Results 121 to 130 of about 9,166 (164)
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2000
Abstract Vincristine (VCR) and vinblastine (VBL), derivatives of the periwinkle plant (Vinca rosea), are important chemotherapeutic agents with similar neurotoxic actions. VCR, the subject here, is far more widely used than VBL and has Iqbal Z, Ochs S (1980) Uptake of Vinca alkaloids into mammalian nerve and its subcellular components.
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Abstract Vincristine (VCR) and vinblastine (VBL), derivatives of the periwinkle plant (Vinca rosea), are important chemotherapeutic agents with similar neurotoxic actions. VCR, the subject here, is far more widely used than VBL and has Iqbal Z, Ochs S (1980) Uptake of Vinca alkaloids into mammalian nerve and its subcellular components.
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Radioimmunoassays for the vinca alkaloids, vinblastine and vincristine
Analytical Biochemistry, 1979Abstract Radioimmunoassays for the chemotherapeutic alkaloids, vinblastine (VLB) and vincristine (VCR) were developed that could determine less than 1 pmol of each compound in the homologous hapten-antibody reaction. The anti-VCR serum bound VCR 200 times more effectively than VLB, demonstrating a high specificity in spite of the structural ...
J J, Langone +2 more
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Plant Alkaloids: The Vinca Alkaloids
1989Although a large number of compounds from a wide variety of plants have been tested for antitumor activity, none has played a more vital role in cancer chemotherapy than the vinca alkaloids. These compounds are present in minute quantities in the plant Catharanthus roseus G. Don (Vinca rosea Linn.), commonly called the periwinkle.
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Gan to kagaku ryoho. Cancer & chemotherapy, 2008
Vinca alkaloids inhibit microtubule formation by binding to tubulin. There are four clinically available vinca alkaloids including vincristine, vinblastine, vindesine, and vinorelbine. P-glycoprotein(P-gp)is the one of the efflux adenosine triphosphate(ATP)-binding cassette family transporters and is the encoded product of MDR1 gene.
Nagio, Takigawa, Mitsune, Tanimoto
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Vinca alkaloids inhibit microtubule formation by binding to tubulin. There are four clinically available vinca alkaloids including vincristine, vinblastine, vindesine, and vinorelbine. P-glycoprotein(P-gp)is the one of the efflux adenosine triphosphate(ATP)-binding cassette family transporters and is the encoded product of MDR1 gene.
Nagio, Takigawa, Mitsune, Tanimoto
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New Anticancer Vinca Alkaloids in the Last Decade - A Mini-Review
Current Organic Chemistry, 2021Szabolcs Mayer +2 more
exaly
Vinca Alkaloids and Colchicine
1975The vinca alkaloids and the colchicine derivatives, although of widely disparate chemical structure, may be considered to constitute a single class of agents in view of the many similarities in their biochemical and biological actions, most notably in their ability to produce metaphase arrest.
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