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Vinca Alkaloids and Colchicine
1975The vinca alkaloids and the colchicine derivatives, although of widely disparate chemical structure, may be considered to constitute a single class of agents in view of the many similarities in their biochemical and biological actions, most notably in their ability to produce metaphase arrest.
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Gan to kagaku ryoho. Cancer & chemotherapy, 2008
Vinca alkaloids inhibit microtubule formation by binding to tubulin. There are four clinically available vinca alkaloids including vincristine, vinblastine, vindesine, and vinorelbine. P-glycoprotein(P-gp)is the one of the efflux adenosine triphosphate(ATP)-binding cassette family transporters and is the encoded product of MDR1 gene.
Nagio, Takigawa, Mitsune, Tanimoto
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Vinca alkaloids inhibit microtubule formation by binding to tubulin. There are four clinically available vinca alkaloids including vincristine, vinblastine, vindesine, and vinorelbine. P-glycoprotein(P-gp)is the one of the efflux adenosine triphosphate(ATP)-binding cassette family transporters and is the encoded product of MDR1 gene.
Nagio, Takigawa, Mitsune, Tanimoto
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New Anticancer Vinca Alkaloids in the Last Decade - A Mini-Review
Current Organic Chemistry, 2021Szabolcs Mayer +2 more
exaly
Cancer chemotherapy and biological response modifiers, 1990
G, Schwartsmann, R A, Bender
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G, Schwartsmann, R A, Bender
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Preclinical and Clinical Pharmacology of Vinca Alkaloids
Drugs, 2012Xiao-Jian Zhou, Roger Rahmani, R Rahmani
exaly