doaj   +1 more source

Analysis of epithelial–mesenchymal transition markers in psoriatic epidermal keratinocytes [PDF]

Open Biology, 2015
Psoriasis is similar to endpoints of epithelial–mesenchymal transition (EMT), a process of epithelial cells transformed into fibroblast-like cells. The molecular epithelial and mesenchymal markers were analysed in psoriatic keratinocytes.
Xiao-Yong Man, Xi-Bei Chen, Wei Li, Lilla Landeck, Ting-Ting Dou, Jia-qi Chen, Jiong Zhou, Sui-Qing Cai, Min Zheng   +8 more
doaj   +1 more source

Impact of chronic exposure to bevacizumab on EpCAM-based detection of circulating tumor cells [PDF]

, 2015
BACKGROUND: Circulating tumor cells (CTCs) are often undetected through the immunomagnetic epithelial cell adhesion molecule (EpCAM)-based CellSearch(®) System in breast and colorectal cancer (CRC) patients treated with bevacizumab (BEV), where low ...
GAZZANIGA, PAOLA, GRADILONE, Angela, LOTTI, Lavinia Vittoria, MASSIMI, ISABELLA, NICOLAZZO , CHIARA, PULCINELLI, FABIO MARIA, RAIMONDI, CRISTINA, Vespa, Simone   +7 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Subcellular Localization of Sprouty2 in Human Glioma Cells

Frontiers in Molecular Neuroscience, 2019
Sprouty proteins act ubiquitously as signaling integrators and inhibitors of receptor tyrosine kinase (RTK) activated pathways. Among the four Sprouty isoforms, Sprouty2 is a key regulator of growth factor signaling in several neurological disorders ...
Barbara Hausott, Jong-Whi Park, Taras Valovka, Martin Offterdinger, Michael W. Hess, Stephan Geley, Lars Klimaschewski   +6 more
doaj   +1 more source