Results 141 to 150 of about 53,171 (233)

Characterization of a novel R98Q mutation that confers resistance to sulfentrazone in common ragweed (Ambrosia artemisiifolia) populations from Michigan

Pest Management Science, EarlyView.
Field‐collected Ambrosia artemisiifolia populations from Michigan, USA, soybean fields exhibited strong resistance to the protoporphyrinogen IX oxidase (PPO)‐inhibiting herbicide sulfentrazone and reduced sensitivity to fomesafen. Target‐site analysis identified a novel Arg‐98‐Gln (R98Q) substitution in PPO2, co‐occurring with the previously reported ...
Sara Álvarez‐Rodríguez, Michael Ozolins, Aimone Porri, Jens Lerchl, Eric Patterson   +4 more
wiley   +1 more source

Circumventing the Synthesizability Problem in Generative Molecular Design. [PDF]

J Chem Inf Model
Weller JA, Li J, Jiang Y, Rohs R.
europepmc   +1 more source

Dehydrocostus Lactone Suppresses Hepatocellular Carcinoma by Inhibiting Protein Tyrosine Kinase‐7 Mediated β‐Catenin Signaling

Phytotherapy Research, EarlyView.
Schematic summary of the experimentally supported mechanism of DHL in hepatocellular carcinoma. Dehydrocostus lactone (DHL), a sesquiterpene lactone derived from Aucklandia lappa, directly engages protein tyrosine kinase 7 (PTK7), as supported by molecular docking, CETSA, and DARTS assays.
Xiwen Fan, Junhui Li, Yu Qiao, Yuwen Zhong, Xuecheng Ge, Yaoshuai Zhang, Zishu Wang, Feng Qian, Weixin Ren   +8 more
wiley   +1 more source

Draft genome sequences of three <i>Bacillus</i> spp. from the University of the Philippines Culture Collection. [PDF]

Microbiol Resour Announc
Javier KCL, Gloria PCT, Siringan MAT, Argayosa VB.   +3 more
europepmc   +1 more source

Betulinic Acid Enema Alleviates Colitis by Targeting Vitamin D Receptor to Protect the Intestinal Mucosal Barrier and Modulate Mucosa‐Associated Microbiota

Phytotherapy Research, EarlyView.
ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with limited effectiveness and safety of current drug therapies. Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid present in traditional Chinese medicines used clinically as retention enemas for UC, but its direct effects and mechanisms remain unclear ...
Lina Dong, Yuanxia Gao, Qian Li, Guangxin Chen, Dong Yang, Liping Zhao, Xiaojing Liu, Shumei Lin   +7 more
wiley   +1 more source

DDA: a traceable multi-agent framework for automated structure-based drug design. [PDF]

Front Chem
Yu Y, Tian S, Wang G, Li Y.
europepmc   +1 more source

Transcriptome Inference and Systematic Approaches to Investigate TCM Compounds With Beneficial Metabolic Effects

Phytotherapy Research, EarlyView.
ABSTRACT Obesity is a major risk factor for type 2 diabetes. Some traditional Chinese medicine (TCM) compounds can improve obesity by increasing energy consumption. This study aimed to identify and verify TCM compounds that promote adipose thermogenesis to alleviate obesity via transcriptomic analysis, molecular docking, network pharmacology, and ...
Jing Li, Yang‐Chi‐Dung Lin, Hsi‐Yuan Huang, Jihang Chen, Huali Zuo, Yun Tang, Hsien‐Da Huang   +6 more
wiley   +1 more source

A new genus of Gnorimoschemini (Lepidoptera, Gelechiidae, Gelechiinae) from the Atacama and Sechura deserts. [PDF]

Zookeys
Ampuero-Vega J, Campos-Soto R, Vargas HA.   +2 more
europepmc   +1 more source

Baicalin Induces Ferroptosis in Breast Cancer Through a Novel STAT3/HO‐1/GPX4 Regulatory Axis

Phytotherapy Research, EarlyView.
BA inhibits STAT3 phosphorylation and activation in BC cells, accompanied by decreased expression of HO‐1 and GPX4. Reduced GPX4 activity impairs lipid peroxide clearance, promoting ROS accumulation and lipid peroxidation, which ultimately triggers ferroptosis and inhibits cell proliferation.
Tingting Guo, Fansu Meng, Detang Li, Maciej Mazur, Alicia Marcelina Díaz García, Mulazim Hussain Asim, Zhong Chen, Yiqi Chen, Yixuan Lin, Zhenjiang Yang, Panpan Wang, Yu Cai   +11 more
wiley   +1 more source

PockLigGPT: Pocket-Sequence-Conditioned Molecular Generation with GPTs and RL. [PDF]

J Chem Inf Model
Varas Pardo P, Marcos-Ayuso G, Ulzurrun E, Ríos Insua D, Campillo NE.   +4 more
europepmc   +1 more source