Results 101 to 110 of about 16,117 (210)

A phase I clinical and pharmacological study evaluating vinflunine in combination with doxorubicin as first line treatment in metastatic breast cancer [PDF]

, 2018
Vinfunine (VFL) is a novel bifluorinated tubulin-targeted agent of the vinca alkaloids class active in advanced stage breast cancer. We conducted a phase I study combining VFL with doxorubicin (DXR) to define the recommended dose (RD), safety ...
Bauer, J., Baurain, J.-F, Bostnavaron, M., Durando, X., Humblet, Y., Machiels, J.-P, Mazzeo, F., Meheust, N., Monnoyer-Favrel, S., Zaman, K.   +9 more
core  

A novel approach to the clinical diagnosis and treatment of canine histiocytic sarcoma [PDF]

This work provides a review of canine histiocytic sarcoma (HS) including background immunology, diagnosis, treatment, and prognosis. Given the poor prognosis of HS compared to other soft tissue sarcomas in dogs, the research performed focuses on ...
Menard, Kimberly
core   +1 more source

First global Report of Alkaloids Tubotaiwine and Vinervine in Vinca herbacea: Potential Pharmacological Applications

Basic & Clinical Cancer Research
Vinca herbacea Waldst. & Kit., a perennial species of the Apocynaceae family, is distributed across temperate regions of Asia and Europe but occurs only in limited areas of northern Iran, particularly along the Alborz Mountains.
Mohammad Kordkatouli, Ali Varasteh Moradi, Mohammad Amin Javidi, Aryan Sateei, Audrius Dulskas, Daiva Luniene   +5 more
doaj  

Gender difference in motor impairments induced by chronic administration of vinblastine [PDF]

, 2014
Objective(s): Neurotoxicity of anticancer drugs complicates treatment of cancer patients. Vinblastine (VBL) is reported to induce motor and cognitive impairments in patients receiving chronic low-dose regimen.
Asadi-Shekaari, Majid, Kermani, Moein, Larizadeh, Mohammad Hassan, Moazzami, Kasra, Nazeri, Masoud, Parsania, Shahrnaz, Razavinasab, Moazamehosadat, Shabani, Mohammad   +7 more
core   +1 more source

Beyond the Paclitaxel and Vinca Alkaloids: Next Generation of Plant-Derived Microtubule-Targeting Agents with Potential Anticancer Activity. [PDF]

Cancers (Basel), 2020
Zhang D, Kanakkanthara A.
europepmc   +1 more source

Catharanthus roseus intoxication mimicking acute cholangitis

BMC Complementary Medicine and Therapies
Background Catharanthus roseus, a Madagascar native flowering plant, is known for its glossy leaves and vibrant flowers, and its medicinal significance due to its alkaloid compounds.
Yoen Young Chuah, Yeong Yeh Lee, Chu-Kuang Chou, Li-Jen Chang   +3 more
doaj   +1 more source

Restoration of Taxol Sensitivity of Multidrug-Resistant Cells by the Cyclosporine SDZ PSC 833 and the Cyclopeptolide SDZ 280-446 [PDF]

, 2017
Background: Taxol, a promising agent for the treatment of cancer, has entered phase II clinical trials. Nevertheless, it belongs to the class of compounds that show impaired retention in multidrug-resistant cells expressing P-glycoprotein (Pgp), a drug ...
Jachez, Bénédicte, Loor, Francis, Nordmann, Rene   +2 more
core  

Chemical composition and antifungal potential of Vinca rosea leaf essential oil and extracts from Northern India

Cogent Food & Agriculture
Advancing understanding of the diverse properties of essential oils has spurred a significant increase in both their production and application. The current research aimed to study the chemical, physical, and antifungal characteristics of Vinca rosea ...
Parul Sharma, Ramandeep Kaur, Urvashi Bhardwaj, Jaspal Kaur   +3 more
doaj   +1 more source

Cytotoxic drug sensitivity of Epstein-Barr virus transformed lymphoblastoid B-cells. [PDF]

, 2006
BACKGROUND: Epstein-Barr virus (EBV) is the causative agent of immunosuppression associated lymphoproliferations such as post-transplant lymphoproliferative disorder (PTLD), AIDS related immunoblastic lymphomas (ARL) and immunoblastic lymphomas in X ...
Eksborg, S., Flaberg, E., Jernberg, A. G., Markasz, L., Oláh, Éva, Stuber, Gy.   +5 more
core  

The endophytic fungus Cosmosporella sp. VM-42 from Vinca minor is a source of bioactive compounds with potent activity against drug-resistant bacteria

Current Research in Microbial Sciences
Medicinal plants serve as valuable resources for the isolation of endophytic fungi. Vinca minor is a well-known producer of important vinca alkaloids and emerges as a promising source of endophytic fungi with antibacterial potential and biosynthetic ...
Ting He, Xiao Li, Rosario del Carmen Flores-Vallejo, Ana-Maria Radu, Jan Maarten van Dijl, Kristina Haslinger   +5 more
doaj   +1 more source