Results 141 to 150 of about 83,539 (199)
Is lithium able to reverse neurological damage induced by vinca alkaloids?
Journal of Neural Transmission, 1999 Lithium (Li) actively antagonises the inhibiting action of vinca alkaloids on human leukocyte chemotaxis; it proved to be related to the activation of microtubular system, possibly mediated by its inhibiting effect on cyclic AMP.
Ferdinando Sartucci +2 more
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The incidence of extravasation of vinca alkaloids supplied in syringes or mini-bags.
Journal of Oncology Pharmacy Practice, 2006 Study objective: The aim of this retrospective study was to determine the incidence of vinca alkaloid extravasation following administration via syringes or mini-bags. Methods: An electronic survey was sent to pharmacy departments at hospitals throughout
Peter J. Gilbar
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Reduction of Toxicity of a Vinca Alkaloid by an Anti-Vinca Alkaloid Antibody
Cancer Investigation, 1995Inadvertent oncolytic overdoses occur rarely, but can have serious consequences. We have investigated the possibility of using an antibody, 27.8.1A, reactive with vinca alkaloids, as a means of reducing the toxicity associated with overdose situations.
M C, Gutowski +3 more
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1975
The vinca alkaloids are antineoplastic indole derivatives (Fig. 1) that are isolated from the leaves of the periwinkle plant, Vinca rosea L., or more correctly, Catharanthus roseus G. Don. This plant is of Madagascan origin, although its distribution is now pantropical (Stearn, 1975).
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The vinca alkaloids are antineoplastic indole derivatives (Fig. 1) that are isolated from the leaves of the periwinkle plant, Vinca rosea L., or more correctly, Catharanthus roseus G. Don. This plant is of Madagascan origin, although its distribution is now pantropical (Stearn, 1975).
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2010
The periwinkle plant, Cantharanthus roseus G. Don (Vinca rosea Linn.) is endemic to the island of Madagascar, and has long been ascribed a wide assortment of medicinal properties ranging from the treatment of diabetes to wound healing. Of the over fifty alkaloids present in minute quantities within the plant, only two (vincristine and vinblastine) have
Nicole Coufal, Lauge Farnaes
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The periwinkle plant, Cantharanthus roseus G. Don (Vinca rosea Linn.) is endemic to the island of Madagascar, and has long been ascribed a wide assortment of medicinal properties ranging from the treatment of diabetes to wound healing. Of the over fifty alkaloids present in minute quantities within the plant, only two (vincristine and vinblastine) have
Nicole Coufal, Lauge Farnaes
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Clincal pharmacokinetics of vinca alkaloids
Journal of Ethnopharmacology, 1988Vinca alkaloids (VA) represent a family of closely related molecules, which includes vincristine (VCR), vinblastine (VLB), vindesine (VDS) and navelbine (NVB), a new synthetic VA presently in phase II clinical trial. Development of sensitive and specific analytical tools (polyclonal and monoclonal antibodies) enabled us to investigate the kinetic ...
R, Rahmani, R, Samak, P, Bore, J P, Cano
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2005
Abstract The periwinkle plant (Cantharantus roseus; Vinca rosea L.), originally indigenous to Madagascar but now cultivated all over the world, has a long and colourful history of medicinal uses for the treatment of such widely dissimilar conditions as haemorrhage, scurvy, toothache, wound healing, and diabetes.
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Abstract The periwinkle plant (Cantharantus roseus; Vinca rosea L.), originally indigenous to Madagascar but now cultivated all over the world, has a long and colourful history of medicinal uses for the treatment of such widely dissimilar conditions as haemorrhage, scurvy, toothache, wound healing, and diabetes.
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Vinorelbine: A novel vinca alkaloid
American Journal of Health-System Pharmacy, 1995The chemistry, pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage and administration of vinorelbine are reviewed. Vinorelbine is a semisynthetic vinca alkaloid with a broader spectrum of antitumor activity in vitro than naturally occurring vinca alkaloids have.
C, Toso, C, Lindley
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Structural modifications of the vinca alkaloids
Cancer Treatment Reviews, 1987The vinca alkaloids were discovered independently in two separate laboratories by a combinat ion of serendipity and what we have called rational broad spectrum tumor screening. In the first case, R. L. Noble and his colleagues in the Collip Labora tory at the University of Western Ontar io were examining extracts ofCatharanthus roseus G.
I S, Johnson +4 more
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