Results 161 to 170 of about 16,117 (210)
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Reduction of Toxicity of a Vinca Alkaloid by an Anti-Vinca Alkaloid Antibody
Cancer Investigation, 1995Inadvertent oncolytic overdoses occur rarely, but can have serious consequences. We have investigated the possibility of using an antibody, 27.8.1A, reactive with vinca alkaloids, as a means of reducing the toxicity associated with overdose situations.
M C, Gutowski +3 more
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Chemistry of Natural Compounds, 1977
1. From the epigeal part ofVinca major have been isolated the known bases akuammicine, vincamajine, vincamajoridine, and ervine, and the new alkaloid majorinine with the composition C22H24N2O4, mp 195–196°C.
L. I. Il'yashenko +3 more
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1. From the epigeal part ofVinca major have been isolated the known bases akuammicine, vincamajine, vincamajoridine, and ervine, and the new alkaloid majorinine with the composition C22H24N2O4, mp 195–196°C.
L. I. Il'yashenko +3 more
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Phytochemistry, 1995
Abstract Chemical investigations of the aerial parts of Vinca major have resulted in the isolation of two new alkaloids, 10-methoxyperakine and vincawajine. Another alkaloid, 10-methoxyvinorine, is reported for the first time from this species. The structures were determined using spectroscopic techniques.
null Atta-Ur-Rahman +5 more
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Abstract Chemical investigations of the aerial parts of Vinca major have resulted in the isolation of two new alkaloids, 10-methoxyperakine and vincawajine. Another alkaloid, 10-methoxyvinorine, is reported for the first time from this species. The structures were determined using spectroscopic techniques.
null Atta-Ur-Rahman +5 more
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Vindesine: A New Vinca Alkaloid
1980Vindesine (VDS) is an analogue of the vinca alkaloids. Its spectrum of antitumoral activity is similar to that of vincristine (VCR), but with milder experimental neurotoxicity, and it inhibits the polymerization of tubulin. Its terminal half-life is 24 h and its plasma clearance is intermediate between those of vinblastine (VLB) and VCR.
M, Bayssas +9 more
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Labeling Changes for Vinca Alkaloid Chemotherapies
AJN, American Journal of Nursing, 2021The labeling for vinca alkaloid chemotherapy drugs is being revised to remove instructions for their administration with use of a syringe. This revision is in response to inadvertent intrathecal administration of vinca alkaloids, which is normally fatal.
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2010
The periwinkle plant, Cantharanthus roseus G. Don (Vinca rosea Linn.) is endemic to the island of Madagascar, and has long been ascribed a wide assortment of medicinal properties ranging from the treatment of diabetes to wound healing. Of the over fifty alkaloids present in minute quantities within the plant, only two (vincristine and vinblastine) have
Nicole Coufal, Lauge Farnaes
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The periwinkle plant, Cantharanthus roseus G. Don (Vinca rosea Linn.) is endemic to the island of Madagascar, and has long been ascribed a wide assortment of medicinal properties ranging from the treatment of diabetes to wound healing. Of the over fifty alkaloids present in minute quantities within the plant, only two (vincristine and vinblastine) have
Nicole Coufal, Lauge Farnaes
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Vinca Alkaloids and Platelet Function
Annals of Internal Medicine, 1984Excerpt To the editor: The recent article by Ahn and associates (1) reported the use of slow infusions of vinca alkaloids in vivo to load autologous platelets for the treatment of idiopathic thromb...
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Plant Alkaloids: The Vinca Alkaloids
1989Although a large number of compounds from a wide variety of plants have been tested for antitumor activity, none has played a more vital role in cancer chemotherapy than the vinca alkaloids. These compounds are present in minute quantities in the plant Catharanthus roseus G. Don (Vinca rosea Linn.), commonly called the periwinkle.
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Gan to kagaku ryoho. Cancer & chemotherapy, 2008
Vinca alkaloids inhibit microtubule formation by binding to tubulin. There are four clinically available vinca alkaloids including vincristine, vinblastine, vindesine, and vinorelbine. P-glycoprotein(P-gp)is the one of the efflux adenosine triphosphate(ATP)-binding cassette family transporters and is the encoded product of MDR1 gene.
Nagio, Takigawa, Mitsune, Tanimoto
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Vinca alkaloids inhibit microtubule formation by binding to tubulin. There are four clinically available vinca alkaloids including vincristine, vinblastine, vindesine, and vinorelbine. P-glycoprotein(P-gp)is the one of the efflux adenosine triphosphate(ATP)-binding cassette family transporters and is the encoded product of MDR1 gene.
Nagio, Takigawa, Mitsune, Tanimoto
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