Results 111 to 120 of about 9,166 (164)

Vinorelbine: A novel vinca alkaloid

American Journal of Health-System Pharmacy, 1995
The chemistry, pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage and administration of vinorelbine are reviewed. Vinorelbine is a semisynthetic vinca alkaloid with a broader spectrum of antitumor activity in vitro than naturally occurring vinca alkaloids have.
C, Toso, C, Lindley
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Structural modifications of the vinca alkaloids

Cancer Treatment Reviews, 1987
The vinca alkaloids were discovered independently in two separate laboratories by a combinat ion of serendipity and what we have called rational broad spectrum tumor screening. In the first case, R. L. Noble and his colleagues in the Collip Labora tory at the University of Western Ontar io were examining extracts ofCatharanthus roseus G.
I S, Johnson, G J, Cullinan, G B, Boder, C B, Grindey, B C, Laguzza   +4 more
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Clincal pharmacokinetics of vinca alkaloids

Journal of Ethnopharmacology, 1988
Vinca alkaloids (VA) represent a family of closely related molecules, which includes vincristine (VCR), vinblastine (VLB), vindesine (VDS) and navelbine (NVB), a new synthetic VA presently in phase II clinical trial. Development of sensitive and specific analytical tools (polyclonal and monoclonal antibodies) enabled us to investigate the kinetic ...
R, Rahmani, R, Samak, P, Bore, J P, Cano
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Alkaloids of Vinca major

Chemistry of Natural Compounds, 1977
1. From the epigeal part ofVinca major have been isolated the known bases akuammicine, vincamajine, vincamajoridine, and ervine, and the new alkaloid majorinine with the composition C22H24N2O4, mp 195–196°C.
L. I. Il'yashenko, V. M. Malikov, M. R. Yagudaev, S. Yu. Yunusov   +3 more
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Vinca alkaloids

2005
Abstract The periwinkle plant (Cantharantus roseus; Vinca rosea L.), originally indigenous to Madagascar but now cultivated all over the world, has a long and colourful history of medicinal uses for the treatment of such widely dissimilar conditions as haemorrhage, scurvy, toothache, wound healing, and diabetes.
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Vindesine: A New Vinca Alkaloid

1980
Vindesine (VDS) is an analogue of the vinca alkaloids. Its spectrum of antitumoral activity is similar to that of vincristine (VCR), but with milder experimental neurotoxicity, and it inhibits the polymerization of tubulin. Its terminal half-life is 24 h and its plasma clearance is intermediate between those of vinblastine (VLB) and VCR.
M, Bayssas, J, Gouveia, F, de Vassal, J L, Misset, L, Schwarzenberg, P, Ribaud, M, Musset, C, Jasmin, M, Hayat, G, Mathé   +9 more
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The Vinca Alkaloids

Journal of Pediatric Oncology Nursing, 1995
A S, O'Marcaigh, D L, Betcher
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Vinca Alkaloids and Platelet Function

Annals of Internal Medicine, 1984
Excerpt To the editor: The recent article by Ahn and associates (1) reported the use of slow infusions of vinca alkaloids in vivo to load autologous platelets for the treatment of idiopathic thromb...
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Indole Alkaloids from Vinca sardoa, a New Species of Vinca

HETEROCYCLES, 1990
Four natural N-methylindolines have been isolated from the roots of Vinca sardoa (Stearn) Pignati. They are ent-N(1)-methyl-14,15-didehydroaspidospermidine (7),N(1)-methyl-14,15-didehydroaspidofractinine (10), N(1)-methylaspidofractinine (11) and N(1)-methyl-14,15-didehydrotuboxenine (13)
S. CRIPPA, B. DANIELI, G. LESMA, G. PALMISANO, D. PASSARELLA, V. VECCHIETTI   +5 more
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Synthesis and SAR of vinca alkaloid analogues

Bioorganic & Medicinal Chemistry Letters, 2009
Versatile intermediates 12'-iodovinblastine, 12'-iodovincristine and 11'-iodovinorelbine were utilized as substrates for transition metal based chemistry which led to the preparation of novel analogues of the vinca alkaloids. The synthesis of key iodo intermediates, their transformation into final products, and the SAR based upon HeLa and MCF-7 cell ...
Matthew E, Voss, Jeffery M, Ralph, Dejian, Xie, David D, Manning, Xinchao, Chen, Anthony J, Frank, Andrew J, Leyhane, Lei, Liu, Jason M, Stevens, Cheryl, Budde, Matthew D, Surman, Thomas, Friedrich, Denise, Peace, Ian L, Scott, Mark, Wolf, Randall, Johnson   +15 more
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